Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Involvement of cholesterol oxidase of Mycobacterium tuberculosis in the modulation of TLR2-dependent signaling pathway in human macrophages and neutrophils.

2014/15/B/NZ6/01565

Keywords:

Mycobacterium tuberculosis macrophages cholesterol oxidase TLR2

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ6_4: Bacteriology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Biologii Medycznej PAN

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Magdalena Klink 

Number of co-investigators in the project: 5

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 685 435 PLN

Project start date (Y-m-d): 2015-09-01

Project end date (Y-m-d): 2019-08-31

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Termocykler gradientowy PCR na 96 probówek 0,2 ml, zakres temperatur 4-100 C (17 000 PLN)
  2. Zestaw do pomiaru pH w róznym zakresie temperatur.
  3. Zbiornik do przechowywania preparatów w ciekłym azocie z wyposażeniem (25 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. IRAK1 and IRAK4 signaling proteins are dispensable in the response of human neutrophils to Mycobacterium tuberculosis infection
    Authors:
    Michal Kilebik, Izabela Szulc-Kielbik, Magdalena Klink
    Academic press:
    FEMS Microbiology Letters (rok: 2019, tom: 366, strony: fnz226), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/femsle/fnz226 - link to the publication
  2. Determination of the in vitro and in vivo immune response to recombinant cholesterol oxidase from Mycobacterium tuberculosis
    Authors:
    Izabela Szulc-Kielbik, Anna Brzostek, Justyna Gatkowska, Michal Kielbik, Magdalena Klink
    Academic press:
    Immunology Letters (rok: 2020, tom: 228, strony: 103-111), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.imlet.2020.11.002 - link to the publication
  3. Mycobacterium tuberculosis requires cholesterol oxidase to disrupt TLR2 signalling in human macrophages.
    Authors:
    Izabela Szulc-Kielbik, Michal Kielbik, Patrycja Przygodzka, Anna Brzostek, Jaroslaw Dziadek, Magdalena Klink
    Academic press:
    Mediators of Inflammation (rok: 2019, tom: 2019, strony: ID 2373791, 17 pages), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2019/2373791 - link to the publication

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