Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Aromatic aminotransferases from Candida albicans as molecular targets for antifungal chemotherapy.

2015/17/B/NZ6/04248

Keywords:

Candida albicans virulence factors auxotrophy

Descriptors:

  • NZ6_7: Mycology
  • NZ1_10: Microbiology
  • NZ1_9: Biotechnology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Politechnika Gdańska, Wydział Chemiczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Iwona Gabriel 

Number of co-investigators in the project: 2

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 640 000 PLN

Project start date (Y-m-d): 2016-02-15

Project end date (Y-m-d): 2019-02-14

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. System do archiwizacji wraz z oprogramowaniem i komputerem. (40 000 PLN)
  2. Czytnik wielodetekcyjny (200 000 PLN)
  3. Komputer wraz z oprogramowaniem.

Information in the final report

  • Publication in academic press/journals (3)
  1. Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties.
    Authors:
    Kiliszek A, Rypniewski W, Rząd K, Milewski S, Gabriel I.
    Academic press:
    Journal of Structural Biology (rok: 2019, tom: 205 (3), strony: 26-33), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jsb.2019.02.001 - link to the publication
  2. Consequences of lysine auxotrophy for Candida albicans adherence and biofilm formation.
    Authors:
    Gabriel I, Rychłowski M
    Academic press:
    Acta Biochim Pol. (rok: 2017, tom: 64, strony: 323-329), Wydawca: The Journal of the Polish Biochemical Society and of the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2016_1427 - link to the publication
  3. Versatility of putative aromatic aminotransferases from Candida albicans
    Authors:
    Kamila Rząd, Sławomir Milewski, Iwona Gabriel
    Academic press:
    Fungal Genetics and Biology (rok: 2018, tom: 110, strony: 26-37), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fgb.2017.11.009 - link to the publication

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