Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Selective inhibition of NMDAR activity during epileptogenesis as a therapeutic approach to cure epilepsy

2015/19/D/NZ7/02402

Keywords:

NMDAR epileptogenesis temporal lobe epilepsy mossy fibers

Descriptors:

  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Adam Gorlewicz 

Number of co-investigators in the project: 2

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 763 000 PLN

Project start date (Y-m-d): 2016-07-20

Project end date (Y-m-d): 2021-07-19

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zestaw dwóch mikromanipulatorów do patch clamp'a wraz z kontrolerem przesuwu.
  2. Komora międzyfazowa (8 000 PLN)
  3. Pompa perystaltyczna.
  4. Wyciągarka do pipet (32 000 PLN)
  5. Komputerowa stacja do rejestracji i analizy sygnału elektrofizjologicznego i obrazu, wraz z oprogramowaniem i urządzeniami peryferycznymi.
  6. Platforma wraz z komorą zanurzeniową do patch clampa.
  7. Stacja robocza do rejestracji i analizy EEG wraz z oprogramowaniem, monitorem i oprzyrządowaniem (15 000 PLN)
  8. Laser (9 000 PLN)
  9. Pompa infuzyjna (11 000 PLN)
  10. Stół antywibracyjny (20 000 PLN)
  11. Digitalizer do rejestracji sygnału elektrofizjologicznego.
  12. Urządzenie z wibrującym ostrzem (Wibratom) (62 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Colocalization Colormap -an ImageJ Plugin for the Quantification and Visualization of Colocalized Signals
    Authors:
    Adam Gorlewicz, Katarzyna Krawczyk, Andrzej A Szczepankiewicz, Pawel Trzaskoma, Christophe Mulle, Grzegorz M Wilczynski
    Academic press:
    Neuroinformatics (rok: 2020, tom: 18, strony: 661–664), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12021-020-09465-9 - link to the publication
  2. The deletion of GluK2 alters cholinergic control of neuronal excitability
    Authors:
    Adam Gorlewicz, Stefano Zucca, Gael Barthet, Peggy Vincent, Marilena Griguoli, Noëlle Grosjean, Grzegorz Wilczynski, Christophe Mulle
    Academic press:
    Cerebral Cortex (rok: 2021, ), Wydawca: Oxford University Press
    Status:
    Published
  3. Epileptiform GluN2B–driven excitation in hippocampus as a therapeutic target against temporal lobe epilepsy
    Authors:
    Adam Gorlewicz, Barbara Pijet, Krstina Orlova, Leszek Kaczmarek, Ewelina Knapska
    Academic press:
    bioRxive (rok: 2021, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Cold Spring Harbor
    Status:
    Published
    DOI:
    10.1101/2021.06.30.450508 - link to the publication