Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The role of MCPIP1 protein in growth, progression and vascularisation of clear cell renal cell carcinoma.

2015/19/B/NZ5/01405

Keywords:

MCPIP1 protein tumor growth metastasis angiogenesis

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Katarzyna Miękus 

Number of co-investigators in the project: 7

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 788 400 PLN

Project start date (Y-m-d): 2016-06-23

Project end date (Y-m-d): 2021-06-22

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. komputer (5 000 PLN)
  2. lodówka (3 000 PLN)
  3. cytometr przepływowy (160 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (1)
  1. C-Met as a Key Factor Responsible for Sustaining Undifferentiated Phenotype and Therapy Resistance in Renal Carcinomas
    Authors:
    Paulina Marona , Judyta Górka, Jerzy Kotlinowski, Marcin Majka , Jolanta Jura, Katarzyna Miekus
    Academic press:
    Cells (rok: 2019, tom: 272, strony: 8; MDPI używa nr artykułów, zamiast nr stron), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8030272 - link to the publication
  2. MCPIP1 inhibits Wnt/β-catenin signaling pathway activity and modulates epithelial-mesenchymal transition during clear cell renal cell carcinoma progression by targeting miRNAs
    Authors:
    Judyta Gorka, Paulina Marona, Oliwia Kwapisz, Agnieszka Waligórska, Ewelina Pospiech, Jurek W Dobrucki, Janusz Rys, Jolanta Jura, Katarzyna Miekus
    Academic press:
    Oncogene (rok: 2021, tom: 50, strony: 6720-6735), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41388-021-02062-3 - link to the publication
  3. The anti-inflammatory protein MCPIP1 inhibits the development of ccRCC by maintaining high levels of tumour suppressors
    Authors:
    Judyta Gorka, Paulina Marona, Oliwia Kwapisz, Janusz Rys, Jolanta Jura, Katarzyna Miekus
    Academic press:
    European Journal of Pharmacology (rok: 2020, tom: 888, strony: 173591), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016􏱝􏰎.e􏰎phar.2020.173591 - link to the publication
  4. MCPIP1 downregulation in clear cell renal cell carcinoma promotes vascularization and metastatic progression
    Authors:
    Marona P, Górka J., Mazurek Z, Wilk W, Rys J, Majka M, Jura J, Miekus K
    Academic press:
    Cancer Research (rok: 2017, tom: Sep 15;77(18), strony: 4905-4920), Wydawca: AACR
    Status:
    Published
    DOI:
    10.1158/0008-5472 - link to the publication
  1. RNase activity of MCPIP1 regulates key elements of mesenchymal phenotype of clear cell renal cell carcinoma cells
    Authors:
    Miekus, K; Marona, P ; Gorka, J; Jura, J
    Conference:
    Annual Meeting of the American-Association-for-Cancer-Research (AACR) (rok: 2018, ), Wydawca: Cancer Research
    Data:
    konferencja APR 14-18, 2018
    Status:
    Published
    DOI:
    link to the publication

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