Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Molecular mechanism of exogenous hormonally active compounds in the biology of human granulosa tumors.

2016/21/B/NZ7/01080

Keywords:

Endocrine disrupting chemicals human granulosa tumors viability anoikis invasion

Descriptors:

  • NZ7_2: Environment and health risks
  • NZ3_1: Cell biology
  • NZ4_6: Endocrinology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Ptak 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 834 900 PLN

Project start date (Y-m-d): 2017-02-09

Project end date (Y-m-d): 2020-08-08

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mikroskop odwrócony z jasnym polem, kontrastem fazowym i fluorescencyjnym wraz z kamerą i oprogramowaniem do analizy obrazu (135 000 PLN)
  2. Zamrażalka niskotemperturowa -86° o pojemości 86l (20 000 PLN)
  3. Inkubator IL 23 DIGITAL. AMB..

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (4)
  1. Disruption of 17β-estradiol secretion by persistent organic pollutants present in human follicular fluid is dependent on the potential of ovarian granulosa tumor cell lines to metabolize estrogen
    Authors:
    Gogola J, Hoffmann M, Nimpsz S, Ptak A
    Academic press:
    Molecular and Cellular Endocrinology (rok: 2020, tom: 1, strony: 503:110698), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mce.2019.110698 - link to the publication
  2. Persistent endocrine-disrupting chemicals found in human follicular fluid stimulate the proliferation of granulosa tumor spheroids via GPR30 and IGF1R but not via the classic estrogen receptors
    Authors:
    Gogola J, Hoffmann M, Ptak A
    Academic press:
    Chemosphere (rok: 2019, tom: 217, strony: 100-110), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.chemosphere.2018.11.018. - link to the publication
  3. Persistent endocrine-disrupting chemicals found in human follicular fluid stimulate IGF1 secretion by adult ovarian granulosa cell tumor spheroids and thereby increase proliferation of non-cancer ovarian granulosa cells
    Authors:
    Gogola J, Hoffmann M, Ptak A
    Academic press:
    Toxicol In Vitro (rok: 2020, tom: 8, strony: 65:104769), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2020.104769 - link to the publication
  4. Mixtures of persistent organic pollutants increase ovarian granulosa tumor cell line migration and spheroid invasion by upregulating MMP2 expression and activity via IGF1R
    Authors:
    Justyna Gogola-Mruk, Marta Hoffmann-Młodzianowska, Kinga Kamińska, Anna Ptak
    Academic press:
    Toxicology (rok: 2021, tom: 452, strony: 152715), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tox.2021.152715 - link to the publication
  1. Persistent endocrine-disrupting chemicals in human follicular fluid stimulate proliferation in granulosa tumor spheroids
    Authors:
    Gogola J, Hoffmann M, Ptak A
    Conference:
    38th International Symposium on Halogenated Persistent Organic Pollutants (POPs) & 10th International PCB Workshop : DIOXIN 2018 (rok: 2018, ), Wydawca: Organohalogen Compounds
    Data:
    konferencja 26-31 sierpień
    Status:
    Published
  2. The mixture of persistent organic pollutants present in human follicular fluid stimulates the estradiol secretion by adult granulosa tumor spheroids via the classic and non-classic estrogen receptors
    Authors:
    Gogola J, Hoffmann M, Nimpsz N, Ptak A
    Conference:
    55th Congress of the European Societies of Toxicology (EUROTOX 2019) (rok: 2019, ), Wydawca: Elsevier
    Data:
    konferencja 8-11 wrzesień
    Status:
    Published
  3. Endocrine-disrupting chemicals present in human follicular fluid disrupt granulosa cell tumors E2 secretion dependent on estrogen metabolism potential
    Authors:
    Gogola J, Hoffmann M, Nimpsz S, Ptak A
    Conference:
    21st European Congress on Gynaecological Oncology (ESGO 2019) (rok: 2019, ), Wydawca: BMJ Journals
    Data:
    konferencja 2-5 listopad
    Status:
    Published
  4. Persistent endocrine-disrupting chemicals found in human follicular fluid stimulate proliferation of granulosa tumor via IGF1R – 3D cell culture model
    Authors:
    Justyna Gogola, Marta Hoffmann and Anna Ptak
    Conference:
    LINZ 2018 - EUSAAT 2018; 21st European Congress on Alternatives to Animal Testing - 18th Annual Congress of EUSAAT (rok: 2018, ), Wydawca: Springer Spektrum
    Data:
    konferencja 23-26 wrzesień
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy