Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Cross-talk between the transport of mitochondrial proteins and cellular protein homeostasis

2015/18/A/NZ1/00025

Keywords:

mitochondra protein biogenesis protein transport protein degradation protein homeostasis

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_4: Ageing
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Agnieszka Chacińska 

Number of co-investigators in the project: 7

Call: MAESTRO 7 - announced on 2015-06-15

Amount awarded: 4 271 581 PLN

Project start date (Y-m-d): 2016-04-21

Project end date (Y-m-d): 2022-04-20

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Termomikser wraz z blokami grzewczymi do standardowych probówek 1,5 ml i 0,2 ml (19 986 PLN)
  2. Dezintegrator ultradźwiękowy np. Hielscher UP 50H (15 258 PLN)
  3. Armatka genowa (ang. Gene Gun).
  4. Wirówka z chłodzeniem (28 000 PLN)
  5. Wytrząsarka kołyskowa (4 195 PLN)
  6. Mikroskop fluorescencyjny (260 000 PLN)
  7. Pompa perystaltyczna (14 222 PLN)
  8. Zbiornik (dewar) na ciekły azot (20 000 PLN)
  9. mikroskop steroskopowy.
  10. Komputery (5 szt.) (40 840 PLN)
  11. Suchy blok grzejny np. termoblok z metalowym wsadem TB-941 U (3 900 PLN)
  12. Suszarka do żeli agarozowych np. Cleaver Scientific Gel dryer Maxi (11 500 PLN)
  13. Waga analityczna (5 280 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  1. Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins
    Authors:
    Nowicka U, Chroscicki P, Stroobants K, Sladowska M, Turek M, Uszczynska-Ratajczak B, Kundra R, Goral T, Perni M, Dobson CM, Vendruscolo M, Chacinska A.
    Academic press:
    eLife (rok: 2021, tom: 10, strony: 45318), Wydawca: eLife Sciences Publications Ltd
    Status:
    Published
    DOI:
    10.7554/eLife.65484 - link to the publication
  2. Protein trafficking at the crossroads to mitochondria.
    Authors:
    Wasilewski M., Chojnacka K., Chacinska A.
    Academic press:
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (rok: 2017, tom: 1864, strony: 125-137), Wydawca: ELSEVIER SCIENCE BV
    Status:
    Published
    DOI:
    10.019 - link to the publication
  3. Mitochondrial stress-dependent regulation of cellular protein synthesis
    Authors:
    Topf, U., Uszczynska-Ratajczak, B., & Chacinska, A.
    Academic press:
    Journal of Cell Science (rok: 2019, tom: 132(8), strony: jcs.226258), Wydawca: The Company of Biologists Ltd
    Status:
    Published
    DOI:
    10.1242/jcs.226258 - link to the publication
  4. Protein homeostasis is maintained by proteasomes containing PSMB9 induced by EEF1A2 upon mitochondrial stress
    Authors:
    Minji Kim, Lukasz Samluk, Tomasz Maciej Stępkowski, Ida Suppanz, Remigiusz Adam Serwa, Agata Kodroń, Bettina Warscheid, Agnieszka Chacinska
    Academic press:
    Nature Communications (rok: 2021, ), Wydawca: Nature Research
    Status:
    Submitted
    DOI:
    10.1101/2021.12.23.473808 - link to the publication
  5. Mitochondrial control of cellular protein homeostasis
    Authors:
    Mohanraj K., Nowicka U., Chacinska A.
    Academic press:
    Biochemical Journal (rok: 2020, tom: 477(16), strony: 3033–3054), Wydawca: Portland Press Limited on behalf of the Biochemical Society
    Status:
    Published
    DOI:
    10.1042/BCJ20190654 - link to the publication
  6. Mitochondrial protein import stress and signaling.
    Authors:
    Samluk Ł., Chrościcki P., Chacinska A.
    Academic press:
    Current Opinion in Physiology (rok: 2018, tom: 3, strony: 41–48.), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cophys.2018.02.010 - link to the publication
  7. Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system
    Authors:
    Bragoszewski, P., Turek, M., Chacinska, A.
    Academic press:
    Open Biology (rok: 2017, tom: 7:170007, strony: 45304), Wydawca: The Royal Society
    Status:
    Published
    DOI:
    10.1098/rsob.170007. - link to the publication
  8. Proteasome activity contributes to pro- survival response upon mild mitochondrial stress in Caenorhabditis elegans
    Authors:
    Sladowska M, Turek M, Kim MJ, Drabikowski K, Mussulini BHM, Mohanraj K, Serwa RA, Topf U, Chacinska A.
    Academic press:
    PLOS Biology (rok: 2021, tom: 19(7), strony: 11689), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pbio.3001302 - link to the publication

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