Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The use of insulin and glucose conjugates for the targeted therapy of breast cancer

2015/19/N/NZ5/00001

Keywords:

insulin glucose conjugates breast cancer targeted therapy

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ3_3: Apoptosis
  • NZ4_11: Metabolism

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Siddarth Agrawal 

Number of co-investigators in the project: 3

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 149 400 PLN

Project start date (Y-m-d): 2016-08-17

Project end date (Y-m-d): 2019-08-16

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mini spektrofotometr z licznikiem komórek (30 000 PLN)
  2. Pompa infuzyjna do podawania leków (3 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. 6-Shogaol enhances the anticancer effect of 5-fluorouracil, oxaliplatin, and irinotecan via increase of apoptosis and autophagy in colon cancer cells in hypoxic/aglycemic conditions
    Authors:
    Marta Woźniak, Sebastian Makuch, Kinga Winograd, Jerzy Wiśniewski, Piotr Ziółkowski, and Siddarth Agrawal
    Academic press:
    BMC ComplementaryMedicine and Therapies (rok: 2020, tom: 20, strony: 141), Wydawca: BMC - Springer Nature
    Status:
    Published
    DOI:
    10.1186%2Fs12906-020-02913-8 - link to the publication
  2. Clinical validation of nuclear factor kappa B expression in invasive breast cancer
    Authors:
    Anil Kumar Agrawal, Ewa Pielka, Artur Lipinski, Michal Jelen, Wojciech Kielan and Siddarth Agrawal
    Academic press:
    TUMOR BIOLOGY (rok: 2018, tom: 43101, strony: 1–10), Wydawca: Sage Journals
    Status:
    Published
    DOI:
    10.1177/1010428317750929 - link to the publication
  3. Insulin enhancement of the antitumor activity of chemotherapeutic agents in colorectal cancer is linked with downregulating PIK3CA and GRB2
    Authors:
    Siddarth Agrawal, Marta Woźniak, Mateusz Łuc, Sebastian Makuch, Ewa Pielka, Anil Kumar Agrawal, Joanna Wietrzyk, Joanna Banach, Andrzej Gamian, Monika Pizon & Piotr Ziółkowski
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: Article number: 16647), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-019-53145-x - link to the publication
  4. Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells
    Authors:
    Siddarth AgrawaL, Marta Wozniak, Mateusz Luc, Kinga Walaszek, Ewa Pielka, Wieslaw Szeja, Gabriela Pastuch-Gawolek, Andrzej Gamian and Piotr Ziolkowski
    Academic press:
    ONCOTARGET (rok: 2017, tom: 8, strony: 114173-114182), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.23170 - link to the publication

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