Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Understanding Apicoplast Gyrases

2016/21/B/NZ1/00274

Keywords:

Topoisomerase antibacterials antimalarial malaraia toxoplasmosis DNA topology gyrase

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_4: Structural biology
  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jonathan Heddle 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 776 488 PLN

Project start date (Y-m-d): 2017-02-15

Project end date (Y-m-d): 2021-02-14

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Inhibitory compounds targeting Plasmodium falciparum Gyrase B.
    Authors:
    Pakosz, Z., Lin, T.-Y., Michalczyk, E., Nagano, S., Heddle. J. G.
    Academic press:
    Antimicrobial Agents and Chemotherapy (rok: 2021, tom: 65 (10), strony: e00267-21), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/AAC.00267-21 - link to the publication
  2. A Peptide–Nucleic Acid Replicator Origin for Life.
    Authors:
    Piette, B.M. and Heddle, J.G.
    Academic press:
    Trends in ecology & evolution (rok: 2020, tom: 35 (5), strony: 397-406), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tree.2020.01.001 - link to the publication
  3. Pentapeptide repeat protein QnrB1 requires ATP hydrolysis to rejuvenate poisoned gyrase complexes.
    Authors:
    Mazurek, Ł., Ghilarov, D., Michalczyk, E., Pakosz, Z., Metelev, M., Czyszczoń, W., ... & Heddle, J. G.
    Academic press:
    Nucleic Acids Research (rok: 2021, tom: 49 (3), strony: 1581-1596), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkaa1266 - link to the publication
  4. Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin
    Authors:
    Michalczyk, E., Hommernick, K., Behroz, I., Kulike, M., Pakosz-Stępień, Z., Mazurek, L., Seidel, M., Kunert, M., Sanots, K., von Moeller, H., Loll, B., WEston, J. B., Maiz, A. Heddle, J. G., Süssmuth, R.D., Ghilarov, D.
    Academic press:
    Nature Catalysis (rok: 2023, tom: 6, strony: 52–67), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41929-022-00904-1 - link to the publication
  5. A bacteriophage mimic of the bacterial nucleoid-associated protein Fis.
    Authors:
    Chakraborti, S., Balakrishnan, D., Trotter, A. J., Gittens, W. H., Yang, A. W., Jolma, A., ... & Sharples, G. J.
    Academic press:
    Biochemical Journal (rok: 2020, tom: 477 (7), strony: 1345-1362), Wydawca: Portland Press
    Status:
    Published
    DOI:
    10.1042/BCJ20200146 - link to the publication

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