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Changes in human skin cells mitochondria carrying mutations causing Huntington's diseasae

2015/17/N/NZ2/04267

Keywords:

Huntington's disease neurodegeneration mitochondria mtDNA

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ2_11: Genetic epidemiology

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Gdański, Wydział Biologii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Paulina Jędrak 

Number of co-investigators in the project: 2

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 99 600 PLN

Project start date (Y-m-d): 2016-03-03

Project end date (Y-m-d): 2018-04-02

Project duration:: 25 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (3)
  1. Mitochondrial alterations accompanied by oxidative stress conditions in skin fibroblasts of Huntington's disease patients
    Authors:
    Paulina Jedrak, Pawel Mozolewski, Grzegorz Wegrzyn, Mariusz R Wieckowski
    Academic press:
    Metabolic Brain Disease (rok: 2018, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11011-018-0308-1 - link to the publication
  2. Characterization of conditions and determination of practical tips for mtDNA level estimation in various human cells
    Authors:
    Paulina Jędrak, Natalia Sowa, Sylwia Barańska, Grzegorz Węgrzyn
    Academic press:
    Acta Biochimica Polonica (rok: 2017, tom: 64, strony: 699–704), Wydawca: Polish Biochemical Society and of the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2017_2303 - link to the publication
  3. Mitochondria and reactive oxygen species in aging and age-related diseases
    Authors:
    Carlotta Giorgi, Saverio Marchi, Ines C.M. Simoes, Ziyu Ren, Giampaolo Morciano, Maria Sole Perrone, Paulina Patalas-Krawczyk, Sabine Borchard, Paulina Jedrak, Karolina Pierzynowska, Jedrzej Szymański, David Q. Wang, Piero Portincasa, Grzegorz Wegrzyn, Hans Zischka, Pawel Dobrzyn, Massimo Bonora, Jerzy Duszyński, Alessandro Rimessi, Agnieszka Karkucinska-Wieckowska, Agnieszka Dobrzyn, Gyorgy Szabadkai, Barbara Zavan, Paulo J Oliveira, Vilma A Sardão, Paolo Pinton, Mariusz Wieckowski
    Academic press:
    International review of cell and molecular biology (rok: 2018, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/bs.ircmb.2018.05.006 - link to the publication
  1. Cell cycle and oxidative stress in Huntington disease dermal fibroblasts
    Authors:
    Paulina Jędrak, Paweł Mozolewski, Grzegorz Węgrzyn, Mariusz R Więckowski
    Conference:
    42nd FEBS Congress From molecules to cells and back (rok: 2017, ), Wydawca: The FEBS Journal
    Data:
    konferencja 10-14 września
    Status:
    Published
  2. Alterations in mitochondrial function in huntington's disease fibroblasts
    Authors:
    Paulina Jędrak, Mariusz R. Więckowski, Grzegorz Węgrzyn
    Conference:
    9th European Huntington's Disease Network Plenary Meeting (EHDN 2016) (rok: 2016, ), Wydawca: Journal of Neurology Neurosurgery & Psychiatry
    Data:
    konferencja 16-18 września 2016
    Status:
    Published
    DOI:
    link to the publication
  3. Practical guidance on the measurement of mtDNA levels in blood and fibroblasts
    Authors:
    Paulina Jędrak, Natalia Sowa, Sylwia Barańska, Grzegorz Węgrzyn
    Conference:
    7th World Congress on Targeting Mitochondria (rok: 2016, ), Wydawca: Journal of World Mitochondria Society
    Data:
    konferencja 24-26 października 2016
    Status:
    Published

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