Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Identification of new breast cancer susceptibility genes by whole-exome sequencing in the genetically homogeneous Polish population

2015/17/B/NZ5/02543

Keywords:

breast cancer aethiology genetic susceptibility genes mutations high risk

Descriptors:

  • NZ5_1: Etiology of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Farmacji, Biotechnologii Medycznej i Medycyny Laboratoryjnej

woj. zachodniopomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Cezary Cybulski 

Number of co-investigators in the project: 6

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 999 075 PLN

Project start date (Y-m-d): 2016-04-12

Project end date (Y-m-d): 2022-04-11

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Allelic modification of breast cancer risk in women with an NBN mutation
    Authors:
    Rusak B, Kluźniak W, Wokołorczyk D, Stempa K, Kashyap A, Rudnicka H, Gronwald J, Huzarski T, Dębniak T, Jakubowska A, Szwiec M, Akbari MR, Narod SA, Lubiński J, Cybulski C; Polish Hereditary Breast Cancer Consortium
    Academic press:
    Breast Cancer Res Treat. (rok: 2019, tom: 178(2), strony: 427-431), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s10549-019-05391 - link to the publication
  2. Common Variant in ALDH2 Modifies the Risk of Breast Cancer Among Carriers of the p.K3326* Variant in BRCA2
    Authors:
    Wojciech Kluźniak, Agata Szymiczek, Amelie Rodrigue, Dominika Wokołorczyk, Bogna Rusak, Klaudia Stempa, Tomasz Huzarski, Jacek Gronwald, Jan Lubiński, Neda Zamani, Shiyu Zhang, Jean-Yves Masson, Steven A Narod, Polish Hereditary Breast Cancer Consortium, Cezary Cybulski, Mohammad R Akbari
    Academic press:
    JCO Precis Oncol. (rok: 2022, tom: opubikowane online Apr;6:e2100, strony: 45298), Wydawca: ASCO (American Society of Clinical Oncology)
    Status:
    Published
    DOI:
    10.1200/PO.21.00450 - link to the publication
  3. The spectrum of mutations predisposing to familial breast cancer in Poland.
    Authors:
    Cybulski Cezary, Kluźniak Wojciech, Huzarski Tomasz, Wokołorczyk Dominika, Kashyap Aniruddh, Rusak Bogna, Stempa Klaudia, Gronwald Jacek, Szymiczek Agata, Bagherzedeh Maryam, Jakubowska Anna, Dębniak Tadeusz, Lener Marcin, Rudnicka Helena, Szwiec Marek, Jarkiewicz-Tretyn Joanna, Stawicka Małgorzata, Domagała Paweł, Narod Steven A., Lubiński Jan, Akbari Mohammad R.
    Academic press:
    International Journal of Cancer (rok: 2019, tom: vol. 145, nr 12, strony: s. 3311-3320), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/ijc.32492. - link to the publication
  4. Inherited variants in BLM and the risk and clinical characteristics of breast cancer
    Authors:
    Kluźniak Wojciech, Wokołorczyk Dominika, Rusak Bogna, Huzarski Tomasz, Kashyap Aniruddh, Stempa Klaudia, Rudnicka Helena, Jakubowska Anna, Szwiec Marek, Morawska Sylwia, Gliniewicz Katarzyna, Mordak Karina, Stawicka Małgorzata, Jarkiewicz-Tretyn Joanna, Cechowska Magdalena, Domagała Paweł, Dębniak Tadeusz, Lener Marcin, Gronwald Jacek, Lubiński Jan, Narod Steven A., Akbari Mohammad R., Cybulski Cezary.
    Academic press:
    Cancers (rok: 2019, tom: vol. 11, nr 10, strony: art. 1548, 11 stron), Wydawca: MDPI, Basel, Switzerland.
    Status:
    Published
    DOI:
    10.3390/cancers11101548 - link to the publication
  5. Inherited variants in XRCC2 and the risk of breast cancer
    Authors:
    Kluźniak Wojciech, Wokołorczyk Dominika, Rusak Bogna, Huzarski Tomasz, Gronwald Jacek, Stempa Klaudia, Rudnicka Helena, Kashyap Aniruddh, Dębniak Tadeusz, Jakubowska Anna, Lener Marcin, Szwiec Marek, Tomiczek-Szwiec Joanna, Jarkiewicz-Tretyn Joanna, Cechowska Magdalena, Domagała Paweł, Szymiczek Agata, Bagherzedeh Maryam, Lubiński Jan, Narod Steven A., Akbari Mohammad R., Cybulski Cezary.
    Academic press:
    Breast Cancer Res Treat. (rok: 2019, tom: vol. 178, nr 3, strony: s. 657-663), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s10549-019-05415-5 - link to the publication
  6. Prevalence of Recurrent Mutations Predisposing to Breast Cancer in Early-Onset Breast Cancer Patients from Poland
    Authors:
    Rogoża-Janiszewska E, Malińska K, Cybulski C, Jakubowska A, Gronwald J, Huzarski T, Lener M, Górski B, Kluźniak W, Rudnicka H, Akbari MR, Kashyap A, Narod SA, Lubiński J, Dębniak T, On Behalf Of The Polish Hereditary Breast Cancer Consortium
    Academic press:
    Cancers (rok: 2020, tom: 12(8):2321, strony: 10 stron), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/cancers12082321. - link to the publication

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