Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Cardioprotective flavonoids: a new regulators of mitochondrial potassium channels?

2016/21/B/NZ1/02769

Keywords:

flavonoids mitochondria potassium channels cytoprotection

Descriptors:

  • NZ1_3: Biophysics
  • NZ1_2: Biochemistry
  • NZ1_11: Other related subjects

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Piotr Bednarczyk 

Number of co-investigators in the project: 6

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 221 100 PLN

Project start date (Y-m-d): 2017-07-03

Project end date (Y-m-d): 2021-07-02

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. System do produkcji wody dejonizowanej (15 000 PLN)
  2. Rotor wychylny wraz z adapterami na probówki 15 i 50 ml do wirówki EPPENDORF 5408R (7 500 PLN)

Information in the final report

  • Publication in academic press/journals (11)
  • Articles in post-conference publications (22)
  • Book publications / chapters in book publications (1)
  1. Regulation of the Mitochondrial BKCa Channel by the Citrus Flavonoid Naringenin as a Potential Means of Preventing Cell Damage
    Authors:
    Kicinska A, Kampa RP, Daniluk J, Sek A, Jarmuszkiewicz W, Szewczyk A, Bednarczyk P
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 3010), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25133010 - link to the publication
  2. Measurement of Multi Ion Transport through Human Bronchial Epithelial Cell Line Provides an Insight into the Mechanism of Defective Water Transport in Cystic Fibrosis
    Authors:
    Zajac M, Lewenstam A, Bednarczyk P, Dolowy K
    Academic press:
    Membranes (rok: 2020, tom: 10, strony: 43), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes10030043 - link to the publication
  3. Cytoprotective effects of the flavonoid quercetin by activating mitochondrial BKCa channels in endothelial cells.
    Authors:
    Kampa RP, Sęk A, Szewczyk A, Bednarczyk P.
    Academic press:
    Biomedicine Pharmacotherapy (rok: 2021, tom: 142, strony: 112039), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2021.112039 - link to the publication
  4. Functional Expression of TRPV1 Ion Channel in the Canine Peripheral Blood Mononuclear Cells
    Authors:
    Bujak JK, Kosmala D, Majchrzak-Kuligowska K, Bednarczyk P
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 3177), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22063177 - link to the publication
  5. Multidimensional Regulation of Cardiac Mitochondrial Potassium Channels
    Authors:
    Kulawiak B, Bednarczyk P, Szewczyk A
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 1554), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10061554 - link to the publication
  6. Differences in Gating Dynamics of BK Channels in Cellular and Mitochondrial Membranes from Human Glioblastoma Cells Unraveled by Short- and Long-Range Correlations Analysis
    Authors:
    Wawrzkiewicz-Jałowiecka A, Trybek P, Borys P, Dworakowska B, Machura Ł, Bednarczyk P
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 2305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9102305 - link to the publication
  7. Evidence for a mitochondrial ATP-regulated potassium channel in human dermal fibroblasts.
    Authors:
    Bednarczyk P, Kicinska A, Laskowski M, Kulawiak B, Kampa R, Walewska A, Krajewska M, Jarmuszkiewicz W, Szewczyk A
    Academic press:
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (rok: 2018, tom: 1859, strony: 309-318), Wydawca: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
    Status:
    Published
    DOI:
    10.1016/j.bbabio.2018.02.005 - link to the publication
  8. Flavonoid quercetin abolish paxilline inhibition of the mitochondrial BKCa channel
    Authors:
    Rafał Paweł Kampa, Aleksandra Gliździńska, Adam Szewczyk, Piotr Bednarczyk, Sławomir Filipek
    Academic press:
    Mitochondrion (rok: 2022, tom: 65, strony: 23-32), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mito.2022.04.005 - link to the publication
  9. Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?
    Authors:
    Kicinska A, Jarmuszkiewicz W
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 3060), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25133060 - link to the publication
  10. Mitochondrial potassium channels - an overview.
    Authors:
    Szewczyk A, Bednarczyk P, Jędraszko J, Kampa RP, Koprowski P, Krajewska M, Kucman S, Kulawiak B, Laskowski M, Rotko D, Sęk A, Walewska A, Żochowska M, Wrzosek A.
    Academic press:
    Postepy biochemii (rok: 2018, tom: 64, strony: 196-212), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2018_132 - link to the publication
  11. Naringenin as an opener of mitochondrial potassium channels in dermal fibroblasts.
    Authors:
    Kampa RP, Kicinska A, Jarmuszkiewicz W, Pasikowska-Piwko M, Dolegowska B, Debowska R, Szewczyk A, Bednarczyk P.
    Academic press:
    Experimental Dermatology (rok: 2019, tom: 28, strony: 543-550), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/exd.13903 - link to the publication
  1. Mitochondrial regulation of mitochondrial potassium channels.
    Authors:
    A.Szewczyk, P.Koprowski, B.Kulawiak, P.Bednarczyk
    Conference:
    20th European Bioenergetics Conference (rok: 2018, ), Wydawca: Elsevier - Biochimica et Biophysica Acta - Bioenergetics
    Data:
    konferencja 25-30 sierpnia, 2018 r. Budapeszt
    Status:
    Published
  2. Natural compounds as a modulators of mitochondrial large conductance Ca2+-regulated potassium channel (mitoBKCa) activity
    Authors:
    R. P. Kampa, A. Sek, A. Kicinska, W. Jarmuszkiewicz, A. Szewczyk, P. Bednarczyk
    Conference:
    The 16th Conference of Asian Society for Mitochondrial Research and Medicine (rok: 2019, ), Wydawca: 16th ASMRM & 19th J-mit in Fukuoka
    Data:
    konferencja 43802
    Status:
    Published
  3. Oxygen consumption and mitochondrial membrane potential in isolated endothelial mitochondria can be modulated by flavonoids.
    Authors:
    A.Kicinska, P.Bednarczyk, R.Kampa, A.Szewczyk, W.Jarmuszkiewicz
    Conference:
    7th Mitochondrion 2018 "Mitochondria in the spotlight" (rok: 2018, ), Wydawca: Faculty of Biotechnology University of Wrocław
    Data:
    konferencja 18-19 października 2018 r. Wrocław
    Status:
    Published
  4. Identification of potassium channels in the mitochondria of human bronchial epithelial cells.
    Authors:
    A.Sęk, R.Kampa, B.Kulawiak, A.Szewczyk, P.Bednarczyk
    Conference:
    3rd Congress of Polish Biosciences BIO2018 Through interdisciplinary approach into new solutions" (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18–21 wrzesnia, 2018 r. Gdańsk
    Status:
    Published
  5. Localization of the BKCa channel in the inner mitochondria membrane of human bronchial epithelial cell line
    Authors:
    A Sek, R Kampa, T Bauer, P Bednarczyk, A Szewczyk
    Conference:
    The 16th Conference of Asian Society for Mitochondrial Research and Medicine (rok: 2019, ), Wydawca: 16th ASMRM & 19th J-mit in Fukuoka
    Data:
    konferencja 43802
    Status:
