Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The functional role of astroglial CD44 i seizure-induced aberrant synaptic plasticity.

2015/17/B/NZ4/02540

Keywords:

CD44 astrocyty drgawki plastyczność synaptyczna padaczka

Descriptors:

  • NZ4_10: Neuroimaging and computational neuroscience

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Joanna Dzwonek 

Number of co-investigators in the project: 5

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 908 400 PLN

Project start date (Y-m-d): 2016-02-22

Project end date (Y-m-d): 2020-02-21

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. aparatu do transfekcji komórek metodą nukleofekcji - Nukleofektor.
  2. komputer przenosny (6 000 PLN)
  3. inkubator do hodowli komórkowych z kontrolowanym dostepem CO2/O2 (60 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. The interplay of seizures-induced axonal sprouting and transcription-dependent Bdnf repositioning in the model of temporal lobe epilepsy
    Authors:
    Anna Skupien-Jaroszek1☯, Agnieszka Walczak1☯, Iwona Czaban1 , Katarzyna Karolina Pels1 , Andrzej Antoni SzczepankiewiczID1 , Katarzyna Krawczyk1 , Błażej Ruszczycki1 , Grzegorz Marek Wilczynski1†, Joanna Dzwonek1 *, Adriana MagalskaID1,2*
    Academic press:
    PLOS ONE (rok: 2021, tom: 16(6), strony: 45309), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0239111 - link to the publication
  2. Cleavage of Hyaluronan and CD44 Adhesion Molecule Regulate Astrocyte Morphology via Rac1 Signalling
    Authors:
    Anna Konopka, Andre Zeug, Anna Skupien, Beata Kaza, Franziska Mueller, Agnieszka Chwedorowicz, Evgeni Ponimaskin, Grzegorz M. Wilczynski, Joanna Dzwonek
    Academic press:
    Plos One (rok: 2016, tom: 11(5), strony: 45305), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0155053 - link to the publication
  3. MMP-9 Signaling Pathways That Engage Rho GTPases in Brain Plasticity
    Authors:
    Izabela Figiel † , Patrycja K. Kruk † , Monika Zar ˛eba-Kozioł, Paulina Rybak, Monika Bijata , Jakub Wlodarczyk and Joanna Dzwonek
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 166-188), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10010166. - link to the publication
  4. Astrocytic CD44 Deficiency Reduces the Severity of Kainate-Induced Epilepsy
    Authors:
    Patrycja K. Kruk 1 , Karolina Nader 2 , Anna Skupien-Jaroszek 1 , Tomasz Wójtowicz 1 , Anna Buszka 1 , Gabriela Olech-Kocha ´nczyk 3 , Grzegorz M. Wilczynski 3,†, Remigiusz Worch 1 , Katarzyna Kalita 2 , Jakub Włodarczyk 1 and Joanna Dzwonek 1,*
    Academic press:
    Cells (rok: 2023, tom: 121483, strony: 45313), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells12111483 - link to the publication

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