Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of the neuron-microglia CX3CL1-CX3CR1 and CD200-CD200R protein systems in molecular mechanisms of antipsychotic drug actions: in vivo and in vitro study in the neurodevelopmental models of schizophrenia

2015/19/B/NZ7/02394

Keywords:

neuron-microglia communication fractalkine (CX3CL1) fractalkine receptor (CX3CR1) schizophrenia antipsychotic drugs antigen CD200 antigen receptor CD200R

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_12: Prevention of human diseases
  • NZ3_6: Cell neurobiology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Agnieszka Basta-Kaim 

Number of co-investigators in the project: 5

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 164 868 PLN

Project start date (Y-m-d): 2016-07-20

Project end date (Y-m-d): 2021-07-19

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Kit Startowy Mini & Midi Magnesy do sortowania komórek (16 000 PLN)
  2. Mikrotom z dodatkowym wyposażeniem (90 000 PLN)
  3. Wibratom z wyposażeniem.
  4. Aparat do krojenia tkanek (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (17)
  1. Maternal Immune Activation Sensitizes Male Offspring Rats to Lipopolysaccharide-Induced Microglial Deficits Involving the Dysfunction of CD200-CD200R and CX3CL1-CX3CR1 Systems
    Authors:
    Katarzyna Chamera, Magdalena Szuster-Głuszczak, Ewa Trojan, Agnieszka Basta-Kaim
    Academic press:
    Cells (rok: 2020, tom: 9(7), strony: 45321), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9071676 - link to the publication
  2. Role of Polyinosinic:Polycytidylic Acid-Induced Maternal Immune Activation and Subsequent Immune Challenge in the Behaviour and Microglial Cell Trajectory in Adult Offspring: A Study of the Neurodevelopmental Model of Schizophrenia
    Authors:
    Katarzyna Chamera, Ewa Trojan, Katarzyna Kotarska, Magdalena Szuster-Głuszczak, Natalia Bryniarska, Kinga Tylek, Agnieszka Basta-Kaim
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(4), strony: 45317), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22041558 - link to the publication
  3. Shedding light on the role of CX3CR1 in the pathogenesis of schizophrenia.
    Authors:
    Katarzyna Chamera, Magdalena Szuster-Głuszczak, Agnieszka Basta-Kaim
    Academic press:
    Pharmacological Reports (rok: 2021, tom: 73, strony: 1063–1078), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-021-00269-5 - link to the publication
  4. The prenatal challenge with lipopolysaccharide and polyinosinic:polycytidylic acid disrupts CX3CL1-CX3CR1 and CD200-CD200R signalling in the brains of male rat offspring: a link to schizophrenia-like behaviours
    Authors:
    Katarzyna Chamera, Katarzyna Kotarska, Magdalena Szuster-Głuszczak, Ewa Trojan, Alicja Skórkowska, Bartosz Pomierny, Weronika Krzyżanowska, Natalia Bryniarska, Agnieszka Basta-Kaim
    Academic press:
    Journal of Neuroinflammation (rok: 2020, tom: 17(1), strony: 45315), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12974-020-01923-0 - link to the publication
  5. Quetiapine Ameliorates MIA-Induced Impairment of Sensorimotor Gating: Focus on Neuron-Microglia Communication and the Inflammatory Response in the Frontal Cortex of Adult Offspring of Wistar Rats
    Authors:
    Katarzyna Chamera, Katarzyna Curzytek, Kinga Kamińska, Ewa Trojan, Agnieszka Basta-Kaim
    Academic press:
    Cells (rok: 2022, tom: 11(18), strony: 45313), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11182788 - link to the publication
  6. The Potential Role of Dysfunctions in Neuron - Microglia Communication in the Pathogenesis of Brain Disorders
    Authors:
    Katarzyna Chamera, Ewa Trojan, Magdalena Szuster-Głuszczak and Agnieszka Basta-Kaim
    Academic press:
    Current Neuropharmacology (rok: 2020, tom: 18(5), strony: 408-430), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1570159X17666191113101629 - link to the publication
