Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Dynamics of gene expression control for bacterial restriction-modification systems using single-cell technology.

2015/19/B/NZ2/01835

Keywords:

restriction/modification transcription dynamics in time gene expression regulation single-cell technology

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ2_10: Biological systems analysis, modelling and simulation
  • NZ2_1: Molecular genetics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

UNIWERSYTET GDAŃSKI, Wydział Biologii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Iwona Mruk 

Number of co-investigators in the project: 3

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 767 600 PLN

Project start date (Y-m-d): 2016-08-05

Project end date (Y-m-d): 2021-01-04

Project duration:: 53 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zamrażarka niskotemperaturowa (-80 st. Celsjusza) (50 000 PLN)
  2. Wirówka laboratoryjna stołowa (9 000 PLN)
  3. Laptop Dell Latitude 3470.
  4. Laptop HP Pro Book 470 G4.
  5. spectrofotometr UV-Vis (33 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Transcriptome analyses of cells carrying the Type II Csp231I restriction-modification system reveal cross-talk between two unrelated transcription factors: C protein and the Rac prophage repressor
    Authors:
    Negri A. Jakalski M. Szczuka A. Pryszcz L. Mruk I.
    Academic press:
    Nucleic Acids Research (rok: 2019, tom: 47(18), strony: 9542-9556), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkz665. - link to the publication
  2. Regulator-dependent temporal dynamics of a restriction-modification system's gene expression upon entering new host cells: single-cell and population studies
    Authors:
    Alessandro Negri, Olesia Werbowy, Ewa Wons, Simon Dersch, Rebecca Hinrichs, Peter L. Graumann and Iwona Mruk
    Academic press:
    Nucleic Acids Reaserch (rok: 2021, tom: 49(7), strony: 3826-3840), Wydawca: Oxford Press
    Status:
    Published
    DOI:
    10.1093/nar/gkab183 - link to the publication

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