Projects funded by the NCN
Genotoxicity of antitumor compound 3-bromopyruvate in the yeast Saccharomyces cerevisiae.
2015/17/D/NZ2/01985
Keywords:
3-bromopyruvate yeast DNA repair cell cycle checkpoints response to DNA damage
Descriptors:
- NZ2_1: Molecular genetics
Panel:
NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology
Host institution :
Uniwersytet Wrocławski, Wydział Nauk Biologicznych
woj. dolnośląskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 3
Call: SONATA 9 - announced on 2015-03-16
Amount awarded: 450 000 PLN
Project start date (Y-m-d): 2016-03-07
Project end date (Y-m-d): 2021-09-06
Project duration:: 66 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Laptop wraz z oprogramowaniem MS Office oraz OS Windows a także z dyskiem zewnętrznym (3 500 PLN)
- Zestaw do elektroforezy żelowej białek z wyposażeniem i modułem do transferu mokrego oraz z zasilaczem (13 000 PLN)
- Mikroskop optyczny z możliwością obserwacji w kontraście fazowym wraz z kamerą (40 000 PLN)
- Termoblok z wytrząsaniem (13 000 PLN)
- Urządzenie archiwizujące - zestaw komputerowy.
Information in the final report
- Publication in academic press/journals (3)
- Glutathione may have implications in the design of 3-bromopyruvate treatment protocols for both fungal and algal infections as well as multiple myelomaAuthors:Niedźwiecka K., Dyląg M., Augustyniak D., Majkowska-Skrobek G., Cal-Bąkowska M., Ko YH., Pedersen PL., Goffeau A., Ułaszewski S.Academic press:Oncotarget (rok: 2016, tom: 40, strony: 65614-65626), Wydawca: OncotargetStatus:PublishedDOI:10.18632/oncotarget.11592 - link to the publication
- Mitochondrial Function Are Disturbed in the Presence of the Anticancer Drug, 3-BromopyruvateAuthors:Magdalena Cal, Irwin Matyjaszczyk, Karolina Filik, Rafał Ogórek, Young Ko and Stanisław UłaszewskiAcademic press:International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 6640), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms22126640 - link to the publication
- The Anticancer Drug 3-Bromopyruvate Induces DNA Damage Potentially Through Reactive Oxygen Species in Yeast and in Human Cancer CellsAuthors:Magdalena Cal, Irwin Matyjaszczyk, Ireneusz Litwin, Daria Augustyniak, Rafał Ogórek, Young Ko, Stanisław UłaszewskiAcademic press:Cells (rok: 2020, tom: 9, strony: 1161), Wydawca: MDPIStatus:PublishedDOI:10.3390/cells9051161 - link to the publication