Projects funded by the NCN
Quenched Activity Based Probe as a tool in imagining of active osteoclast's cathepsin K
2015/17/D/ST5/01347
Keywords:
cathepsin K quenched activity based probe specificity
Descriptors:
- ST5_16:
- ST5_23:
Panel:
ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution :
Politechnika Wrocławska, Wydział Chemiczny
woj. dolnośląskie
Principal investigator (from the host institution):
dr Paulina Kasperkiewicz-Wasilewska
Number of co-investigators in the project: 2
Call: SONATA 9 - announced on 2015-03-16
Amount awarded: 656 660 PLN
Project start date (Y-m-d): 2016-09-01
Project end date (Y-m-d): 2019-08-31
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- liofilizator (82 965 PLN)
- Mikroskop fluorescencyjny (125 000 PLN)
- Laptop (4 500 PLN)
Information in the final report
- Publication in academic press/journals (2)
- A protocol to visualize active cathepsin K in osteoclasts with quenched-fluorescent activity-based probeAuthors:Aleksandra Korba, Izabela Ciastoń, Joanna Kozieł, Paulina KasperkiewiczAcademic press:STAR METHODS (rok: 2023, ), Wydawca: CellStatus:SubmittedDOI:brak - link to the publication
- IInvestigation of osteoclast cathepsin K activity in osteoclastogenesis and bone loss using a set of chemical reagentsAuthors:Tomasz Janiszewski, Sonia Kołt, Izabela Ciastoń, Matej Vizovisek, Marcin Poręba, Boris Turk, Marcin Drąg, Joanna Kozieł, Paulina KasperkiewiczAcademic press:Cell Chemical Biology (rok: 2023, tom: 30, strony: 159-174.e8), Wydawca: CellStatus:PublishedDOI:10.1016/j.chembiol.2023.01.001 - link to the publication