Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Analysis of intracellular and cell free circulating microRNA involved in Treg/Th17 imbalance in patients with Rheumatoid Arthritis (RA).

2015/19/B/NZ5/00247

Keywords:

epigenetics microRNA transcriptional factors cytokines Treg Th17 RA pathogenesis

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Paradowska-Gorycka 

Number of co-investigators in the project: 6

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 921 000 PLN

Project start date (Y-m-d): 2016-09-05

Project end date (Y-m-d): 2021-03-04

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. aparat do real-time PCR (120 000 PLN)
  2. wirówka z chłodzeniem.
  3. Automatyczny czytnik do liczenia komórek.

Information in the final report

  • Publication in academic press/journals (3)
  • Book publications / chapters in book publications (1)
  1. Th17/Treg-Related Transcriptional Factor Expression and Cytokine Profile in Patients With Rheumatoid Arthritis
    Authors:
    Paradowska-Gorycka A, Wajda A, Romanowska-Próchnicka K, Walczuk E, Kuca-Warnawin E, Kmiolek T, Stypinska B, Rzeszotarska E, Majewski D, Jagodzinski PP, Pawlik A.
    Academic press:
    Frontiers in Immunology (rok: 2020, tom: 11, strony: 572858), Wydawca: Frontiers
    Status:
    Published
    DOI:
    fimmu.2020.572858_ - link to the publication
  2. The Interplay between Transcriptional Factors and MicroRNAs as an Important Factor for Th17/Treg Balance in RA Patients.
    Authors:
    Kmiołek T, Rzeszotarska E, Wajda A, Walczuk E, Kuca-Warnawin E, Romanowska-Próchnicka K, Stypinska B, Majewski D, Jagodzinski PP, Pawlik A, Paradowska-Gorycka A.
    Academic press:
    Int J Mol Sci (rok: 2020, tom: 21(19), strony: 7169), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21197169 - link to the publication
  3. miRNAs as Biomarkers and Possible Therapeutic Strategies in Rheumatoid Arthritis.
    Authors:
    Kmiolek T, Paradowska-Gorycka A
    Academic press:
    Cells (rok: 2022, tom: 11(3), strony: 452), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11030452 - link to the publication
  1. MicroRNAs in rheumatoid arthritis: from pathogenesis to clinical utility
    Authors:
    A Paradowska-Gorycka, B. Stypińska
    Book:
    New Developments in the Pathogenesis of Rheumatoid Arthritis (rok: 2017, tom: -, strony: 45376), Wydawca: In Tech
    Status:
    Published

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