Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Cardioprotective flavonoids: a new regulators of mitochondrial potassium channels?

2016/21/B/NZ1/02769

Keywords:

flavonoids mitochondria potassium channels cytoprotection

Descriptors:

  • NZ1_3: Biophysics
  • NZ1_2: Biochemistry
  • NZ1_11: Other related subjects

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Piotr Bednarczyk 

Number of co-investigators in the project: 6

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 221 100 PLN

Project start date (Y-m-d): 2017-07-03

Project end date (Y-m-d): 2021-07-02

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Rotor wychylny wraz z adapterami na probówki 15 i 50 ml do wirówki EPPENDORF 5408R (7 500 PLN)
  2. System do produkcji wody dejonizowanej (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (11)
  • Articles in post-conference publications (22)
  • Book publications / chapters in book publications (1)
  1. Measurement of Multi Ion Transport through Human Bronchial Epithelial Cell Line Provides an Insight into the Mechanism of Defective Water Transport in Cystic Fibrosis
    Authors:
    Zajac M, Lewenstam A, Bednarczyk P, Dolowy K
    Academic press:
    Membranes (rok: 2020, tom: 10, strony: 43), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes10030043 - link to the publication
  2. Differences in Gating Dynamics of BK Channels in Cellular and Mitochondrial Membranes from Human Glioblastoma Cells Unraveled by Short- and Long-Range Correlations Analysis
    Authors:
    Wawrzkiewicz-Jałowiecka A, Trybek P, Borys P, Dworakowska B, Machura Ł, Bednarczyk P
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 2305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9102305 - link to the publication
  3. Evidence for a mitochondrial ATP-regulated potassium channel in human dermal fibroblasts.
    Authors:
    Bednarczyk P, Kicinska A, Laskowski M, Kulawiak B, Kampa R, Walewska A, Krajewska M, Jarmuszkiewicz W, Szewczyk A
    Academic press:
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (rok: 2018, tom: 1859, strony: 309-318), Wydawca: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
    Status:
    Published
    DOI:
    10.1016/j.bbabio.2018.02.005 - link to the publication
  4. Flavonoid quercetin abolish paxilline inhibition of the mitochondrial BKCa channel
    Authors:
    Rafał Paweł Kampa, Aleksandra Gliździńska, Adam Szewczyk, Piotr Bednarczyk, Sławomir Filipek
    Academic press:
    Mitochondrion (rok: 2022, tom: 65, strony: 23-32), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mito.2022.04.005 - link to the publication
  5. Naringenin as an opener of mitochondrial potassium channels in dermal fibroblasts.
    Authors:
    Kampa RP, Kicinska A, Jarmuszkiewicz W, Pasikowska-Piwko M, Dolegowska B, Debowska R, Szewczyk A, Bednarczyk P.
    Academic press:
    Experimental Dermatology (rok: 2019, tom: 28, strony: 543-550), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/exd.13903 - link to the publication
  6. Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?
    Authors:
    Kicinska A, Jarmuszkiewicz W
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 3060), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25133060 - link to the publication
  7. Cytoprotective effects of the flavonoid quercetin by activating mitochondrial BKCa channels in endothelial cells.
    Authors:
    Kampa RP, Sęk A, Szewczyk A, Bednarczyk P.
    Academic press:
