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Modulation of fatty acid binding protein 4 and dietary fatty acid intake as a potential therapeutic target in the management of irritable bowel syndrome

2016/21/N/NZ5/01932

Keywords:

irritable bowel syndrome FABP4 fatty acid binding proteins

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment
  • NZ4_12: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Łodzi, Wydzial Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Paula Mosińska 

Number of co-investigators in the project: 3

Call: PRELUDIUM 11 - announced on 2016-03-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2017-03-08

Project end date (Y-m-d): 2020-03-07

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Bile acids and FXR in functional gastrointestinal disorders.
    Authors:
    Mosińska P, Szczepaniak A, Fichna J.
    Academic press:
    Digestive liver diseases (rok: 2018, tom: 50, strony: 795-803), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.dld.2018.05.016 - link to the publication
  2. Chain length of dietary fatty acids determines gastrointestinal motility and visceromotor function in mice in a fatty acid binding protein 4‑dependent manner
    Authors:
    Paula Mosińska, Adrian Szczepaniak, Tatiana Wojciechowicz, Marek Skrzypski, Krzysztof Nowak, Jakub Fichna
    Academic press:
    European Journal of Nutrition (rok: 2020, tom: 6, strony: 2481-2496), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00394-019-02094-2 - link to the publication
  3. Dietary fatty acid content influences the expression of genes involved in the lipid turnover and inflammation in mouse colon and spleen
    Authors:
    Paula Mosinska, Aleksandra Tarasiuk, Adam Fabisiak, Julia Krajewska, Karolina Niewinna, Adrian Bartoszek, Agata Binienda, Maciej Sałaga, Jakub Fichna
    Academic press:
    Pharmacological Reports (rok: 2019, tom: 71, strony: 899-908), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2019.07.010 - link to the publication
  4. FABP4 blocker attenuates colonic hypermotility and modulates white adipose tissue-derived hormone levels in mouse models mimicking constipation-predominant IBS
    Authors:
    Mosińska P, Jacenik D, Sałaga M, Wasilewski A, Cygankiewicz A, Sibaev A, Mokrowiecka A, Małecka-Panas E, Pintelon I, Storr M, Timmermans JP, Krajewska WM, Fichna J.
    Academic press:
    Neurogastroenterol Motil. (rok: 2017, tom: e13272, strony: 45304), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/nmo.13272. - link to the publication
  5. Triphala: current applications and new perspectives on the treatment of functional gastrointestinal disorders.
    Authors:
    Tarasiuk A, Mosińska P, Fichna .
    Academic press:
    Chinese Medicine (rok: 2018, tom: 18, strony: 45302), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s13020-018-0197-6 - link to the publication
  6. Future Treatment of Constipation-associated Disorders: Role of Relamorelin and Other Ghrelin Receptor Agonists.
    Authors:
    Mosińska P, Zatorski H, Storr M, Fichna J.
    Academic press:
    J Neurogastroenterol Motil. (rok: 2017, tom: 2, strony: 171-179), Wydawca: Korean Society of Neurogastroenterology and Motility
    Status:
    Published
    DOI:
    10.5056/jnm16183. - link to the publication

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