Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Effect of alpha-1 antitrypsin on neutrophil phenotypes: new regulatory mechanisms of chronic inflammation in the respiratory tract.

2015/17/B/NZ5/01370

Keywords:

neutrophils alpha-1 antitrypsin conformation COPD AAT deficiency cytokines

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_9: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Gruźlicy i Chorób Płuc

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Sabina Janciauskiene-Wallmark 

Number of co-investigators in the project: 4

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 202 325 PLN

Project start date (Y-m-d): 2016-03-23

Project end date (Y-m-d): 2022-03-22

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. Plasma Acute Phase Proteins as Predictors of Chronic Lung Allograft Dysfunction in Lung Transplant Recipients
    Authors:
    Sabina Janciauskiene,Pierre-Joseph Royer,Jan Fuge,Sabine Wrenger,Joanna Chorostowska- Wynimko,Christine Falk,Tobias Welte,Martine Reynaud-Gaubert,Antoine Roux,Adrien Tissot,Antoine Magnan
    Academic press:
    Journal of Inflammation Research (rok: 2020, tom: 13, strony: 1021-1028), Wydawca: Dovepress
    Status:
    Published
    DOI:
    10.2147/JIR.S272662 - link to the publication
  2. The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions.
    Authors:
    Sabina Janciauskiene, Sabine Wrenger, Stephan Immenschuh, Beata Olejnicka, Timm Greulich, Tobias Welte and Joanna Chorostowska-Wynimko
    Academic press:
    Frontiers in Pharmacology (rok: 2018, tom: 9/Artykuł 341, strony: 45304), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fphar.2018.00341/full - link to the publication
  3. Alpha1-antitrypsin binds hemin and prevents oxidative activation of human neutrophils: putative pathophysiological significance
    Authors:
    S. Janciauskiene, S. Tumpara, M.Wiese, S. Wrenger, V. Vijayan, F. Gueler, R. Chen, K. Madyaningrana, R. Mahadeva, T. Welte, S. Immenschuh, J.Chorostowska-Wynimko
    Academic press:
    JOURNAL OF LEUKOCYTE BIOLOGY (rok: 2017, tom: 102, strony: 1127-1141), Wydawca: Wiley on behalf of the Society for Leukocyte Biology (United States)
    Status:
    Published
    DOI:
    10.1189/jlb.3A0317-124R - link to the publication
  4. Post-Translational Modifications of Circulating Alpha-1-Antitrypsin Protein
    Authors:
    Urszula Lechowicz, Stefan Rudzinski, Aleksandra Jezela-Stanek, Sabina Janciauskiene, Joanna Chorostowska-Wynimko
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 2, strony: 45309), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21239187 - link to the publication
  5. The Delivery of α1-Antitrypsin Therapy Through Transepidermal Route: Worthwhile to Explore.
    Authors:
    Srinu Tumpara, Beatriz Martinez-Delgado, Gema Gomez-Mariano, Bin Liu, David S. DeLuca, Elena Korenbaum, Danny Jonigk, Frank Jugert, Florian M. Wurm, Maria J. Wurm, Tobias Welte and Sabina Janciauskiene
    Academic press:
    Frontiers in Pharmacology (rok: 2020, tom: 11, strony: artykuł 983), Wydawca: Frontiers Media S.A
    Status:
    Published
    DOI:
    10.3389/fphar.2020.00983 - link to the publication
  6. Does urinary peptide content differ between COPD patients with and without inherited alpha-1 antitrypsin deficiency?
    Authors:
    A.Carleo, J. Chorostowska-Wynimko,T. Koeck, H.Mischak, M. Czajkowska-Malinowska, A.Rozy, T. Welte, S. Janciauskiene
    Academic press:
    International Journal of COPD (rok: 2017, tom: nie dotyczy, strony: 829–837), Wydawca: Dove Press
    Status:
    Published
    DOI:
    10.2147/COPD.S125240 - link to the publication
  7. The Beneficial Effects of Antioxidants in Health And Diseases.
    Authors:
    S.Janciauskiene
    Academic press:
    Chronic obstructive pulmonary diseases (rok: 2020, tom: 7(3), strony: 182-202), Wydawca: COPD Foundation
    Status:
    Published
    DOI:
    10.15326/jcopdf.7.3.2019.0152 - link to the publication

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