Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Developing of a new system for targeted anticancer therapy based on betulin derivetive and self-organizing polymeric nanovectors

2015/18/M/ST5/00060

Keywords:

controlled drug delivery systems biodegradable polymers cytostatic nanoparticles micelles

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials
  • ST5_12: Methods of nanomaterials/materials synthesis

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Śląski Uniwersytet Medyczny w Katowicach, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej w Sosnowcu

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Janusz Kasperczyk 

Number of co-investigators in the project: 10

Call: HARMONIA 7 - announced on 2015-06-15

Amount awarded: 1 396 800 PLN

Project start date (Y-m-d): 2016-04-13

Project end date (Y-m-d): 2020-04-12

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (1)
  1. NEW PHOSPHATE DERIVATIVES OF BETULIN AS ANTICANCER AGENTS: SYNTHESIS, CRYSTAL STRUCTURE, AND MOLECULAR DOCKING STUDY
    Authors:
    Elwira Chrobak, Monika Kadela-Tomanek, Ewa Bębenek, Krzysztof Marciniec, Joanna Wietrzyk,Justyna Trynda, Bartosz Pawełczak, Joachim Kusz, Janusz Kasperczyk, Ewa Chodurek, Piotr Paduszyński, Stanisław Boryczka
    Academic press:
    Bioorganic Chemistry (rok: 2019, tom: 87, strony: 613-628), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2019.03.060 - link to the publication
  2. Correlation between the composition of PLA-based folate targeted micelles and release of phosphonate derivative of betulin
    Authors:
    Katarzyna Jelonek, Bożena Kaczmarczyk, Arkadiusz Orchel, Ewa Chodurek, Marzena Jaworska – Kik, Piotr Paduszyński, Ewa Bębenek, Elwira Chrobak, Monika Musiał-Kulik, Aleksander Foryś, Stanisław Boryczka, Suming Li, Janusz Kasperczyk
    Academic press:
    Journal of Drug Delivery Science and Technology (rok: 2021, tom: 65, strony: Article 102717), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jddst.2021.102717 - link to the publication
  3. Anticancer activity of the acetylenic derivative of betulin phosphate involves induction of necrotic-like death in breast cancer cells in vitro
    Authors:
    Arkadiusz Orchel, Ewa Chodurek, Marzena Jaworska-Kik, Piotr Paduszyński, Anna Kaps, Elwira Chrobak, Ewa Bębenek, Stanisław Boryczka, Paulina Borkowska, Janusz Kasperczyk
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 615), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26030615 - link to the publication
  4. Bioresorbable filomicelles for targeted delivery of betulin derivative - in vitro study
    Authors:
    Katarzyna Jelonek, Janusz Kasperczyk, Suming L, Thi Hong Nhung Nguyen, Arkadiusz Orchel, Ewa Chodurek, Piotr Paduszyński, Marzena Jaworska-Kik, ElwiraChrobak, Ewa Bębenek, Stanisław Boryczka, MagdalenaJarosz-Biej, Ryszard Smolarczyk, Aleksander Foryś
    Academic press:
    International Journal of Pharmaceutics (rok: 2019, tom: 557, strony: 43-52), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2018.12.033 - link to the publication
  1. SINGLE AND MULTIDRUG FILOMICELLES AS ANTICANCER DRUG DELIVERY SYSTEM
    Authors:
    KATARZYNA JELONEK, JANUSZ KASPERCZYK, SUMING LI, BOŻENA KACZMARCZYK, ARKADIUSZ ORCHEL, MONIKA MUSIAŁ-KULIK
    Conference:
    Biomaterials in Medicine and Veterinary Medicine (rok: 2016, ), Wydawca: Scientific Publishing House AKAPIT, Wydawnictwo Naukowe AKAPIT (Inżynieria Biomateriałów)
    Data:
    konferencja 13-16 październik
    Status:
    Published
    DOI:
    link to the publication

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