Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular mechanism of the toxicity of the antifungal antibiotic amphotericin B

2015/19/B/NZ7/02159

Keywords:

amphotericin B polyene antibiotics biomembranes medical biophysics molecular spectroscopy

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Matematyki, Fizyki i Informatyki

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wiesław Gruszecki 

Number of co-investigators in the project: 7

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 844 200 PLN

Project start date (Y-m-d): 2016-06-15

Project end date (Y-m-d): 2020-06-14

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer stacjonarny z monitorem.
  2. Wyparka rotacyjna.
  3. Laser 405 nm do mikroskopowego systemu ramanowskiego (180 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  1. Modes of the antibiotic activity of amphotericin B against Candida albicans
    Authors:
    Ewa Grela, Agnieszka Zdybicka-Barabas, Bozena Pawlikowska-Pawlega, Malgorzata Cytrynska, Monika Wlodarczyk, Wojciech Grudzinski, Rafal Luchowski, Wieslaw I. Gruszecki
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 17029), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-53517-3 - link to the publication
  2. Mechanism of Binding of Antifungal Antibiotic Amphotericin B to Lipid Membranes: An Insight from Combined Single-Membrane Imaging, Microspectroscopy, and Molecular Dynamics
    Authors:
    Ewa Grela, Miłosz Wieczór, Rafał Luchowski, Joanna Zielinska, Angelika Barzycka, Wojciech Grudzinski, Katarzyna Nowak, Piotr Tarkowski, Jacek Czub and Wieslaw I. Gruszecki
    Academic press:
    Molecular Pharmaceutics (rok: 2018, tom: 15, strony: 4202−4213), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.8b00572 - link to the publication
  3. Self-assembly, stability and conductance of amphotericin B channels: bridging the gap between structure and function
    Authors:
    Joanna Zielińska, Miłosz Wieczór, Paweł Chodnicki, Ewa Grela, Rafał Luchowski, Łukasz Nierzwicki, Tomasz Bączek, Wiesław I. Gruszecki and Jacek Czub
    Academic press:
    Nanoscale (rok: 2021, tom: 13, strony: 3686-3697), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d0nr07707k - link to the publication
  4. ABCA1 transporter reduces amphotericin B cytotoxicity in mammalian cells
    Authors:
    A. Wu,· E. Grela, · K. Wójtowicz, · N. Filipczak,· Y. Hamon, · R. Luchowski, · W. Grudziński,· O. Raducka‑Jaszul, · M. Gagoś, · A. Szczepaniak, · G. Chimini, · W. I. Gruszecki, · T. Trombik
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2019, tom: 76, strony: 4813-5054), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s0001 - link to the publication
  5. Imaging of human cells exposed to an antifungal antibiotic amphotericin B reveals the mechanisms associated with the drug toxicity and cell defence
    Authors:
    Ewa Grela, Mateusz Piet, Rafal Luchowski, Wojciech Grudzinski, Roman Paduch and Wieslaw I. Gruszecki
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 14067), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-018-32301-9 - link to the publication
  6. Molecular organization, localization and orientation of antifungal antibiotic amphotericin B in a single lipid bilayer
    Authors:
    Wojciech Grudzinski, Joanna Sagan, Renata Welc, Rafal Luchowski, Wieslaw I. Gruszecki
    Academic press:
    Scientific Reports (rok: 2016, tom: 6, strony: Article Number: 32780), Wydawca: NATURE PUBLISHING GROUP
    Status:
    Published
    DOI:
    10.1038/srep32780 - link to the publication

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