Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Fibrin clot properties in acute pulmonary embolism.

2015/19/B/NZ5/02215

Keywords:

pulmonary embolism fibrin fibrin clot properties

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Anetta Undas 

Number of co-investigators in the project: 6

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 658 790 PLN

Project start date (Y-m-d): 2016-07-14

Project end date (Y-m-d): 2021-07-13

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. pH-metr (10 000 PLN)
  2. System do dokumentacji i analizy Westrn Blot oraz żeli 1D (140 000 PLN)
  3. Zamrażarka medyczna-86C MDF.
  4. Pipeta Xplorer.
  5. Łaźnia wodna (10 000 PLN)
  6. Spektrofotometr do mikroobjętości (NanoDrop).
  7. Suszarka w punkcie krytycznym.

Information in the final report

  • Publication in academic press/journals (11)
  • Articles in post-conference publications (3)
  1. Effect of enoxaparin on plasma fibrin clot properties and fibrin structure in patients with acute pulmonary embolism
    Authors:
    Michał Ząbczyk, Joanna Natorska, Krzysztof P Malinowski, Anetta Undas
    Academic press:
    Vascul Pharmacol (rok: 2020, tom: 133-134, strony: 106783), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.vph.2020.106783 - link to the publication
  2. Factor XIII and Fibrin Clot Properties in Acute Venous Thromboembolism
    Authors:
    Michał Ząbczyk, Joanna Natorska, Anetta Undas
    Academic press:
    Int J Mol Sci (rok: 2021, tom: 22, strony: 1607), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22041607 - link to the publication
  3. Loose Fibrin Clot Structure and Increased Susceptibility to Lysis Characterize Patients with Central Acute Pulmonary Embolism: The Impact of Isolated Embolism
    Authors:
    Michał Ząbczyk, Joanna Natorska, Agnieszka Janion-Sadowska, Agnieszka Metzgier-Gumiela, Mateusz Polak, Krzysztof Plens, Marianna Janion, Grzegorz Skonieczny, Katarzyna Mizia-Stec, Anetta Undas
    Academic press:
    Thromb Haemost (rok: 2020, tom: brak, strony: brak), Wydawca: Thieme
    Status:
    Published
    DOI:
    10.1055/s-0040-1718762 - link to the publication
  4. Plasma fibrin clot structure and thromboembolism: clinical implications
    Authors:
    Ząbczyk M, Undas A
    Academic press:
    Pol Arch Intern Med (rok: 2017, tom: 127, strony: 873-881), Wydawca: Medycyna Praktyczna
    Status:
    Published
    DOI:
    10.20452/pamw.4165 - link to the publication
  5. Elevated Lactate Levels in Acute Pulmonary Embolism Are Associated with Prothrombotic Fibrin Clot Properties: Contribution of NETs Formation
    Authors:
    Michał Ząbczyk, Joanna Natorska, Agnieszka Janion-Sadowska, Krzysztof P Malinowski, Marianna Janion, Anetta Undas
    Academic press:
    J Clin Med (rok: 2020, tom: 9, strony: 953), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm9040953 - link to the publication
  6. Prothrombotic fibrin clot properties associated with NETs formation characterize acute pulmonary embolism patients with higher mortality risk
    Authors:
    Michał Ząbczyk, Joanna Natorska, Agnieszka Janion-Sadowska, Agnieszka Metzgier-Gumiela, Mateusz Polak, Krzysztof Plens, Marianna Janion, Grzegorz Skonieczny, Katarzyna Mizia-Stec, Anetta Undas
    Academic press:
    Scientific Reports (rok: 2020, tom: 10, strony: 11433), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-020-68375-7 - link to the publication
  7. Right ventricular echocardiographic parameters associated with prothrombotic abnormalities in normotensive patients with acute pulmonary embolism