    Biomedicine Pharmacotherapy (rok: 2021, tom: 142, strony: 112039), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2021.112039 - link to the publication
  8. Regulation of the Mitochondrial BKCa Channel by the Citrus Flavonoid Naringenin as a Potential Means of Preventing Cell Damage
    Authors:
    Kicinska A, Kampa RP, Daniluk J, Sek A, Jarmuszkiewicz W, Szewczyk A, Bednarczyk P
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 3010), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25133010 - link to the publication
  9. Functional Expression of TRPV1 Ion Channel in the Canine Peripheral Blood Mononuclear Cells
    Authors:
    Bujak JK, Kosmala D, Majchrzak-Kuligowska K, Bednarczyk P
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 3177), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22063177 - link to the publication
  10. Multidimensional Regulation of Cardiac Mitochondrial Potassium Channels
    Authors:
    Kulawiak B, Bednarczyk P, Szewczyk A
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 1554), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10061554 - link to the publication
  11. Mitochondrial potassium channels - an overview.
    Authors:
    Szewczyk A, Bednarczyk P, Jędraszko J, Kampa RP, Koprowski P, Krajewska M, Kucman S, Kulawiak B, Laskowski M, Rotko D, Sęk A, Walewska A, Żochowska M, Wrzosek A.
    Academic press:
    Postepy biochemii (rok: 2018, tom: 64, strony: 196-212), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2018_132 - link to the publication
  1. Flavonoid-induced changes in oxygen consumption and mitochondrial membrane potential in isolated endothelial mitochondria.
    Authors:
    A.Kicinska, P.Bednarczyk, R.Kampa, A.Szewczyk, W.Jarmuszkiewicz
    Conference:
    3rd Congress of Polish Biosciences BIO2018 Through interdisciplinary approach into new solutions" (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18–21 wrzesnia, 2018 r. Gdańsk
    Status:
    Published
  2. The influence of flavonoids on oxygen consumption and membrane potential of isolated endothelial mitochondria via modulation of mitoBKCa channel activity.
    Authors:
    A.Kicinska, P.Bednarczyk, R.Kampa, A.Szewczyk, W.Jarmuszkiewicz
    Conference:
    20th European Bioenergetics Conference (rok: 2018, ), Wydawca: Elsevier - Biochimica et Biophysica Acta - Bioenergetics
    Data:
    konferencja 25-30 sierpnia, 2018 r. Budapeszt
    Status:
    Published
  3. Localization of the BKCa channel in the inner mitochondria membrane of human bronchial epithelial cell line
    Authors:
    A Sek, R Kampa, T Bauer, P Bednarczyk, A Szewczyk
    Conference:
    The 16th Conference of Asian Society for Mitochondrial Research and Medicine (rok: 2019, ), Wydawca: 16th ASMRM & 19th J-mit in Fukuoka
    Data:
    konferencja 43802
    Status:
    Published
  4. Naringenin as an opener of mitochondrial potassium channels
    Authors:
    P. Bednarczyk, R. P. Kampa, A. Sek, A. Kicinska, W. Jarmuszkiewicz, A. Szewczyk
    Conference:
    44th FEBS CONGRESS (rok: 2019, ), Wydawca: FEBS Open Bio
    Data:
    konferencja 43652
    Status:
    Published
  5. Oxygen consumption and mitochondrial membrane potential in isolated endothelial mitochondria can be modulated by flavonoids.
    Authors:
    A.Kicinska, P.Bednarczyk, R.Kampa, A.Szewczyk, W.Jarmuszkiewicz
    Conference:
    7th Mitochondrion 2018 "Mitochondria in the spotlight" (rok: 2018, ), Wydawca: Faculty of Biotechnology University of Wrocław
    Data:
    konferencja 18-19 października 2018 r. Wrocław
    Status:
    Published
