Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Regulatory Networks of the eukaryotic Elongator Complex

2015/19/B/NZ1/00343

Keywords:

tRNA modification crystal structure Elongator Kti-proteins electron microscopy neurodegenerative diseases

Descriptors:

  • NZ1_4: Structural biology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Sebastian Glatt 

Number of co-investigators in the project: 5

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 639 600 PLN

Project start date (Y-m-d): 2016-06-24

Project end date (Y-m-d): 2020-01-23

Project duration:: 43 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. urządzenie do automatycznego zamrażania typu plunge freezing (250 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Book publications / chapters in book publications (1)
  1. Molecular basis of tRNA recognition by the Elongator complex
    Authors:
    Dauden MI, Jaciuk M, Weis F, Lin TY, Kleindienst C, El Abbassi N, Krutyhołowa R, Breunig K, Kosinski J, Müller CW and Glatt S
    Academic press:
    Science Advances (rok: 2019, tom: 5(7), strony: epub), Wydawca: American Association for the Advancement of Science (AAAS)
    Status:
    Published
    DOI:
    10.1126/sciadv.aaw2326 - link to the publication
  2. Use of a Yeast tRNase Killer Toxin to Diagnose Kti12 Motifs Required for tRNA Modification by Elongator
    Authors:
    Constance Mehlgarten, Heike Prochaska, Alexander Hammermeister, Wael Abdel-Fattah, MelanieWagner, Roscisław Krutyhołowa, Sang Eun Jun, Gyung-Tae Kim, Sebastian Glatt, Karin D. Breunig, Michael J. R. Stark and Raffael Schaffrath
    Academic press:
    Toxins (rok: 2017, tom: 9(9), strony: E272), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/toxins9090272 - link to the publication
  3. Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator
    Authors:
    Rościsław Krutyhołowa, Alexander Hammermeister, Rene Zabel, Wael Abdel-Fattah, Annekathrin Reinhardt-Tews, Mark Helm, Michael J. R. Stark, Karin D. Breunig, Raffael Schaffrath* and Sebastian Glatt*
    Academic press:
    Nucleic Acids Research (rok: 2019, tom: 47(9), strony: 4814-4830), Wydawca: Oxford University Press (OUP)
    Status:
    Published
    DOI:
    10.1093/nar/gkz190 - link to the publication
  4. Structure and Function of tRNA modifiers
    Authors:
    Krutyhołowa R, Zakrzewski K and Glatt S
    Academic press:
    Current Opinion in Structural Biology (rok: 2019, tom: 55, strony: 138-146), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.sbi.2019.03.014 - link to the publication
  5. The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase
    Authors:
    Ting-Yu Lin, Nour El Hana Abbassi, Karol Zakrzewski, Andrzej Chramiec- Głąbik, Małgorzata Jemioła-Rzemińska, Jan Różycki and Sebastian Glatt
    Academic press:
    Nature Communications (rok: 2019, tom: 10(1), strony: 625), Wydawca: Springer Nature Limited
    Status:
    Published
    DOI:
    10.1038/s41467-019-08579-2. - link to the publication
  6. Architecture of the yeast Elongator complex
    Authors:
    Maria I Dauden, Jan Kosinski, Olga Kolaj-Robin, Ambroise Desfosses, Alessandro Ori, Celine Faux, Niklas A Hoffmann, Osita F Onuma, Karin D Breunig , Martin Beck , Carsten Sachse , Bertrand Séraphin, Sebastian Glatt* and Christoph W Müller*
    Academic press:
    EMBO Reports (rok: 2017, tom: 18(2), strony: 264-279), Wydawca: EMBO
    Status:
    Published
    DOI:
    10.15252/embr.201643353 - link to the publication
  7. Structural asymmetry in the eukaryotic Elongator complex
    Authors:
    Maria I Dauden, Marcin Jaciuk, Christoph W. Mueller and Sebastian Glatt
    Academic press:
    FEBS Letters (rok: 2017, tom: Special Issue, strony: 1), Wydawca: FEBS Press
    Status:
    Published
    DOI:
    10.1002/1873-3468.12865 - link to the publication
  1. tRNA modification by Elongator protein 3 (Elp3)
    Authors:
    Ting-Yu Lin and Sebastian Glatt
    Book:
    Encyclopedia of Inorganic and Bioinorganic Chemistry (rok: 2018, tom: online, strony: online), Wydawca: John Wiley & Sons
    Status:
    Published

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