Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Search for alternative signaling pathway associated with pathogenesis of tuberous sclerosis complex.

2015/19/B/NZ5/02229

Keywords:

tuberous sclerosis pathogenesis signalling pathway microRNA metabolome

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_5: Diagnostics in human diseases
  • NZ2_1: Molecular genetics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski, I Katedra Pediatrii, Klinika Pediatrii, Onkologii, Hematologii i Diabetologii

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Joanna Trelińska 

Number of co-investigators in the project: 8

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 645 000 PLN

Project start date (Y-m-d): 2016-07-08

Project end date (Y-m-d): 2020-07-07

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Laptop (3 500 PLN)
  2. skaner do automatycznego tranferu białek (11 500 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (1)
  1. A multistep approach to the genotype-phenotype analysis of Polish patients with tuberous sclerosis complex
    Authors:
    Katarzyna Bąbol-Pokora, Marta Bielska, Katarzyna Bobeff, Izabela Jatczak-Pawlik, Julita Borkowska, Katarzyna Kotulska, Sergiusz Jóźwiak, Wojciech Młynarski, Joanna Trelińska
    Academic press:
    European Journal of Medical Genetics (rok: 2021, tom: 64, strony: 45299), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmg.2021.104309 - link to the publication
  2. What are the true volumes of SEGA tumors? Reliability of planimetric and popular semi-automated image segmentation methods.
    Authors:
    Stawiski K, Trelińska J, Baranska D, Dachowska I, Kotulska K, Jóźwiak S, Fendler W, Młynarski W.
    Academic press:
    MAGMA (rok: 2017, tom: 30, strony: 397-4405), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10334-017-0614-3 - link to the publication
  3. mTOR inhibitor treatment in patients with tuberous sclerosis complex is associated with specific changes in microRNA serum profile.
    Authors:
    Bartłomiej Pawlika, Urszula Smyczyńska, Szymon Grabia, Wojciech Fendler, Izabela Dróżdż, Katarzyna Bąbol-Pokora, Katarzyna Kotulska, Sergiusz Jóźwiak, Julita Borkowska, Wojciech Młynarski, Joanna Trelińska
    Academic press:
    Journal of Clinical Medicine (rok: 2022, tom: 11(12):3395, strony: 45301), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm11123395 - link to the publication
  4. Maintenance Therapy with Everolimus for Subependymal Giant Cell Astrocytoma in Patients with Tuberous Sclerosis (the EMINENTS study)
    Authors:
    Joanna Trelinska, Iwona Dachowska, Dobromila Baranska, Konrad Stawiski, Katarzyna Kotulska, Wojciech Fendler, Sergiusz Jozwiak, Wojciech Mlynarski
    Academic press:
    Pediatric Blood and Cancer (rok: 2017, tom: 64(6), strony: e26347), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/pbc.26347 - link to the publication
  5. New insights into red blood cell microcytosis upon mTOR inhibitor administration
    Authors:
    Justyna Jakubowska, Bartłomiej Pawlik, Krystyna Wyka, Małgorzata Stolarska, Katarzyna Kotulska, Sergiusz Jóźwiak, Wojciech Młynarski, Joanna Trelińska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 45304), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22136802 - link to the publication
  6. Maintenance Therapy with Everolimus for Subependymal Giant Cell Astrocytoma in Patients with Tuberous Sclerosis – Final Results from the EMINENTS Study
    Authors:
    Katarzyna Bobeff, Karolina Krajewska, Dobromiła Barańska, Katarzyna Kotulska, Sergiusz Jóźwiak, Wojciech Młynarski, Joanna Trelińska
    Academic press:
    Fronitiers in Neurology (rok: 2021, tom: 12, strony: 45301), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fneur.2021.581102 - link to the publication
  1. Efficacy and Safety of Everolimus Maintenance Therapy for Subependymal Giant Cell Astrocytoma in Tuberous Sclerosis: A Sinble Center, Prospective Intervention "Eminenets Study".
    Authors:
    Trelińska J., Dachowska I., Fendler W., Bobeff K., Barańska D., Kotulska K., Jóźwiak S., Młynarski W.
    Conference:
    50th Congress of the International Society of Paediatric Oncology (SIOP) (rok: 2018, ), Wydawca: Wiley Periodicals, Inc.
    Data:
    konferencja 16-19.11.2018
    Status:
    Published

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