Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Yeast model to study function of Vps13 proteins involved in pathogenesis of rare genetic neurodegenerative diseases.

2015/19/B/NZ3/01515

Keywords:

Vps13 chorea acanthocytosis Cohen syndrom membrane contact sites

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_2: Cell physiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Teresa Żołądek 

Number of co-investigators in the project: 6

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 971 280 PLN

Project start date (Y-m-d): 2016-06-20

Project end date (Y-m-d): 2020-06-19

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Dysruptor (6 000 PLN)
  2. Zestaw komputerowy (10 000 PLN)
  3. Rotor (9 000 PLN)
  4. zestaw komputerowy.
  5. Kołyska laboratoryjna (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  • Articles in post-conference publications (5)
  1. Białka z rodziny Vps13 – od funkcji molekularnej do patogenezy chorób neurodegeneracyjnych
    Authors:
    Joanna Kamińska, Damian Kołakowski
    Academic press:
    Postępy Biochemii (rok: 2018, tom: 64, strony: 276-287), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2018_141 - link to the publication
  2. Amino acid substitution equivalent to human choreaacanthocytosis I2771R in yeast Vps13 protein affects its binding to phosphatidylinositol 3-phosphate.
    Authors:
    RZEPNIKOWSKA W., FLIS K., KAMIŃSKA J., GRYNBERG M., URBANEK A., AYSCOUGH K., ŻOŁĄDEK T.
    Academic press:
    Human Molecular Genetics (rok: 2017, tom: 26(8), strony: 1497-1510), Wydawca: OXFORD
    Status:
    Published
    DOI:
    10.1093/hmg/ddx054 - link to the publication
  3. Flavonoids as Potential Drugs for VPS13-Dependent Rare Neurodegenerative Diseases
    Authors:
    Piotr Soczewka , Krzysztof Flis , Déborah Tribouillard-Tanvier , Jean-Paul di Rago , Cláudia N. Santos , Regina Menezes , Joanna Kaminska and Teresa Zoladek
    Academic press:
    Genes (rok: 2020, tom: 11(7), strony: E828), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes11070828 - link to the publication
  4. Yeast-model-based study identified myosin- and calciumdependent calmodulin signalling as a potential target for drug intervention in chorea-acanthocytosis
    Authors:
    Piotr Soczewka, Damian Kolakowski, Iwona Smaczynska-de Rooij, Weronika Rzepnikowska, Kathryn R. Ayscough, Joanna Kaminska and Teresa Zoladek
    Academic press:
    Disease Models & Mechanisms (rok: 2019, tom: 12, strony: 45306), Wydawca: The Company of Biologists
    Status:
    Published
    DOI:
    10.1242/dmm.036830 - link to the publication
  5. Targeting Copper Homeostasis Improves Functioning of vps13D Yeast Mutant Cells, a Model of VPS13-Related Diseases
    Authors:
    Piotr Soczewka, Déborah Tribouillard-Tanvier, Jean-Paul di Rago, Teresa Zoladek, Joanna Kaminska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 45316), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22052248 - link to the publication
  6. The GTPase Arf1 Is a Determinant of Yeast Vps13 Localization to the Golgi Apparatus
    Authors:
    Damian Kolakowski, Weronika Rzepnikowska, Aneta Kaniak-Golik, Teresa Zoladek, Joanna Kaminska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 45311), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222212274 - link to the publication
  7. Partial Inhibition of Calcineurin Activity by Rcn2 as a Potential Remedy for Vps13 Deficiency
    Authors:
    Patrycja Wardaszka , Piotr Soczewka, Marzena Sienko, Teresa Zoladek , Joanna Kaminska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 45308), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22031193 - link to the publication
  8. The binding of the APT1 domains to phosphoinositides is regulated by metal ions in vitro
    Authors:
    Damian Kolakowski, Joanna Kaminska, TeresaZoladek
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Biomembranes (rok: 2020, tom: 1862, strony: 183349), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamem.2020.183349 - link to the publication
  9. Yeast and other lower eukaryotic organisms for studies of Vps13 proteins in health and disease.
    Authors:
    RZEPNIKOWSKA W., FLIS K., MUÑOZ-BRACERAS S., MENEZES R., ESCALANTE R., ŻOŁĄDEK T.
    Academic press:
    Traffic (rok: 2017, tom: 18, strony: 711-719), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/tra.12523 - link to the publication
  1. Using yeast chorea-acanthocytosis model for drug screening
    Authors:
    SOCZEWKA P., TRIBOUILLARD-TANVIER D., DI RAGO J.-P., KAMIŃSKA J., ŻOŁĄDEK T.
    Conference:
    The 44th FEBS Congress, Kraków, Poland (rok: 2019, ), Wydawca: Wiley
    Data:
    konferencja 43652
    Status:
    Published
  2. Proceedings of the Ninth International Meeting on Neuroacanthocytosis Syndromes - RCN2 Encoding the Calcineurin Regulator Is a Suppressor of vps13 Mutations in a Yeast Chorea-acanthocytosis Model
    Authors:
    Piotr Soczewka, Marlena Grabiec, Joanna Kaminska, Teresa Zoladek
    Conference:
    The 9th International Meeting on Neuroacanthocytosis Syndromes (rok: 2018, ), Wydawca: Columbia University Libraries
    Data:
    konferencja 23-25.03.2018
    Status:
    Published
  3. Proceedings of the Ninth International Meeting on Neuroacanthocytosis Syndromes - Using yeast Vps13 Models of Chorea-acanthocytosis ti isolate Genetic and Chemical Suppressors
    Authors:
    Piotr Soczewka, Damian Kolakowski, Weronika Rzepnikowska, Marlena Grabiec, Krzysztof Flis, Joanna Kaminska, Teresa Zoladek
    Conference:
    The 9th International Meeting on Neuroacanthocytosis Syndromes (rok: 2018, ), Wydawca: Columbia University Libraries
    Data:
    konferencja 23-25.03.2018
    Status:
    Published
  4. Proceedings of the Ninth International Meeting on Neuroacanthocytosis Syndromes - Functional Link between Vps13 and Myo3, Type I Myosin
    Authors:
    Joanna Kamińska, Piotr Soczewka, Teresa Zoladek
    Conference:
    The 9th International Meeting on Neuroacanthocytosis Syndromes (rok: 2018, ), Wydawca: Columbia University Libraries
    Data:
    konferencja 23-25.03.2018
    Status:
    Published
  5. Proceedings of the Ninth International Meeting on Neuroacanthocytosis Syndromes - Bivalent Cation-dependent Phosphoinositide Bionding by the Chorein APT1 Domain
    Authors:
    Damian Kołakowski, Teresa Zoladek, Joanna Kamińska
    Conference:
    The 9th International Meeting on Neuroacanthocytosis Syndromes (rok: 2018, ), Wydawca: Columbia University Libraries
    Data:
    konferencja 23-25.03.2018
    Status:
    Published

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