Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The APOBEC3B deletion - analysis of its role in familial breast cancer predisposition and determination of its consequences on mRNA level

2015/19/N/NZ5/02247

Keywords:

cancer genetics familial predisposition to breast cancer copy number variants association study PCR MLPA ddPCR

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ5_5: Diagnostics in human diseases
  • NZ2_1: Molecular genetics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Klonowska 

Number of co-investigators in the project: 3

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2016-08-09

Project end date (Y-m-d): 2019-08-08

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. komputer wraz z oprogramowaniem (3 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (2)
  1. The 30 kb deletion in the APOBEC3 cluster decreases APOBEC3A and APOBEC3B expression and creates a transcriptionally active hybrid gene but does not associate with breast cancer in the European population
    Authors:
    Klonowska K, Kluzniak W, Rusak B, Jakubowska A, Ratajska M, Krawczynska N, Vasilevska D, Czubak K, Wojciechowska M, Cybulski C, Lubinski J, Kozlowski P
    Academic press:
    Oncotarget (rok: 2017, tom: 8(44), strony: 76357-76374), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.19400 - link to the publication
  2. Large-scale meta-analysis of mutations identified in panels of breast/ovarian cancer-related genes - Providing evidence of cancer predisposition genes
    Authors:
    Suszynska M, Klonowska K, Jasinska AJ, Kozlowski P
    Academic press:
    Gynecologic Oncology (rok: 2019, tom: 153, strony: 452-462), Wydawca: ACADEMIC PRESS INC ELSEVIER SCIENCE
    Status:
    Published
    DOI:
    10.1016/j.ygyno.2019.01.027 - link to the publication
  1. The role of large deletions in BARD1 and APOBEC3B as risk factors for breast and/or ovarian cancer
    Authors:
    Katarzyna Klonowska, Piotr Kozlowski
    Conference:
    9th International Conference of Contemporary Oncology (rok: 2017, ), Wydawca: Termedia
    Data:
    konferencja 22-24.03
    Status:
    Published
  2. The 30 kb deletion in the APOBEC3 cluster decreases APOBEC3A and APOBEC3B expression and creates transcriptionally active hybrid gene but does not associate with breast cancer in European population
    Authors:
    K. Klonowska, W. Kluzniak, B. Rusak, K. Czubak, M. Wojciechowska, M. Ratajska, N. Krawczynska, A. Podolak, D. Vasilevska, J. Limon, C. Cybulski, J. Lubinski, P. Kozlowski
    Conference:
    European Human Genetics Conference 2017 (rok: 2017, ), Wydawca: -
    Data:
    konferencja 27-30.05
    Status:
    Published

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