Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Interactions between commonly used antiarrhythmic and antiepileptic drugs in the model of generalized tonic-clonic convulsions - theoretical basis of the treatment in patients with epilepsy and arrhythmias

2015/17/B/NZ4/01763

Keywords:

antiepileptic drugs antiarrhythmic drugs interactions safety profile

Descriptors:

  • NZ4_4: Pathophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Lekarski

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Kinga Borowicz - Reutt 

Number of co-investigators in the project: 3

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 605 920 PLN

Project start date (Y-m-d): 2016-03-17

Project end date (Y-m-d): 2020-03-16

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Urządzenie do badania biernego unikania u myszy (160 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model.
    Authors:
    Banach M, Popławska M, Borowicz-Reutt KK.
    Academic press:
    Pharmacological Reports (rok: 2017, tom: 69(6), strony: 1173-1177), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2017.05.005 - link to the publication
  2. Interactions of mexiletine with novel antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis.
    Authors:
    Dorota Wróblewska, Monika Rudkowska,Monika Banach, Kinga K Borowicz-Reutt
    Academic press:
    Neurochem Res (rok: 2018, tom: 43 (10), strony: 1887-1896), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-018-2606-8 - link to the publication
  3. Influence of propafenone on the anticonvulsant activity of various novel antiepileptic drugs in the mouse maximal electroshock model
    Authors:
    Kinga K. Borowicz-Reutt, Monika Popławska, Monika Banach, Dorota Wróblewska
    Academic press:
    Pharmacological Reports (rok: 2017, tom: 70 (3), strony: 481-487), Wydawca: Elsevier
    Status:
    Published
    DOI:
    0.1016/j.pharep.2017.11.014 - link to the publication

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