Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The impact of the integrin alpha-2 beta-1 on collagen metabolism regulation in atrial fibroblasts.

2015/17/B/NZ5/01382

Keywords:

integrin collagen atrial human fibroblasts mechanical stress

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jacek Drobnik 

Number of co-investigators in the project: 5

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 898 800 PLN

Project start date (Y-m-d): 2016-02-16

Project end date (Y-m-d): 2020-10-15

Project duration:: 56 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Termocykler Real Time PCR; Light Cycler 96; Roche Diagnostics Polska sp. z o.o. (136 000 PLN)
  2. Spektrofotometr NanoDrop 2000 EU; Thermo Scientific Inc. (46 000 PLN)
  3. ADAM-MC - automatyczny licznik komórek wraz z zestawem startowym na 400 oznaczeń (38 500 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (4)
  1. Stiff substrates inhibit collagen accumulation via integrin α2β1, FAK and Src kinases in human atrial fibroblast and myofibroblast cultures derived from patients with aortal stenosis.
    Authors:
    Gałdyszyńska M., Zwoliński R., Piera L., Szymański J., Jaszewski R., Drobnik J.
    Academic press:
    Biomedicine & Pharmacotherapy   (rok: 2023, tom: 159, strony: 114289), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2023.114289 - link to the publication
  2. The stiffness-controlled release of interleukin-6 by cardiac fibroblasts is dependent on integrin α2β1
    Authors:
    Małgorzata Gałdyszyńska, Justyna Bobrowska, Małgorzata Lekka, Paulina Radwańska, Lucyna Piera, Jacek Szymański, Jacek Drobnik
    Academic press:
    Journal of Cellular and Molecular Medicine (rok: 2020, tom: nie dotyczy, strony: 45301), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1111/jcmm.15974 - link to the publication
  3. The Stiffness of Cardiac Fibroblast Substrates Exerts a Regulatory Influence on Collagen Metabolism via α2β1 Integrin, FAK and Src Kinases.
    Authors:
    Gałdyszyńska M, Radwańska P, Szymański J, Drobnik J.
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10123506. - link to the publication
  1. RELEASE OF INTERLEUKIN-6 IS DEPENDENT ON a2b1 INTEGRIN
    Authors:
    M. GALDYSZYNSKA, P. RADWANSKA , J. DROBNIK
    Conference:
    XXVIII Congress of the Polish Physiological Society (rok: 2021, ), Wydawca: Polish Physiological Society
    Data:
    konferencja 2021.09.15-17
    Status:
    Published
  2. Regulacyjny wpływ twardości podłoża oraz integryny α2β1, kinazy Src i FAK na akumulację kolagenu w hodowlach miofibroblastów z przedsionków serca
    Authors:
    Małgorzata Galdyszyńska, Radosław Zwoliński, Lucyna Piera, Jacek Szymański, Ryszard Jaszewski, Jacek Drobnik
    Conference:
    XXVI Sympozjum Sekcji Kardiologii Eksperymentalnej Polskiego Towarzystwa Kardiologicznego (rok: 2022, ), Wydawca: Polish Academy of Sciences Krakow Branch, Jagiellonian University Medical College
    Data:
    konferencja 27-29 październik 2022
    Status:
    Published
  3. Collagen metabolism within a cardiac fibroblasts culture is dependent on physical properties of the cell environment
    Authors:
    Małgorzata Gałdyszyńska, Jacek Drobnik
    Conference:
    Matrix Biology Europe (rok: 2018, ), Wydawca: WILEY
    Data:
    konferencja 2018-07-21 - 2018-07-24
    Status:
    Published
  4. Stiff substrate inhibits collagen accumulation via integrin α2β1, FAK and Src kinases in human cardiac fibroblasts derived from patients with aortal stenosis
    Authors:
    Małgorzata Gałdyszyńska, Radosław Zwoliński, Lucyna Piera, Jacek Szymański, Ryszard Jaszewski, Jacek Drobnik
    Conference:
    Matrix Biology Europe (rok: 2022, ), Wydawca: Societa Italiano per lo Studio del Connecttivo
    Data:
    konferencja 28-30 wrzesień 2022
    Status:
    Published

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