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Analysis of the regulatory sequences in the SPAST gene and the influence of these sequences changes to transcriptional and post-transciptional regulation of the SPAST gene as a pathomechanism of hereditary spastic paraplegia type 4.

2014/15/N/NZ2/00395

Keywords:

SPAST spastin hereditary spastic paraplegia HSP transcriptional regulation transcriptional factors microRNA miRNA

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ2_11: Genetic epidemiology
  • NZ2_12: Other related subjects

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Psychiatrii i Neurologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ewelina Elert-Dobkowska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 8 - announced on 2014-09-15

Amount awarded: 99 840 PLN

Project start date (Y-m-d): 2015-08-05

Project end date (Y-m-d): 2018-08-04

Project duration:: 24 months (the same as in the proposal)

Project status: Project completed