Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Characteristic of Gaultheria procumbens L. (Ericaceae) as a source of plant-derived substances with potential anti-inflammatory and antioxidant activity.

2015/19/N/NZ7/00959

Keywords:

Gaultheria procumbens anti-inflammatory activity antioxidant activity polyphenols neutrophils

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Farmaceutyczny

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Piotr Michel 

Number of co-investigators in the project: 3

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2016-07-06

Project end date (Y-m-d): 2020-07-05

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Spektrofotometryczny czytnik mikropłytek (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (6)
  1. Salicylate and procyanidin-rich stem extracts of Gaultheria procumbens L. inhibit pro-inflammatory enzymes and suppress pro-inflammatory and pro-oxidant functions of human neutrophils ex vivo.
    Authors:
    Piotr Michel, Sebastian Granica, Anna Magiera, Karolina Rosińska, Małgorzata Jurek, Łukasz Poraj, Monika Anna Olszewska
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20(7), strony: 1753), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20071753 - link to the publication
  2. Biological and chemical insight into Gaultheria procumbens fruits: A rich source of anti-inflammatory and antioxidant salicylate glycosides and procyanidins for food and functional application
    Authors:
    Piotr Michel; Sebastian Granica; Karolina Rosińska; Jarosław Rojek; Łukasz Poraj; Monika Anna Olszewska
    Academic press:
    Food & Function (rok: 2020, tom: 11(9), strony: 7532-7544), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d0fo01750g - link to the publication
  1. (6S, 9R)-vomifoliol from Gaultheria procumbens exhibits anti-oxidant and anti-inflammatory activity in a cellular model of human neutrophils
    Authors:
    Piotr Michel, Sebastian Granica, Anna Wajs-Bonikowska, Monika Anna Olszewska
    Conference:
    4th International Conference on Natural Products Utilization: From plants to pharmacy shelf (rok: 2019, ), Wydawca: Department of Plant Cell Biotechnology and Metabolomics, The Stephan Angeloff Institute of Microbiology
    Data:
    konferencja 29 maja-01 czerwca
    Status:
    Published
  2. Anti-inflammatory and antioxidant activities of methyl salicylate glycosides from Gaultheria procumbens fruit extract
    Authors:
    Piotr Michel; Sebastian Granica; Monika Anna Olszewska
    Conference:
    11th International Symposium on Chromatography of Natural Products (rok: 2018, ), Wydawca: Department of Pharmacognosy with Medicinal Plant Unit; Faculty of Pharmacy; Medical University of Lublin
    Data:
    konferencja 4-7 czerwca
    Status:
    Published
  3. Charakterystyka owoców Gaultheria procumbens L. jako źródła salicylanów o potencjalnej aktywności przeciwzapalnej i przeciwutleniającej
    Authors:
    Piotr Michel, Monika Anna Olszewska
    Conference:
    V Krajowa Konferencja pt.: Naturalne substancje roślinne – aspekty strukturalne i aplikacyjne (rok: 2019, ), Wydawca: Instytut Uprawy Nawożenia i Gleboznawstwa, Państwowy Instytut Badawczy w Puławach
    Data:
    konferencja 18-20 września
    Status:
    Published
  4. Chemical composition, antioxidant and anti-inflammatory activity in human neutrophils of Gaultheria procumbens stem extracts
    Authors:
    Piotr Michel; Monika Anna Olszewska; Sebastian Granica
    Conference:
    GA2018 The 66th Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA); S-TCM 2018 The 11th Shanghai International Conference on Traditional Chinese Medicine and Natural Medicine (rok: 2018, ), Wydawca: Shanghai: The Society for Medicinal Plant and Natural Product Research GA, 2018
    Data:
    konferencja 26-29 września
    Status:
    Published
  5. Charakterystyka gatunku Gaultheria procumbens L. (Ericaceae) jako źródła związków o potencjalnej aktywności przeciwzapalnej i przeciwutleniającej
    Authors:
    Piotr Michel; Monika Anna Olszewska
    Conference:
    IV Krajowa Konferencja pt.: Naturalne Substancje Roślinne. Aspekty Strukturalne i Aplikacyjne (rok: 2017, ), Wydawca: Instytut Uprawy Nawożenia i Gleboznawstwa, Państwowy Instytut Badawczy w Puławach
    Data:
    konferencja 6-8 września
    Status:
    Published
  6. Phenolic constituents of Gaultheria procumbens leaves modulate the pro-inflammatory and pro-oxidant response of human neutrophils
    Authors:
    Piotr Michel, Sebastian Granica, Monika Anna Olszewska
    Conference:
    4th International Conference on Natural Products Utilization: From plants to pharmacy shelf (rok: 2019, ), Wydawca: Department of Plant Cell Biotechnology and Metabolomics, The Stephan Angeloff Institute of Microbiology
    Data:
    konferencja 29 maja-01 czerwca
    Status:
    Published