Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Searching of new compounds with anti-inflammatory activity from Oleaceae family plants growing in Poland conducted using in vitro and in vivo models followed by molecular mechanism determination

2015/17/B/NZ7/03086

Keywords:

Oleaceae forsythia lilac ash irydoids phenylethanoids lignans coumarins HPLC-MS/MS analysis bio-guided fractionation anti-inflammatory activity resolution of inflammation neutrophils macrophages monocytes lymphocytes oxidative burst cytokines proteases apoptosis phagocytosis signaling pathways transcription factor NF-κB

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Kiss 

Number of co-investigators in the project: 10

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 866 000 PLN

Project start date (Y-m-d): 2016-02-03

Project end date (Y-m-d): 2019-08-02

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Blok grzewczy do odparowania próbek (30 000 PLN)
  2. Chromatograf cieczowy preparatywny (z detektorem UV-Vis, autosamplered, oprogramowaniem) (200 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Lignans from Forsythia x intermedia leaves and flowers attenuate the pro-inflammatory function of leukocytes and their interaction with endothelial cells.
    Authors:
    Barbara Michalak, Agnieszka Filipek, Piotr Chomicki, Małgorzata Pyza, Marta Wożniak, Barbara Żyżyńska‐Granica, Jakub P. Piwowarski, Agnieszka Kicel, Monika A. Olszewska, Anna K. Kiss
    Academic press:
    Frontiers in Pharmacology (rok: 2018, tom: 9, strony: 401 (1-17)), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fphar.2018.00401 - link to the publication
  2. Hydroxycinnamoyl derivatives and secoiridoid glycoside derivatives from Syringa vulgaris flowers and their effects on the pro-inflammatory responses of human neutrophils
    Authors:
    M.K. Dudek, B. Michalak, M. Woźniak, M.E. Czerwińska, A. Filipek, S. Granica, A.K. Kiss
    Academic press:
    Fitoterapia (rok: 2017, tom: 121, strony: 194-205), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fitote.2017.07.008 - link to the publication
  3. UHPLC‐DAD‐ESI‐MS/MS and HPTLC profiling of ash leaf samples from different commercial and natural sources and their in vitro effects on mediators of inflammation
    Authors:
    Anna K. Kiss, Barbara Michalak, Andrzej Patyra,Magdalena Majdan
    Academic press:
    Phytochemical Analysis (rok: 2020, tom: 31, strony: 57-67), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/pca.2866 - link to the publication
  4. Effects of Phytochemically Characterized Extracts from Syringa vulgaris and Isolated Secoiridoids on Mediators of Inflammation in a Human Neutrophil Model
    Authors:
    Marta Woźniak, Barbara Michalak, Joanna Wyszomierska, Marta K. Dudek, Anna K. Kiss
    Academic press:
    Frontiers in Pharmacology (rok: 2018, tom: 9, strony: 349 (1-15)), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fphar.2018.00349. - link to the publication
  5. Syringa vulgaris bark as a source of compounds affecting the release of mediators of inflammation from human neutrophils and monocytes/macrophages.
    Authors:
    Agnieszka Filipek, Joanna Wyszomierska, Barbara Michalak, Anna K. Kiss
    Academic press:
    Phytochemistry Letters (rok: 2019, tom: 30, strony: 309-313), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.phytol.2019.02.008 - link to the publication

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