Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Synteza podwójnie sfunkcjonalizowanych analogów końca 5' mRNA jako sond molekularnych do zastosowań w badaniach komórkowych

2016/20/S/ST5/00364

Keywords:

Descriptors:

  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials
  • ST5_23:
  • NZ1_1: Molecular biology

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Natalia Kleczewska 

Number of co-investigators in the project: 2

Call: FUGA 5 - announced on 2015-12-15

Amount awarded: 612 000 PLN

Project start date (Y-m-d): 2016-10-01

Project end date (Y-m-d): 2019-09-30

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (5)
  1. Cellular delivery of dinucleotides by conjugation with small molecules: targeting translation initiation for anticancer applications
    Authors:
    Natalia Kleczewska, Pawel J Sikorski, Zofia Warminska, Lukasz Markiewicz, Renata Kasprzyk, Natalia Baran, Karina Kwapiszewska, Aneta Karpinska, Jaroslaw Michalski, Robert Holyst, Joanna Kowalska, Jacek Jemielity
    Academic press:
    Chemical Science (rok: 2021, ), Wydawca: Royal Society of Chemistry
    Status:
    Accepted for publication
    DOI:
    10.1039/D1SC02143E - link to the publication
  1. Cell permeable inhibitors of cap dependent translation
    Authors:
    Kleczewska N., Sikorski P. J., Kowalska J., Jemielity J.
    Conference:
    24th Annual Meeting of the RNA Society (rok: 2019, ), Wydawca: RNA Society
    Data:
    konferencja 11-16.06.2019
    Status:
    Published
  2. Design and development of new strategies for mRNA cap analog delivery
    Authors:
    Natalia Kleczewska, Paweł J. Sikorski, Joanna Kowalska, Jacek Jemielity
    Conference:
    19th Tetrahedron Symposium (rok: 2018, ), Wydawca: Elsevier
    Data:
    konferencja 26-29.06.2018
    Status:
    Published
  3. Ligand supported approach for cellular uptake of functionalized 5'cap mRNA
    Authors:
    Natalia Kleczewska, Paweł J. Sikorski, Joanna Kowalska, Jacek Jemielity
    Conference:
    XXIII INTERNATIONAL ROUNDTABLE ON NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS (rok: 2018, ), Wydawca: University of California, San Diego
    Data:
    konferencja 26-30.08.2018
    Status:
    Published
  4. SYNTEZA PODWÓJNIE MODYFIKOWANYCH ANALOGÓW KAPU JAKO SOND MOLEKULARNYCH 5' KOŃCA mRNA
    Authors:
    Natalia Kleczewska, Paweł J. Sikorski, Joanna Kowalska, Jacek Jemielity
    Conference:
    60 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2017, ), Wydawca: Polskie Towarzystwo Chemiczne
    Data:
    konferencja 17-21 września
    Status:
    Published
  5. Cell permeable 5'cap mRNA conjugates as new in-cell translation inhibitors
    Authors:
    Kleczewska N., Sikorski P.J., Kasprzyk R., Warmińska Z., Kowalska J., Jemilelity J.,
    Conference:
    International Summer School on Nucleic Acid Chemistry and Synthetic Biology (rok: 2019, ), Wydawca: Universität Würzburg
    Data:
    konferencja 28.07-02.08.2019
    Status:
    Published