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Carbon monoxide (CO) as a physiological gastroprotective factor and modulator of hydrogen sulfide (H2S) sythesis pathways in experimental gastric mucosal damage induced by aspirin.

2014/15/N/NZ4/04564

Keywords:

carbon monoxide hydrogen sulfide cystathionine gamma-lyase cystathionine beta-synthase 3-mercaptopyruvate sulfurtransferase aspirin-induced gastric ulcers

Descriptors:

  • NZ4_2: Physiology
  • NZ1_2: Biochemistry

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marcin Magierowski 

Number of co-investigators in the project: 2

Call: PRELUDIUM 8 - announced on 2014-09-15

Amount awarded: 66 660 PLN

Project start date (Y-m-d): 2015-07-13

Project end date (Y-m-d): 2017-05-12

Project duration:: 22 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (3)
  1. Nitric oxide, afferent sensory nerves, and antioxidative enzymes in the mechanism of protection mediated by tricarbonyldichlororuthenium(II) dimer and sodium hydrosulfide against aspirin-induced gastric damage.
    Authors:
    Magierowski M, Hubalewska-Mazgaj M, Magierowska K, Wojcik D, Sliwowski Z, Kwiecien S, Brzozowski T
    Academic press:
    Journal of Gastroenterology (rok: 2017, tom: 2017, strony: 45303), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00535-017-1323-4 - link to the publication
  2. Interaction between endogenous carbon monoxide and hydrogen sulfide in the mechanism of gastroprotection against acute aspirin-induced gastric damage.
    Authors:
    Magierowski M, Magierowska K, Hubalewska-Mazgaj M, Adamski J, Bakalarz D, Sliwowski Z, Pajdo R, Kwiecien S, Brzozowski T
    Academic press:
    Pharmacological Research (rok: 2016, tom: 114, strony: 235-250), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.phrs.2016.11.001 - link to the publication
  1. EVIDENCE FOR ANTIOXIDATIVE AND ANTIINFLAMMATORY PROPERTIES OF CARBON MONOXIDE AND HYDROGEN SULFIDE IN PATHOPHYSIOLOGY OF ASPIRIN-INDUCED GASTRIC DAMAGE
    Authors:
    Magierowski M, Magierowska K, Hubalewska-Mazgaj M, Adamski J, Sliwowski Z, Wojcik D, Kwiecien S, Brzozowski T
    Conference:
    United European Gastroenterology Week 2016 (rok: 2016, ), Wydawca: United European Gastroenterology Journal; ISSN 2050-6406 (Print); ISSN 2050-6414 (Online)
    Data:
    konferencja 15-19 październik 2016
    Status:
    Published
    DOI:
    link to the publication
  2. Gaseous mediators as a protective molecules against acute gastric damage (in "9th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection"
    Authors:
    Magierowska K, Magierowski M, Kwiecien S, Adamski J, Hubalewska-Mazgaj M, Sliwowski Z, Brzozowski T
    Conference:
    9th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection (ISTICO) (rok: 2016, ), Wydawca: Symposion
    Data:
    konferencja 15-17 wrzesień 2016
    Status:
    Published
    DOI:
    link to the publication
  3. Gastroprotective effect of hydrogen sulfide and carbon monoxide against aspirin-induced damage: involvement of heme oxygenase-1 and transcription factor Nrf-2
    Authors:
    Magierowska K, Magierowski M, Kwiecien S, Adamski J, Hubalewska-Mazgaj M, Sliwowski Z, Brzozowski T
    Conference:
    4th International Conference on the Biology of Hydrogen Sulfide, Naples, Italy (rok: 2016, ), Wydawca: DIPARTIMENTO DI FARMACIA UNIVERSITA' DI NAPOLI FEDERICO II
    Data:
    konferencja 3-5 czerwiec 2016
    Status:
    Published
    DOI:
    link to the publication

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