Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Mechanisms protecting from oxidative damage during aging

2015/19/B/NZ1/03444

Keywords:

aging mitochondria oxidation protein synthesis thiol-modification translation

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_1: Molecular biology
  • NZ3_4: Ageing

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ulrike Topf 

Number of co-investigators in the project: 3

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 200 800 PLN

Project start date (Y-m-d): 2016-09-30

Project end date (Y-m-d): 2020-11-29

Project duration:: 50 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zasilacz do elektroforezy (2 szt.).
  2. Komputery (2 szt.) (16 500 PLN)
  3. Pompa próżniowa (8 100 PLN)
  4. Zamrażarka -20 (3 000 PLN)
  5. Suszarka do żeli poliakrylamidowych (11 500 PLN)
  6. Aparat do elektroforezy (2 600 PLN)
  7. Kaseta do odczytu wyznakowanych białek (12 500 PLN)
  8. Termomikser.

Information in the final report

  • Publication in academic press/journals (7)
  1. Ancient function of teneurins in tissue organization and neuronal guidance in the nematode Caenorhabditis elegans
    Authors:
    Topf U. and Drabikowski K.
    Academic press:
    Frontiers in Neuroscience (rok: 2019, tom: 13, strony: NA), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fnins.2019.00205 - link to the publication
  2. Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish
    Authors:
    Sokol A.M., Uszczynska-Ratajczak B., Collins M.M., Bazala M., Topf U., Lundegaard P.R., Sugunan S., Guenther S., Kuenne C., Graumann J., Chan S.S.L., Stainier D.Y.R., Chacinska A.
    Academic press:
    PLOS Genetics (rok: 2018, tom: 14(11), strony: e1007743), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pgen.1007743 - link to the publication
  3. Eukaryotic Elongation Factor 3 Protects Saccharomyces cerevisiae Yeast from Oxidative Stress
    Authors:
    Karolina Gościńska, Somayeh Shahmoradi Ghahe, Sara Domogała, Ulrike Topf
    Academic press:
    Genes (Basel) (rok: 2020, tom: 11(12), strony: 1432), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes11121432 - link to the publication
  4. Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans
    Authors:
    Maria Sladowska, Michał Turek, Min-Ji Kim, Krzysztof Drabikowski, Ben Hur Marins Mussulini, Karthik Mohanraj, Remigiusz A Serwa, Ulrike Topf, Agnieszka Chacinska
    Academic press:
    PLoS Biology (rok: 2021, tom: 19(7), strony: e3001302), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pbio.3001302 - link to the publication
  5. The evolving role of ribosomes in the regulation of protein synthesis
    Authors:
    Karolina Gościńska, Ulrike Topf
    Academic press:
    Acta Biochim Pol (rok: 2020, tom: 67, strony: 5384), Wydawca: Acta Biochim Pol
    Status:
    Published
    DOI:
    10.18388/abp.2020_5384 - link to the publication
  6. Mitochondrial stress-dependent regulation of cellular protein synthesis
    Authors:
    Topf U., Uszczynska-Ratajczak B., Chacinska A.
    Academic press:
    Journal of Cell Science (rok: 2019, tom: 8, strony: jcs226258), Wydawca: The Company of Biologists
    Status:
    Published
    DOI:
    10.1242/jcs.226258 - link to the publication
  7. Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species.
    Authors:
    Topf U., Suppanz I., Wrobel L., Böser A., Samluk L., Sakowska P., Knapp B., Chacinska A., Warscheid B.
    Academic press:
    Nature Communications (rok: 2018, tom: 9(1), strony: 324), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41467-017-02694-8 - link to the publication

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