Projects funded by the NCN

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Information of the project and the call

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Functional characteristics and therapeutic potential of gain-of-function mutations in complement C2 protein.

2015/18/M/NZ6/00334

Keywords:

complement system convertase immunotherapy

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ6_2: Clinical immunology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marcin Okrój 

Number of co-investigators in the project: 5

Call: HARMONIA 7 - announced on 2015-06-15

Amount awarded: 1 291 200 PLN

Project start date (Y-m-d): 2016-06-13

Project end date (Y-m-d): 2021-06-12

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (2)
  1. Gain-of-Function Mutations R249C and S250C in Complement C2 Protein Increase C3 Deposition in the Presence of C-Reactive Protein
    Authors:
    Urban A, Kowalska D, Stasiłojć G, Kuźniewska A, Skrobińska A, Arjona E, Castellote Alonso E, Fenollosa Segarra MA, Jongerius I, Spaapen R, Satchell S, Thiel M, Ołdziej S, de Córdoba SR, Okrój M
    Academic press:
    Frontiers in Immunology (rok: 2021, tom: 12, strony: 724361), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fimmu.2021.724361 - link to the publication
  2. Gain-of-function mutation in complement C2 protein identified in a patient with aHUS.
    Authors:
    Urban A, Volokhina E, Felberg A, Stasiłojć G, Blom AM, Jongerius I, van den Heuvel L, Thiel M, Ołdziej S, Arjona E, de Córdoba SR, Okrój M.
    Academic press:
    Journal of Allergy and Clinical Immunology (rok: 2020, tom: 146, strony: 916-919.e11), Wydawca: Elsevier / American Academy of Allergy, Asthma & Immunology.
    Status:
    Published
    DOI:
    10.1016/j.jaci.2020.02.014 - link to the publication
  3. Genetic predisposition to infection in a case of atypical hemolytic uremic syndrome.
    Authors:
    Lambertus van den Heuvel, Kristian Riesbeck, Omaima El Tahir, Valentina Gracchi, Mariann Kremlitzka, Servaas A. Morré, A. Marceline van Furth, Birendra Singh, Marcin Okrój, Nicole van de Kar, Anna M. Blom, Elena Volokhina
    Academic press:
    Journal of Human Genetics (rok: 2018, tom: 69, strony: 93-96), Wydawca: Springer Nature Group
    Status:
    Published
    DOI:
    10.1038/s10038-017-0356-0 - link to the publication
  4. Mutations resulting in the formation of hyperactive complement convertases support cytocidal effect of anti-CD20 immunotherapeutics.
    Authors:
    Felberg A, Urban A, Borowska A, Stasiłojć G, Taszner M, Hellmann A, Blom AM, Okrój M.
    Academic press:
    Cancer Immunology Immunotherapy (rok: 2019, tom: 68, strony: 587-598), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00262-019-02304-0 - link to the publication
  5. Gain of function mutant of complement factor B K323E mimics pathogenic C3NeF autoantibodies in convertase assays.
    Authors:
    Urban Aleksandra, Borowska Anna, Felberg Anna, van den Heuvel Lambertus, Stasiłojć Grzegorz, Volokhina Elena, Okrój Marcin.
    Academic press:
    Autoimmunity (rok: 2018, tom: 51, strony: 18-24), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/08916934.2017.1423286 - link to the publication
  6. Nephritic Factors: An Overview of Classification, Diagnostic Tools and Clinical Associations.
    Authors:
    Corvillo F, Okrój M, Nozal P, Melgosa M, Sánchez-Corral P, López-Trascasa M.
    Academic press:
    Frontiers in Immunology (rok: 2019, tom: 10, strony: 886), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.00886 - link to the publication
  7. In silico designed gain-of-function variants of complement C2 support cytocidal activity of anticancer monoclonal antibodies.
    Authors:
    Aleksandra Urban, Alan Majeranowski, Grzegorz Stasiłojć, Patrycja Koszałka, Anna Felberg, Michał Taszner, Jan M Zaucha, Marcin Okrój
    Academic press:
    Cancers (rok: 2022, tom: -, strony: 0), Wydawca: MDPI
    Status:
    Submitted
    DOI:
    brak - link to the publication
  8. Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases.
    Authors:
    Michels MAHM, van de Kar NCAJ, Okrój M, Blom AM, van Kraaij SAW, Volokhina EB, van den Heuvel LPWJ
    Academic press:
    Frontiers in Immunology (rok: 2018, tom: 9, strony: 612), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fimmu.2018.00612 - link to the publication
  1. Clinics100Gain-of-function variants of complement C2 support cytoci-dal activity of anticancer monoclonal antibodies
    Authors:
    Aleksandra Urban, Alan Majeranowski, Grzegorz Stasiłojć, Patrycja Koszałka, Anna Felberg, Michał Taszner, Jan M. Zaucha, Marcin Okrój
    Conference:
    ICW – 2021 Virtual Workshop of the International Complement Society (rok: 2021, ), Wydawca: Molecular Immunology
    Data:
    konferencja 6-10 grudnia
    Status:
    Published
  2. Novel gain-of-function mutations R249C and S250C incomplement C2 protein in patients suffering from rare kidney diseases.
    Authors:
    Daria Kowalska, Aleksandra Urban, Alicja Kuźniewska, Anna Skrobińska, Santiago Rodriguez de Córdoba, Emilia Arjona, Marcin Okrój
    Conference:
    ICW – 2021 Virtual Workshop of the International Complement Society (rok: 2021, ), Wydawca: Molecular Immunology
    Data:
    konferencja 6-10 grudnia
    Status:
    Published

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