Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Dissecting pathomechanisms of idiopathic form of Parkinson's Disease using induced pluripotent stem cells technology

2015/17/B/NZ5/00294

Keywords:

Parkinson's Disease induced pluripotent stem cells dopaminergic neurons microglia mitochondria

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_1: Etiology of human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marcin Majka 

Number of co-investigators in the project: 6

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 515 600 PLN

Project start date (Y-m-d): 2016-02-16

Project end date (Y-m-d): 2020-05-15

Project duration:: 51 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator (40 000 PLN)
  2. Stolik zmotoryzowany do mikroskopu (45 000 PLN)
  3. Komora filtracyjna CR-670 z mikroskopem stereoskopowym Z-140 (25 000 PLN)
  4. Płatkarka do lodu (15 000 PLN)
  5. Rotarod (65 000 PLN)
  6. Urzadzenie sterujace pracą zmotoryzowanych modułów (25 000 PLN)
  7. Mikroskop odwrócony (30 000 PLN)
  8. Zmotoryzowany fluorescencyjny mikroskop prosty.
  9. Cyfrowy mikroskop odwrócony.
  10. Nablatowa komora laminarna.
  11. Zmotoryzowany rewolwerowy zmieniacz filtrów (25 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (2)
  1. Highly Effective Protocol for Differentiation of Induced Pluripotent Stem Cells (iPS) into Melanin-Producing Cells
    Authors:
    Maciej Sułkowski, Marta Kot, Bogna Badyra, Anna Paluszkiewicz, Przemysław M. Płonka, Michał Sarna, Dominika Michalczyk-Wetula, Fabio A. Zucca,Luigi Zecca, Marcin Majka
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 12787), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222312787 - link to the publication
  2. Use of 3D Organoids as a Model to Study Idiopathic Form of Parkinson's Disease
    Authors:
    Paula Chlebanowska , Anna Tejchman, Maciej Sułkowski, Klaudia Skrzypek, Marcin Majka
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 694), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21030694 - link to the publication
  3. Carbon fibers as a new type of scaffold for 3D organoid modeling to study midbrain-associated neurodegenerative diseases
    Authors:
    Anna Tejchman, Agnieszka Znój, Paula Clebanowska, Aneta Frączek-Szczypta and Marcin Majka
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 5959), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21175959 - link to the publication
  4. Origin of the induced pluripotent stem cells affects their differentiation into dopaminergic neurons
    Authors:
    Paula Chlebanowska, Maciej Sułkowski, Klaudia Skrzypek, Anna Tejchman and Marcin Majka
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 5705), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21165705 - link to the publication
  5. Introduction of Exogenous HSV-TK Suicide Gene Increases Safety of Keratinocyte-Derived Induced Pluripotent Stem Cells by Providing Genetic Emergency Exit" Switch
    Authors:
    Maciej Sułkowski, Paweł Konieczny, Paula Chlebanowska and Marcin Majka
    Academic press:
    International Journal o f Molecular Sciences (rok: 2018, tom: 19, strony: 197), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19010197 - link to the publication
  1. Targeting key signaling factors as a way to control microglial activation and induction of neuroinflammation
    Authors:
    Bogna Badyra, Anna Tejchman, Marcin Majka
    Conference:
    44th FEBS Congress, From Molecules to Living Systems (rok: 2019, ), Wydawca: FEBS OPEN BIO
    Data:
    konferencja 43652
    Status:
    Published
    DOI:
    link to the publication
  2. Comparing neuronal differentiation of human induced pluripotent stem (iPS) cells from different tissue of single donor
    Authors:
    Paula Chlebanowska, Maciej Sulkowski, Anna Tejchman, Marcin Majka
    Conference:
    44th FEBS Congress, From Molecules to Living Systems (rok: 2019, ), Wydawca: FEBS OPEN BIO
    Data:
    konferencja 43652
    Status:
    Published
    DOI:
    link to the publication

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