  6. Cardioprotective flavoniods as a natural modulators of mitoBKCa channel.
    Authors:
    Kampa RP, Kicinska A, Kulawiak B, Jarmuszkiewicz W, Szewczyk A, Bednarczyk P
    Conference:
    11th MitoEAGLE Training School - MiPschool 2018. From basics of mitochondrial physiology to cardiovascular health and disease. (rok: 2018, ), Wydawca: Mitochondrial Physiology Society
    Data:
    konferencja 20-24 października 2018 r.
    Status:
    Published
  7. Mitochondrial regulation of mitochondrial potassium channels.
    Authors:
    A.Szewczyk, P.Koprowski, B.Kulawiak, P.Bednarczyk
    Conference:
    20th European Bioenergetics Conference (rok: 2018, ), Wydawca: Elsevier - Biochimica et Biophysica Acta - Bioenergetics
    Data:
    konferencja 25-30 sierpnia, 2018 r. Budapeszt
    Status:
    Published
  8. Identification of potassium channels in the mitochondria of human bronchial epithelial cells.
    Authors:
    A.Sęk, R.Kampa, B.Kulawiak, A.Szewczyk, P.Bednarczyk
    Conference:
    3rd Congress of Polish Biosciences BIO2018 Through interdisciplinary approach into new solutions" (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18–21 wrzesnia, 2018 r. Gdańsk
    Status:
    Published
  9. Czy flawonoidy mogą regulować aktywność mitochondrialnych kanałów potasowych?
    Authors:
    P.Bednarczyk, R.Kampa, A.Sęk, A.Kicinska, B.Kulawiak, W.Jarmuszkiewicz, A.Szewczyk
    Conference:
    XII Ogólnopolska Konferencja "FLAWONOIDY I ICH ZASTOSOWANIE" (rok: 2018, ), Wydawca: Oficyna Wydawnicza Politechniki Rzeszowskiej
    Data:
    konferencja 9-11 maja 2018 r. Łańcut
    Status:
    Published
  10. Naringenin as natural modulator of mitochondrial potassium channels.
    Authors:
    R.Kampa, A.Szewczyk, P.Bednarczyk
    Conference:
    6th Mitochondrion 2017 "Bioenergetics Update" (rok: 2017, ), Wydawca: Department of Bioenergetics, Institute of Molecular Biology and Biotechnology Faculty of Biology, Adam Mickiewicz University, Poznań
    Data:
    konferencja 8 grudnia 2017 r. Poznań
    Status:
    Published
  11. Direct localization of the BKCa channel in the mitochondria of human bronchial epithelial cell line
    Authors:
    A. Sęk, R. P. Kampa, B. Kulawiak, T. Bauer, A. Szewczyk, P. Bednarczyk
    Conference:
    44th FEBS CONGRESS (rok: 2019, ), Wydawca: FEBS Open Bio
    Data:
    konferencja 43652
    Status:
    Published
  12. Regulation of the mitoBKCa channel by cardioprotective flavonoids
    Authors:
    R. Kampa, A. Sęk, A. Kicinska, W. Jarmuszkiewicz, A. Szewczyk, P. Bednarczyk
    Conference:
    44th FEBS CONGRESS (rok: 2019, ), Wydawca: FEBS Open Bio
    Data:
    konferencja 43652
    Status:
    Published
  13. Naringenin-induced mitoBKCa channel-dependent changes in endothelial mitochondria.
    Authors:
    Kicinska A, Bednarczyk P, Kampa RP, Szewczyk A, Jarmuszkiewicz W.
    Conference:
    13th World Congeress on Polyphenols Applications (rok: 2019, ), Wydawca: International Society of Antioxidants
    Data:
    konferencja 43738
    Status:
    Published
  14. Potassium channels as a target of cytoprotective agents.
    Authors:
    P.Bednarczyk
    Conference:
    XXIV Konferencja Szkoleniowa i XX Konferencja Wspólna Sekcji Elektrokardiologii Nieinwazyjnej i Telemedycyny oraz ISHNE (rok: 2018, ), Wydawca: Polskie Towarzystwo Kardiologiczne
    Data:
    konferencja 28 lutego - 3 marca, 2018, Zakopane
    Status:
    Published
  15. Natural compounds as a modulators of mitochondrial large conductance Ca2+-regulated potassium channel (mitoBKCa) activity
