Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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MCPIP1 as an important regulator of development and progression of non-alcoholic fatty liver disease.

2015/19/D/NZ5/00254

Keywords:

MCPIP1 inflammation NAFLD

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Jerzy Kotlinowski 

Number of co-investigators in the project: 5

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 680 000 PLN

Project start date (Y-m-d): 2016-06-13

Project end date (Y-m-d): 2020-05-12

Project duration:: 47 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Monitor, przenośny dysk, myszka, klawiatura.
  2. NanoDrop (45 000 PLN)
  3. pompa perystaltyczna.
  4. zamrażarka -20 (3 000 PLN)
  5. Laptop (5 000 PLN)
  6. zestaw do analizy western blot (15 000 PLN)
  7. zestaw pipet (5 000 PLN)
  8. Program GraphPad Prism (2 szt.) (3 400 PLN)
  9. pojemnik (dewar) na ciekły azot.
  10. zamrażarka.

Information in the final report

  • Publication in academic press/journals (7)
  1. A Novel Monoallelic Nonsense Mutation in the NFKB2 Gene Does Not Cause a Clinical Manifestation.
    Authors:
    1.Kotlinowski J, Bukowska-Strakova K, Koppolu A, Kosińska J, Pydyn N, Stawinski P, Wilamowski M, Nowak W, Józkowicz A, Baran J, Płoski R and Jura J
    Academic press:
    Frontiers in Genetics (rok: 2019, tom: 10, strony: 140), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fgene.2019.00140 - link to the publication
  2. RNase MCPIP1 regulates hepatic peroxisome proliferator-activated receptor gamma via TXNIP/PGC-1alpha pathway.
    Authors:
    Natalia Pydyn, Justyna Kadluczka, Edyta Kus, Ewelina Pospiech, Magdalena Losko, Mingui Fu, Jolanta Jura, Jerzy Kotlinowski
    Academic press:
    BBA - Molecular and Cell Biology of Lipids (rok: 2019, tom: 1864(10), strony: 1458-1471), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbalip.2019.06.006. - link to the publication
  3. Role of Mcpip1 in obesity-induced hepatic steatosis as determined by myeloid and liver specific conditional knockouts.
    Authors:
    Natalia Pydyn, Dariusz Żurawek, Joanna Kozieł, Edyta Kuś, Mingui Fu, Stefan Chłopicki, Jolanta Jura, Jerzy Kotlinowski
    Academic press:
    The FEBS Journal (rok: 2021, tom: 288, strony: Online ahead of print), Wydawca: John Wiley & Sons, Inc
    Status:
    Published
    DOI:
    10.1111/febs.16040 - link to the publication
  4. Deletion of Mcpip1 in Mcpip1AlbKO mice recapitulates the phenotype of human primary biliary cholangitis
    Authors:
    Jerzy Kotlinowski, Tomasz Hutsch, Izabela CzyzynskaCichon, Marta Wadowska, Natalia Pydyn, Agnieszka Jasztal, Agnieszka Kij, Ewelina Dobosz, Maciej Lech, Katarzyna Miekus, Ewelina Pośpiech, Mingui Fu, Jolanta Jura, Joanna Koziel, Stefan Chlopicki
    Academic press:
    Biochim Biophys Acta Mol Basis Dis (rok: 2021, tom: 1867, strony: 166086), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2021.166086 - link to the publication
  5. RNAza MCPIP1 jako istotny regulator wewnątrzkomórkowej puli RNA
    Authors:
    Natalia Pydyn, Katarzyna Miękus, Jerzy Kotlinowski
    Academic press:
    Postępy Higieny i Medycyny Doświadczalnej (rok: 2018, tom: 72, strony: 350-358), Wydawca: Instytut Immunologii i Terapii Doświadczalnej Polskiej Akademii Nauk im. Ludwika Hirszfelda
    Status:
    Published
    DOI:
    brak - link to the publication
  6. PPAR Gamma and Angiogenesis: Endothelial Cells Perspective
    Authors:
    Jerzy Kotlinowski, Alicja Jozkowicz
    Academic press:
    Journal of Diabetes Research (rok: 2016, tom: 2016, strony: 45302), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2016/8492353 - link to the publication
  7. New therapeutic strategies in nonalcoholic fatty liver disease: a focus on promising drugs for nonalcoholic steatohepatitis
    Authors:
    Natalia Pydyn, Katarzyna Miękus, Jolanta Jura, Jerzy Kotlinowski
    Academic press:
    Pharmacological Reports (rok: 2020, tom: 72, strony: 45303), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-019-00020-1 - link to the publication

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