Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Structural characteristics of human ADPGK and GPD2 - enzymes involved in modified glucose metabolism of rapidly proliferating cells

2015/19/D/NZ1/02009

Keywords:

glycolysis ADPGK GPD2 Warburg Effect

Descriptors:

  • NZ1_4: Structural biology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Przemysław Grudnik 

Number of co-investigators in the project: 4

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 588 800 PLN

Project start date (Y-m-d): 2016-06-23

Project end date (Y-m-d): 2020-06-22

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. oprogramowanie EndNote.
  2. Komplet pipet automatycznych (3 000 PLN)
  3. zamrażarka laboratoryjna.
  4. Zestaw komputerowy (8 000 PLN)
  5. dysk twardy zewnętrzny.
  6. oprogramowanie Windows 10.

Information in the final report

  • Publication in academic press/journals (4)
  1. Crystal Structure of Kluyveromyces lactis Glucokinase (KlGlk1)
    Authors:
    Zak KM, Kalińska M, Wątor E, Kuśka K, Krutyhołowa R, Dubin G, Popowicz GM, Grudnik P.
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20(19), strony: 4821), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20194821 - link to the publication
  2. Structural Characterization of Glycerol Kinase from the Thermophilic Fungus Chaetomium thermophilum
    Authors:
    Piotr Wilk, Katarzyna Kuśka, Elżbieta Wątor, Piotr H Małecki, Klaudia Woś, Piotr Tokarz, Grzegorz Dubin, Przemysław Grudnik
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21(24), strony: 9570), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21249570 - link to the publication
  3. Crystal structure of ADP-dependent glucokinase from Methanocaldococcus jannaschii in complex with 5-iodotubercidin reveals phosphoryl transfer mechanism.
    Authors:
    Tokarz P, Wiśniewska M, Kamiński MM, Dubin G, Grudnik P.
    Academic press:
    Protein Science (rok: 2018, tom: 27, strony: 790-797), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/pro.3377 - link to the publication
  4. Structural basis for ADP-dependent glucokinase inhibition by 8-bromo-substituted adenosine nucleotide
    Authors:
    Grudnik P., Kamiński M.M., Rembacz K.P., Kuśka K., Madej M., Potempa J., Dawidowski M., Dubin G.
    Academic press:
    Journal of Biological Chemistry (rok: 2018, tom: 13, strony: 11088-11099), Wydawca: ASBMB Publications
    Status:
    Published
    DOI:
    10.1074/jbc.RA117.001562 - link to the publication

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