    Published
  6. Modulation of mitochondrial potassium channel activity (mitoBKCa) by flavonoids changes bioenergetic parameters in human endothelial cell mitochondria.
    Authors:
    Kicinska A, Bednarczyk P, Szewczyk A, Jarmuszkiewicz W.
    Conference:
    V Konferencja Naukowo-Dydaktyczna Wydziału Biologii UAM - Wyzwania współczesnych nauk o życiu (rok: 2019, ), Wydawca: Wydział Biologii UAM
    Data:
    konferencja 43563
    Status:
    Published
  7. Naringenin-induced mitoBKCa channel-dependent changes in endothelial mitochondria.
    Authors:
    Kicinska A, Bednarczyk P, Kampa RP, Szewczyk A, Jarmuszkiewicz W.
    Conference:
    13th World Congeress on Polyphenols Applications (rok: 2019, ), Wydawca: International Society of Antioxidants
    Data:
    konferencja 43738
    Status:
    Published
  8. Regulation of the mitoBKCa channel by cardioprotective flavonoids
    Authors:
    R. Kampa, A. Sęk, A. Kicinska, W. Jarmuszkiewicz, A. Szewczyk, P. Bednarczyk
    Conference:
    44th FEBS CONGRESS (rok: 2019, ), Wydawca: FEBS Open Bio
    Data:
    konferencja 43652
    Status:
    Published
  9. A novel potassium channels in the human bronchial epithelial mitochondria.
    Authors:
    A.Sęk, R.Kampa, B.Kulawiak, A.Szewczyk, P.Bednarczyk
    Conference:
    7th Mitochondrion 2018 "Mitochondria in the spotlight" (rok: 2018, ), Wydawca: Faculty of Biotechnology University of Wrocław
    Data:
    konferencja 18-19 października 2018 r. Wrocław
    Status:
    Published
  10. Cardioprotective flavoniods as a natural modulators of mitoBKCa channel.
    Authors:
    Kampa RP, Kicinska A, Kulawiak B, Jarmuszkiewicz W, Szewczyk A, Bednarczyk P
    Conference:
    11th MitoEAGLE Training School - MiPschool 2018. From basics of mitochondrial physiology to cardiovascular health and disease. (rok: 2018, ), Wydawca: Mitochondrial Physiology Society
    Data:
    konferencja 20-24 października 2018 r.
    Status:
    Published
  11. Cardioprotective flavonoids as a modulators of potassium channels.
    Authors:
    P.Bednarczyk, R.Kampa, A.Sęk, A.Kicińska, B.Kulawiak, W.Jarmuszkiewicz, A.Szewczyk
    Conference:
    7th Mitochondrion 2018 "Mitochondria in the spotlight" (rok: 2018, ), Wydawca: Faculty of Biotechnology University of Wrocław
    Data:
    konferencja 18-19 października 2018 r. Wrocław
    Status:
    Published
  12. Flavonoid-induced changes in oxygen consumption and mitochondrial membrane potential in isolated endothelial mitochondria.
    Authors:
    A.Kicinska, P.Bednarczyk, R.Kampa, A.Szewczyk, W.Jarmuszkiewicz
    Conference:
    3rd Congress of Polish Biosciences BIO2018 Through interdisciplinary approach into new solutions" (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18–21 wrzesnia, 2018 r. Gdańsk
    Status:
    Published
  13. Naringenin as an opener of mitochondrial potassium channels
    Authors:
    P. Bednarczyk, R. P. Kampa, A. Sek, A. Kicinska, W. Jarmuszkiewicz, A. Szewczyk
    Conference:
    44th FEBS CONGRESS (rok: 2019, ), Wydawca: FEBS Open Bio
    Data:
    konferencja 43652
    Status:
    Published
  14. Potassium channels as a target of cytoprotective agents.
    Authors:
    P.Bednarczyk
    Conference:
    XXIV Konferencja Szkoleniowa i XX Konferencja Wspólna Sekcji Elektrokardiologii Nieinwazyjnej i Telemedycyny oraz ISHNE (rok: 2018, ), Wydawca: Polskie Towarzystwo Kardiologiczne
    Data:
    konferencja 28 lutego - 3 marca, 2018, Zakopane
    Status:
    Published