  1. Maternal immune activation causes deficits in the hippocampal level of CX3CL1 in adult offspring rats – study in the neurodevelopmental model of schizophrenia
    Authors:
    K. Chamera, K. Kotarska, E. Trojan, N. Bryniarska, A. Basta-Kaim
    Conference:
    4th International Conference of Cell Biology (ICCB) (rok: 2018, ), Wydawca: Jagiellonian University in Cracow
    Data:
    konferencja 11-12.05.2018
    Status:
    Published
  2. Maternal immune activation causes disturbances in IL-2 and IL-4 levels in the frontal cortex of young offspring rats
    Authors:
    K. Chamera, K. Kotarska, E. Trojan, N. Bryniarska, A. Basta-Kaim
    Conference:
    3rd Central European Biomedical Congress News on biomarker discovery and research innovations in medicine and biomedical sciences" (rok: 2018, ), Wydawca: Institute of Pharmacology Polish Academy of Sciences in Cracow, Faculty of Medicine Jagiellonian University Medical College
    Data:
    konferencja 15-18.09.2018
    Status:
    Published
  3. PRENATAL PRIMING WITH LIPOPOLYSACCHARIDE ENHANCES THE VULNERABILITY TO THE INFECTIONS IN THE ADULTHOOD – THE STUDY IN THE NEURODEVELOPMENTAL MODEL OF SCHIZOPHRENIA
    Authors:
    Agnieszka Basta-Kaim, Katarzyna Chamera, Magdalena Szuster, Ewa Trojan, Natalia Bryniarska
    Conference:
    The 19th WPA World Congress of Psychiatry, 21-24 August 2019 - Lisbon, Portugal (rok: 2019, ), Wydawca: The Congress Scientific Committee
    Data:
    konferencja 2019-08-21-24
    Status:
    Published
  4. The disturbances of the protein systems controlling neuron – microglia interactions in the frontal cortex of young offspring rats – the comparative study in LPS- and Poly I:C-induced schizophrenia models
    Authors:
    K. Chamera, K. Kotarska, E. Trojan, N. Bryniarska, A. Basta-Kaim
    Conference:
    13th EFIS-EJI Tatra Immunology Conference (rok: 2018, ), Wydawca: European Federation of Immunological Societies, European Journal of Immunology
    Data:
    konferencja 9-13.06.2018
    Status:
    Published
  5. Prenatal exposure to the bacterial endotoxin - lipopolysaccharide causes anxiety like behaviour in an adult offspring rats
    Authors:
    K. Chamera, K. Kotarska, E. Trojan, N. Bryniarska, B. Korzeniak, A. Basta-Kaim
    Conference:
    5th International Conference on Brain Disorders and Therapeutics (rok: 2017, ), Wydawca: conferenceseries.com/OMICS International
    Data:
    konferencja 29-30.11.2017
    Status:
    Published
  6. The effect of prenatal treatment with Poly I:C on CX3CL1 – CX3CR1 signalling in the frontal cortex of adult offspring rats
    Authors:
    K. Chamera, K. Kotarska, E. Trojan, N. Bryniarska, A. Basta-Kaim
    Conference:
    XII Copernican International Young Scientists Conference (CIYSCon) (rok: 2018, ), Wydawca: Nicolaus Copernicus University in Toruń
    Data:
    konferencja 28-29.06.2018
    Status:
    Published
  7. Increased dehydrogenase lactate and nitric oxide release in cortical organotypic cultures obtained from prenatally LPS-treated rat newborns
    Authors:
    K. Kotarska, E. Trojan, K. Chamera, N. Bryniarska, A. Basta-Kaim
    Conference:
    XLVth Winter School of Faculty of Biochemistry, Biophysics and Biotechnology of the Jagiellonian University in Kraków Signaling – from molecules to cells and back" (rok: 2018, ), Wydawca: Jagiellonian University in Cracow
    Data:
    konferencja 9-14.02.2018
    Status:
    Published
  8. Quetiapine reverses the malfunctions in the behaviour and the neuron-microglia protein systems of prenatally LPS-treated offspring
    Authors:
    K. Chamera, M. Szuster, E. Trojan, A. Basta-Kaim
    Conference:
    2019 ISN-ASN Meeting (rok: 2019, ), Wydawca: International Society for Neurochemistry (ISN), American Society for Neurochemistry (ASN)
    Data:
    konferencja 2019-08-04-08
