Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Chromosome topolgy as a global regulator of gene transcription - interplay between topoisomerases and nucleoid binding proteins in bacteria adaptation to stres conditions

2014/15/B/NZ2/01067

Keywords:

topology transcription bacterial chromosome Streptomyces topoisomerases nucleoid associated proteins SMC

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ2_9: Systems biology
  • NZ2_1: Molecular genetics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Dagmara Jakimowicz 

Number of co-investigators in the project: 5

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 980 000 PLN

Project start date (Y-m-d): 2015-07-22

Project end date (Y-m-d): 2019-06-21

Project duration:: 47 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. komputery (3 szt.) (12 000 PLN)
  2. komputer.
  3. zamrażarka -80 z wyposażeniem (58 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. A highly processive actinobacterial topoisomerase I – thoughts on Streptomyces demand for enzyme with unique C-terminal domain
    Authors:
    Marcin Jan Szafran; Agnieszka Strzałka; Dagmara Jakimowicz
    Academic press:
    Microbiology SGM (rok: 2020, tom: 166(2), strony: 120-128), Wydawca: Microbiology Society
    Status:
    Published
    DOI:
    10.1099/mic.0.000841 - link to the publication
  2. C-terminal lysine repeats in Streptomyces topoisomerase I stabilize the enzyme-DNA complex and confer high enzyme processivity
    Authors:
    Agnieszka Strzalka, Marcin Jan Szafran, Terence Strick, Dagmara Jakimowicz
    Academic press:
    Nucleic Acids Res. (rok: 2017, tom: 45, strony: 11908-11924), Wydawca: OXFORD UNIV PRESS
    Status:
    Published
    DOI:
    10.1093/nar/gkx827 - link to the publication
  3. Transcriptional Response of Streptomyces coelicolor to Rapid Chromosome Relaxation or Long-Term Supercoiling Imbalance
    Authors:
    Marcin Jan Szafran, Martyna Gongerowska, Tomasz Małecki, Marie Elliot, Dagmara Jakimowicz
    Academic press:
    Frontiers in Microbiology (rok: 2019, tom: 10, strony: article 1605), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2019.01605 - link to the publication
  4. The Coordinated Positive Regulation of Topoisomerase Genes Maintains Topological Homeostasis in Streptomyces coelicolor
    Authors:
    Marcin Jan Szafran, Martyna Gongerowska, Paweł Gutkowski, Jolanta Zakrzewska-Czerwińska, Dagmara Jakimowicz
    Academic press:
    Journal of Bacteriology (rok: 2016, tom: 198, strony: 3016 –3028), Wydawca: American Society of Microbiology
    Status:
    Published
    DOI:
    10.1128/JB.00530-16 - link to the publication

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