Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Porphyromonas gingivalis protein and its homologs from other periodontopathogens - a novel group of bacterial virulence factors

2015/17/B/NZ6/01969

Keywords:

Porphyromonas gingivalis periodontal diseases HmuY protein virulence Toll-like receptors heme immune response macrophages

Descriptors:

  • NZ6_4: Bacteriology
  • NZ1_10: Microbiology
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Teresa Olczak 

Number of co-investigators in the project: 8

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 898 000 PLN

Project start date (Y-m-d): 2016-02-16

Project end date (Y-m-d): 2019-02-15

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zestaw do rozdziału makrocząsteczek FPLC (160 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Apoptosis transcriptional profile induced by Porphyromonas gingivalis HmuY
    Authors:
    Carvalho-Filho PC, de Moura-Costa LF, Pimentel ACM, Lopes M, Freitas SA, Miranda PM, Costa R, Figueiredo CA, Meyer R, Gomes-Filho IS, Olczak T, Xavier MT, Trindade SC
    Academic press:
    Mediators of Inflammation (rok: 2019, tom: 2019:6758159, strony: 45299), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2019/6758159 - link to the publication
  2. Prevotella intermedia produces two proteins homologous to Porphyromonas gingivalis HmuY but with different heme coordination mode
    Authors:
    Bielecki M., Antonyuk S., Strange R.W., Sieminska K., Smalley J.W., Mackiewicz P., Smiga M., Cowan M.,Capper M.J., Slezak P., Olczak M., Olczak T.
    Academic press:
    Biochemical Journal (rok: 2020, tom: 477, strony: 381-405), Wydawca: Portland Press
    Status:
    Published
    DOI:
    10.1042/BCJ20190607 - link to the publication
  3. Tannerella forsythia Tfo belongs to Porphyromonas gingivalis HmuY-like family of proteins but differs in heme-binding properties
    Authors:
    Bielecki M, Antonyuk S, Strange RW, Smalley JW, Mackiewicz P, Śmiga M, Stępień P, Olczak M, Olczak T
    Academic press:
    Bioscience Reports (rok: 2018, tom: 38(5), strony: BSR20181325), Wydawca: Portland Press
    Status:
    Published
    DOI:
    10.1042/BSR20181325 - link to the publication
  4. Role of Porphyromonas gingivalis HmuY in immunopathogenesis of chronic periodontitis.
    Authors:
    Carvalho-Filho P.C., Gomes-Filho I.S., Meyer R., Olczak T., Xavier M.T., Trindade S.C.
    Academic press:
    Mediators of Inflammation (rok: 2016, tom: 2016:7465852, strony: 45300), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2016/7465852 - link to the publication
  5. Immune response of macrophages induced by Porphyromonas gingivalis requires HmuY protein.
    Authors:
    Gmiterek A., Kłopot A., Wójtowicz H., Trindade S.C., Olczak M., Olczak T.
    Academic press:
    Immunobiology (rok: 2016, tom: 221, strony: 1382-1394), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.imbio.2016.07.007 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy