Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of Snail-1 and Cx43 in regulation of invasive properties of human glioblastoma multiforme

2015/19/D/NZ3/00273

Keywords:

glioma glioblastoma multiforme Snail-1 Cx43 cancer invasion

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_6: Cell neurobiology
  • NZ3_2: Cell physiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Damian Ryszawy 

Number of co-investigators in the project: 4

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 694 000 PLN

Project start date (Y-m-d): 2016-07-07

Project end date (Y-m-d): 2020-05-06

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wibratom Leica VT 1200 (65 000 PLN)
  2. Komora laminarna II klasy (35 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  1. Therapeutic potential of monoterpene α-thujone, the main compound of Thuja occidentalis L. essential oil, against malignant glioblastoma multiforme cells in vitro
    Authors:
    Maciej Pudełek, Jessica Catapano, Paweł Kochanowski, Krzysztof Mrowiec, Natalia Janik-Olchawa, Jarosław Czyż, Damian Ryszawy
    Academic press:
    Fitoterapia (rok: 2019, tom: 134, strony: 172-181), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fitote.2019.02.020 - link to the publication
  2. Explant-like passaging of cells growing on portable substrata permits the avoidance of enzyme application and facilitates the passage procedure
    Authors:
    Damian Ryszawy, Justyna Podulka, Anna Tworzydło, Justyna Tomassy, Michał Jarmulski, Włodzimierz Korohoda
    Academic press:
    Folia Biologica (rok: 2019, tom: 67, strony: 169-176), Wydawca: Institute of Systematics and Evolution of Animals, Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.3409/fb_67-4.17 - link to the publication
  3. High bisphenol A concentrations augment the invasiveness of tumor cells through Snail-1/Cx43/ERRγ-dependent epithelial-mesenchymal transition
    Authors:
    Damian Ryszawy, Maciej Pudełek, Paweł Kochanowski, Natalia Janik-Olchawa, Joanna Bogusz, Michał Rąpała, Paulina Koczurkiewicz, Justyna Mikołajczyk, Izabela Borek, Sylwia Kędracka-Krok, Elżbieta Karnas, Ewa Zuba-Surma, Zbigniew Madeja, Jarosław Czyż
    Academic press:
    Toxicology in Vitro (rok: 2020, tom: 62, strony: 104676), Wydawca: Pergamon
    Status:
    Published
    DOI:
    10.1016/j.tiv.2019.104676 - link to the publication
  4. Temozolomide Induces the Acquisition of Invasive Phenotype by O6-Methylguanine-DNA Methyltransferase (MGMT) + Glioblastoma Cells in a Snail-1/Cx43-Dependent Manner
    Authors:
    Kochanowski P, Catapano J, Pudełek M, Wróbel T, Madeja Z, Ryszawy D, Czyż J
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(8), strony: 4150), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22084150 - link to the publication
  5. Bioinspired Bola-Type Peptide Dendrimers Inhibit Proliferation and Invasiveness of Glioblastoma Cells in a Manner Dependent on Their Structure and Amphipathic Properties
    Authors:
    Cieślak M, Ryszawy D, Pudełek M, Urbanowicz M, Morawiak M, Staszewska-Krajewska O, Czyż J, Urbańczyk-Lipkowska Z
    Academic press:
    Pharmaceutics (rok: 2021, tom: 8;12(11), strony: 1106), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics12111106 - link to the publication
  6. High doses of sodium ascorbate interfere with the expansion of glioblastoma multiforme cells in vitro and in vivo
    Authors:
    Damian Ryszawy, Maciej Pudełek, Jessica Catapano, Małgorzata Ciarach, Zuzanna Setkowicz, Ewa Konduracka, Zbigniew Madeja, Jarosław Czyż
    Academic press:
    Life sciences (rok: 2019, tom: 232, strony: 116657), Wydawca: Pergamon
    Status:
    Published
    DOI:
    10.1016/j.lfs.2019.116657 - link to the publication
  7. Connexin-dependent intercellular stress signaling in tissue homeostasis and tumor development
    Authors:
    Jarosław Czyż, Katarzyna Piwowarczyk, Milena Paw, Marcin Luty, Tomasz Wróbel, Jessica Catapano, Zbigniew Madeja, Damian Ryszawy
    Academic press:
    Acta Biochimica Polonica (rok: 2017, tom: 64, strony: 45304), Wydawca: Polish Biochemical Society
    Status:
    Published
    DOI:
    10.18388/abp.2017_1592 - link to the publication
  8. Epidermal Growth Factor (EGF) Augments the Invasive Potential of Human Glioblastoma Multiforme Cells via the Activation of Collaborative EGFR/ROS-Dependent Signaling
    Authors:
    Maciej Pudełek, Kamila Król, Jessica Catapano, Tomasz Wróbel, Jarosław Czyż, Damian Ryszawy
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 3605), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms21103605 - link to the publication
  9. Invasive bronchial fibroblasts derived from asthmatic patients activate lung cancer A549 cells in vitro
    Authors:
    Damian Ryszawy, Filip Rolski, Karolina Ryczek, Jessica Catapano, Tomasz Wróbel, Marta Michalik, Jarosław Czyż
    Academic press:
    Oncology letters (rok: 2018, tom: 16, strony: 6582-6588), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ol.2018.9462 - link to the publication

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