    Authors:
    R. P. Kampa, A. Sek, A. Kicinska, W. Jarmuszkiewicz, A. Szewczyk, P. Bednarczyk
    Conference:
    The 16th Conference of Asian Society for Mitochondrial Research and Medicine (rok: 2019, ), Wydawca: 16th ASMRM & 19th J-mit in Fukuoka
    Data:
    konferencja 43802
    Status:
    Published
  16. Cardioprotective flavonoids as a modulators of potassium channels.
    Authors:
    P.Bednarczyk, R.Kampa, A.Sęk, A.Kicińska, B.Kulawiak, W.Jarmuszkiewicz, A.Szewczyk
    Conference:
    7th Mitochondrion 2018 "Mitochondria in the spotlight" (rok: 2018, ), Wydawca: Faculty of Biotechnology University of Wrocław
    Data:
    konferencja 18-19 października 2018 r. Wrocław
    Status:
    Published
  17. A novel potassium channels in the human bronchial epithelial mitochondria.
    Authors:
    A.Sęk, R.Kampa, B.Kulawiak, A.Szewczyk, P.Bednarczyk
    Conference:
    7th Mitochondrion 2018 "Mitochondria in the spotlight" (rok: 2018, ), Wydawca: Faculty of Biotechnology University of Wrocław
    Data:
    konferencja 18-19 października 2018 r. Wrocław
    Status:
    Published
  18. Beneficial Effect of Citrus Flavonoid - Naringenin on Endothelial Cells by Activation of Mitochondrial Potassium Channels
    Authors:
    Kampa RP. Sek, A. Kicinska A. Daniluk J. Jarmuszkiewicz W. Szewczyk A. Bednarczyk P
    Conference:
    64th Annual Meeting of the Biophysical-Society (rok: 2020, ), Wydawca: BIOPHYSICAL JOURNAL
    Data:
    konferencja FEB 15-19, 2020
    Status:
    Published
  19. Regulation of mitochondrial potassium channels by cardioprotective flavonoids.
    Authors:
    R.Kampa, A.Sęk, A.Kicińska, B.Kulawiak, W.Jarmuszkiewicz, A.Szewczyk, P.Bednarczyk
    Conference:
    7th Mitochondrion 2018 "Mitochondria in the spotlight" (rok: 2018, ), Wydawca: Faculty of Biotechnology University of Wrocław
    Data:
    konferencja 18-19 października 2018 r. Wrocław
    Status:
    Published
  20. Mitochondrial regulation of mitochondrial potassium channels.
    Authors:
    A.Szewczyk, P.Koprowski, B.Kulawiak, P.Bednarczyk
    Conference:
    3rd Congress of Polish Biosciences BIO2018 Through interdisciplinary approach into new solutions" (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18–21 wrzesnia, 2018 r. Gdańsk
    Status:
    Published
  21. Cardioprotective flavoniods as natural modulators of mitochondrial potassium channels.
    Authors:
    R.Kampa, A.Sęk, A.Kicińska, B.Kulawiak, W.Jarmuszkiewicz, A.Szewczyk, P.Bednarczyk
    Conference:
    3rd Congress of Polish Biosciences BIO2018 Through interdisciplinary approach into new solutions" (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18–21 wrzesnia, 2018 r. Gdańsk
    Status:
    Published
  22. Modulation of mitochondrial potassium channel activity (mitoBKCa) by flavonoids changes bioenergetic parameters in human endothelial cell mitochondria.
    Authors:
    Kicinska A, Bednarczyk P, Szewczyk A, Jarmuszkiewicz W.
    Conference:
    V Konferencja Naukowo-Dydaktyczna Wydziału Biologii UAM - Wyzwania współczesnych nauk o życiu (rok: 2019, ), Wydawca: Wydział Biologii UAM
    Data:
    konferencja 43563
    Status:
    Published
  1. Patch-Clamp Recording of the Activity of Ion Channels in the Inner Mitochondrial Membrane
    Authors:
    Bednarczyk P, Kampa RP, Gałecka S, Sek A, Walewska A, Koprowski P
    Book:
    Mitochondrial Medicine (rok: 2021, tom: 2276, strony: 235-248), Wydawca: Springer
    Status:
    Published

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