Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of transcriptional repressors KRAB-ZNFs (Kruppel-associated box - zinc finger proteins) in modulating epigenetic profile of cancer cells

2015/17/B/NZ2/03689

Keywords:

epigenetics cancer TCGA epigenetic repression cancer trascriptomics and epigenomics

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ5_3: Pathogenesis of human diseases
  • NZ3_1: Cell biology

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Urszula Oleksiewicz 

Number of co-investigators in the project: 5

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 092 800 PLN

Project start date (Y-m-d): 2016-01-19

Project end date (Y-m-d): 2023-01-18

Project duration:: 84 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer (8 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  1. Epigenetics: the guardian of pluripotency and differentiation
    Authors:
    Marta GŁADYCH, Aleksandra NIJAK, Paula LOTA, Urszula OLEKSIEWICZ
    Academic press:
    Turkish Journal of Biology (rok: 2016, tom: 40, strony: 1018-1032), Wydawca: Scientific and Technological Research Council of Turkey
    Status:
    Published
    DOI:
    10.3906/biy-1509-30 - link to the publication
  2. KRAB-ZFPs and cancer stem cells identity
    Authors:
    Anna Olechnowicz, Urszula Oleksiewicz, Marta Machnik
    Academic press:
    Genes & Diseases (rok: 2022, tom: In press, strony: In press), Wydawca: ScienceDirect
    Status:
    Published
    DOI:
    10.1016/j.gendis.2022.03.013 - link to the publication
  3. Causes, effects, and clinical implications of perturbed patterns within the cancer epigenome
    Authors:
    Urszula Oleksiewicz, Marta Machnik
    Academic press:
    Seminars in Cancer Biology (rok: 2020, tom: n.d., strony: n.d.), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.semcancer.2020.12.014. - link to the publication
  4. Dynamic Signatures of the Epigenome: Friend or Foe?
    Authors:
    Marta Machnik, Urszula Oleksiewicz
    Academic press:
    Cells (rok: 2020, tom: 9(3), strony: 653), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9030653 - link to the publication
  5. The expression signature of cancer-associated KRAB-ZNF factors identified in TCGA pan-cancer transcriptomic data.
    Authors:
    Machnik M, Cylwa R, Kiełczewski K, Biecek P, Liloglou T, Mackiewicz A, Oleksiewicz U.
    Academic press:
    Molecular Oncology (rok: 2019, tom: 13(4), strony: 701-724), Wydawca: FEBS Press
    Status:
    Published
    DOI:
    10.1002/1878-0261.12407 - link to the publication
  6. KRAB-ZFP Transcriptional Regulators Acting as Oncogenes and Tumor Suppressors: An Overview
    Authors:
    Joanna Sobocińska, Sara Molenda, Marta Machnik, Urszula Oleksiewicz
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(4), strony: 2212), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22042212 - link to the publication
  7. KRAB ZNF explorer-the online tool for the exploration of the transcriptomic profiles of KRAB-ZNF factors in The Cancer Genome Atlas.
    Authors:
    Cylwa R, Kiełczewski K, Machnik M, Oleksiewicz U, Biecek P.
    Academic press:
    Bioinformatics (rok: 2020, tom: 36(3), strony: 980-981), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/bioinformatics/btz624. - link to the publication
  8. Zinc Finger Proteins in Head and Neck Squamous Cell Carcinomas: ZNF540 May Serve as a Biomarker
    Authors:
    Sobocińska, J.; Nowakowska, J.; Molenda, S.; Olechnowicz, A.; Guglas, K.; Kozłowska-Masłoń, J.; Kazimierczak, U.; Machnik, M.; Oleksiewicz, U.; Teresiak, A.; Lamperska, K.; Kolenda, T.
    Academic press:
    Current Oncology (rok: 2022, tom: 29, strony: 9896-9915), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/curroncol29120779 - link to the publication

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