    Status:
    Published
  9. The neurodevelopmental animal models of schizophrenia based on prenatal immunoactivation as an essential tool to the study of biological basis of this disease
    Authors:
    K. Chamera, K. Kotarska, E. Trojan, N. Bryniarska, B. Korzeniak, A. Basta-Kaim
    Conference:
    7th Conference Aspects of Neuroscience (rok: 2017, ), Wydawca: Faculty of Biology, University of Warsaw
    Data:
    konferencja 24-26.11.2017
    Status:
    Published
  10. Increased levels of IL-6 and TNF-α in cortical organotypic cultures – study in the animal model of schizophrenia
    Authors:
    K. Chamera, E. Trojan, K. Kotarska, N. Bryniarska, A. Basta-Kaim
    Conference:
    XLVth Winter School of Faculty of Biochemistry, Biophysics and Biotechnology of the Jagiellonian University in Kraków Signaling – from molecules to cells and back" (rok: 2018, ), Wydawca: Jagiellonian University in Cracow
    Data:
    konferencja 9-14.02.2018
    Status:
    Published
  11. Influence of the maternal immunoactivation on the neuron-microglia interactions in young offspring
    Authors:
    A. Basta-Kaim, B. Budziszewska, K. Kotarska, K. Chamera, E. Trojan, N. Bryniarska
    Conference:
    18th World Congress of Basic and Clinical Pharmacology (WCP2018) (rok: 2018, ), Wydawca: 18th World Congress of Basic and Clinical Pharmacology
    Data:
    konferencja 1-6.06.2018
    Status:
    Published
  12. Określenie wpływu immunoaktywacji matki na zaburzenia behawioralne potomstwa
    Authors:
    K. Chamera, K. Kotarska, E. Trojan, N. Bryniarska, A. Basta-Kaim
    Conference:
    X Interdyscyplinarna konferencja naukowa TYGIEL: Interdyscyplinarność kluczem do rozwoju" (rok: 2018, ), Wydawca: Fundacja na rzecz promocji nauki i rozwoju TYGIEL
    Data:
    konferencja 17-18.03.2018
    Status:
    Published
  13. Prenatal exposure to Poly I:C causes changes in the hippocampal level of CX3CR1 of young offspring rats
    Authors:
    K. Chamera, K. Kotarska, E. Trojan, N. Bryniarska, A. Basta-Kaim
    Conference:
    Neuronus IBRO Neuroscience Forum (rok: 2018, ), Wydawca: Jagiellonian University in Cracow
    Data:
    konferencja 20-22.04.2018
    Status:
    Published
  14. The exposure to the viral component Poly I:C leads to an elevation of CX3CL1 level in cortical organotypic cultures
    Authors:
    Katarzyna Chamera, Magdalena Szuster, Ewa Trojan, Agnieszka Basta-Kaim
    Conference:
    Workshop on Glial Cells-Neuron Crosstalk in CNS Health and Disease (rok: 2020, ), Wydawca: Uniwersytet w Turynie i Neuroscience Institute Cavalieri Ottolenghi
    Data:
    konferencja 1-3.10.2020
    Status:
    Published
  15. The impact of priming with MIA on the brain immune status and behaviour of the adult Sprague-Dawley offspring
    Authors:
    Katarzyna Chamera, Magdalena Szuster, Ewa Trojan, Agnieszka Basta-Kaim
    Conference:
    FENS 2020 Virtual Forum (rok: 2020, ), Wydawca: FENS
    Data:
    konferencja 11-15.07.2020
    Status:
    Published
  16. The influence of maternal immune activation with Poly I:C on the social behavior of the adult rat offspring
    Authors:
    K. Kotarska, K. Chamera, E. Trojan, N. Bryniarska, B. Korzeniak, A. Basta-Kaim
    Conference:
    7th Conference Aspects of Neuroscience (rok: 2017, ), Wydawca: Faculty of Biology, University of Warsaw
    Data:
    konferencja 24-26.11.2017
    Status:
    Published
  17. Maternal lipopolysaccharide treatment induces a shift in microglia, suppressing the anti-inflammatory response in young offspring brain
    Authors:
    A. Basta-Kaim, K. Chamera, E. Trojan, M. Szuster, N. Bryniarska
    Conference:
    7th Mediterranean Neuroscience Conference (MNS) (rok: 2019, ), Wydawca: Mediterranean Neuroscience Society (MNS)
    Data:
    konferencja 2019-06-23-27
    Status:
    Published

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