  15. The influence of flavonoids on oxygen consumption and membrane potential of isolated endothelial mitochondria via modulation of mitoBKCa channel activity.
    Authors:
    A.Kicinska, P.Bednarczyk, R.Kampa, A.Szewczyk, W.Jarmuszkiewicz
    Conference:
    20th European Bioenergetics Conference (rok: 2018, ), Wydawca: Elsevier - Biochimica et Biophysica Acta - Bioenergetics
    Data:
    konferencja 25-30 sierpnia, 2018 r. Budapeszt
    Status:
    Published
  16. Beneficial Effect of Citrus Flavonoid - Naringenin on Endothelial Cells by Activation of Mitochondrial Potassium Channels
    Authors:
    Kampa RP. Sek, A. Kicinska A. Daniluk J. Jarmuszkiewicz W. Szewczyk A. Bednarczyk P
    Conference:
    64th Annual Meeting of the Biophysical-Society (rok: 2020, ), Wydawca: BIOPHYSICAL JOURNAL
    Data:
    konferencja FEB 15-19, 2020
    Status:
    Published
  17. Cardioprotective flavoniods as natural modulators of mitochondrial potassium channels.
    Authors:
    R.Kampa, A.Sęk, A.Kicińska, B.Kulawiak, W.Jarmuszkiewicz, A.Szewczyk, P.Bednarczyk
    Conference:
    3rd Congress of Polish Biosciences BIO2018 Through interdisciplinary approach into new solutions" (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18–21 wrzesnia, 2018 r. Gdańsk
    Status:
    Published
  18. Czy flawonoidy mogą regulować aktywność mitochondrialnych kanałów potasowych?
    Authors:
    P.Bednarczyk, R.Kampa, A.Sęk, A.Kicinska, B.Kulawiak, W.Jarmuszkiewicz, A.Szewczyk
    Conference:
    XII Ogólnopolska Konferencja "FLAWONOIDY I ICH ZASTOSOWANIE" (rok: 2018, ), Wydawca: Oficyna Wydawnicza Politechniki Rzeszowskiej
    Data:
    konferencja 9-11 maja 2018 r. Łańcut
    Status:
    Published
  19. Naringenin as natural modulator of mitochondrial potassium channels.
    Authors:
    R.Kampa, A.Szewczyk, P.Bednarczyk
    Conference:
    6th Mitochondrion 2017 "Bioenergetics Update" (rok: 2017, ), Wydawca: Department of Bioenergetics, Institute of Molecular Biology and Biotechnology Faculty of Biology, Adam Mickiewicz University, Poznań
    Data:
    konferencja 8 grudnia 2017 r. Poznań
    Status:
    Published
  20. Direct localization of the BKCa channel in the mitochondria of human bronchial epithelial cell line
    Authors:
    A. Sęk, R. P. Kampa, B. Kulawiak, T. Bauer, A. Szewczyk, P. Bednarczyk
    Conference:
    44th FEBS CONGRESS (rok: 2019, ), Wydawca: FEBS Open Bio
    Data:
    konferencja 43652
    Status:
    Published
  21. Mitochondrial regulation of mitochondrial potassium channels.
    Authors:
    A.Szewczyk, P.Koprowski, B.Kulawiak, P.Bednarczyk
    Conference:
    3rd Congress of Polish Biosciences BIO2018 Through interdisciplinary approach into new solutions" (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18–21 wrzesnia, 2018 r. Gdańsk
    Status:
    Published
  22. Regulation of mitochondrial potassium channels by cardioprotective flavonoids.
    Authors:
    R.Kampa, A.Sęk, A.Kicińska, B.Kulawiak, W.Jarmuszkiewicz, A.Szewczyk, P.Bednarczyk
    Conference:
    7th Mitochondrion 2018 "Mitochondria in the spotlight" (rok: 2018, ), Wydawca: Faculty of Biotechnology University of Wrocław
    Data:
    konferencja 18-19 października 2018 r. Wrocław
    Status:
    Published
  1. Patch-Clamp Recording of the Activity of Ion Channels in the Inner Mitochondrial Membrane
    Authors:
    Bednarczyk P, Kampa RP, Gałecka S, Sek A, Walewska A, Koprowski P
    Book:
    Mitochondrial Medicine (rok: 2021, tom: 2276, strony: 235-248), Wydawca: Springer
    Status:
    Published

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