    Authors:
    Agnieszka Janion-Sadowska, Paweł Rostoff, Michał Ząbczyk, Magdalena Chrapek, Marianna Janion, Anetta Undas
    Academic press:
    International Journal of Cardiology (rok: 2021, tom: 333, strony: 195-201), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijcard.2021.02.087 - link to the publication
  8. Fibrinogen β chain and FXIII polymorphisms affect fibrin clot properties in acute pulmonary embolism
    Authors:
    Adrianna Klajmon, Jakub Chmiel, Michał Ząbczyk, Ewa Wypasek, Krzysztof P. Malinowski, Anetta Undas, Joanna Natorska
    Academic press:
    Eur J Clin Invest (rok: 2021, tom: brak, strony: e13718), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/eci.13718 - link to the publication
  9. Isoprostane-8 and GDF-15 as novel markers of post-PE syndrome: relation with prothrombotic factors
    Authors:
    Michał Ząbczyk, Joanna Natorska, Agnieszka Janion-Sadowska, Agnieszka Metzgier-Gumiela, Mateusz Polak, Krzysztof Plens, Marianna Janion, Grzegorz Skonieczny, Katarzyna Mizia-Stec, Anetta Undas
    Academic press:
    Eur J Clin Invest (rok: 2021, tom: brak, strony: e13660), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/eci.13660 - link to the publication
  10. Plasma fibrin clot proteomics in patients with acute pulmonary embolism: Association with clot properties
    Authors:
    Agata Hanna Bryk, Joanna Natorska, Michał Ząbczyk, Katharina Zettl, Jacek R Wiśniewski, Anetta Undas
    Academic press:
    J Proteomics (rok: 2020, tom: 229, strony: 103946), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jprot.2020.103946 - link to the publication
  11. Plasma fibrin clots of pulmonary embolism patients present increased amounts of factor XIII and alpha2-antiplasmin at 3 months' anticoagulation since the acute phase
    Authors:
    M Zabczyk, J Natorska, Z Bagoly, F Sarkady, B Barath, E Katona, A Bryk, K Zettl, J R Wisniewski, A Undas
    Academic press:
    J Physiol Pharmacol (rok: 2020, tom: 71, strony: 519-524), Wydawca: Polish Physiological Society
    Status:
    Published
    DOI:
    10.26402/jpp.2020.4.07 - link to the publication
  1. Ryzyko wczesnego zgonu w ostrej zatorowości płucnej jest związane z wydłużonym czasem lizy skrzepu: rola NETozy
    Authors:
    Michał Ząbczyk, Joanna Natorska, Agnieszka Janion‑Sadowska, Agnieszka Metzgier‑Gumiela, Marianna Janion, Grzegorz Skonieczny, Anetta Undas
    Conference:
    The 23rd International Congress of the Polish Cardiac Society, September 26–28, 2019, Katowice, Poland (rok: 2019, ), Wydawca: Kardiologia Polska
    Data:
    konferencja 26-28.09.2019
    Status:
    Published
  2. Histidine-rich Glycoprotein Levels Contribute to Prolonged Clot Lysis Time in Acute Pulmonary Embolism
    Authors:
    Patrick Bladek, Michal Zabczyk, Joanna Natorska, Anetta Undas
    Conference:
    International Society on Thrombosis and Haemostasis 2020 Congress (rok: 2020, ), Wydawca: Wiley Online Library
    Data:
    konferencja 12-14.07.2020
    Status:
    Published
  3. Fibrinogen B Arg448Lys and Factor XIII Val34Leu Polymorphisms Are Associated with Prothrombotic Fibrin Clot Properties in Patients with Acute Pulmonary Embolism
    Authors:
    A. Klajmon, J. Chmiel, M. Ząbczyk, J. Natorska, A. Undas
    Conference:
    ISTH Congress (rok: 2021, ), Wydawca: Wiley
    Data:
    konferencja 17-21.07.2021
    Status:
    Published
    DOI:
    link to the publication

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