Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Biophysical mechanism of synergy between integrins and sydecans in adhesion of bladder cells to extracellular matrix structural elements

2014/15/B/ST4/04737

Keywords:

dynamic force spectroscopy (AFM-DFS) single molecule unbinding Bell-Evans and Dutko-Szabo models kinetic profiles of single molecular complexes

Descriptors:

  • ST4_13: Solid-state chemistry, surface physicochemistry
  • ST4_2: Spectroscopic and spectrometric techniques
  • ST4_3: Molecular architecture and structure

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Instytut Fizyki Jądrowej im. Henryka Niewodniczańskiego PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Małgorzata Lekka 

Number of co-investigators in the project: 3

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 574 200 PLN

Project start date (Y-m-d): 2015-08-11

Project end date (Y-m-d): 2019-01-10

Project duration:: 41 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. komputer przenośny.
  2. optyczny mikroskop odwrócony (80 000 PLN)
  3. komputery (9 000 PLN)
  4. pojemnik na ciekły azot (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Book publications / chapters in book publications (1)
  1. Morphological and mechanical stability of bladder cancer cells in response to substrate rigidity
    Authors:
    Malgorzata Lekka, Joanna Pabijan, Barbara Orzechowska
    Academic press:
    Biochemica et Biophysica Acta - General Subjects (rok: 2019, tom: 1863, strony: 1006-1014), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbagen.2019.03.010 - link to the publication
  2. Atomic force microscopy as a tool for assessing the cellular elasticity and adhesiveness to identify cancer cells and tissues
    Authors:
    Joanna Zemła, Joanna Danilkiewicz, Barbara Orzechowska, Joanna Pabijan, Sara Seweryn, Małgorzata Lekka
    Academic press:
    Seminars in Cell & Developmental Biology (rok: 2018, tom: 73, strony: 115-124), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.semcdb.2017.06.029 - link to the publication
  3. How Complex Is the Concanavalin A−Carboxypeptidase Y Interaction?
    Authors:
    K. Herman, M. Weiss, M. Lekka, A. Ptak
    Academic press:
    ACS Chemical Biology (rok: 2019, tom: 14, strony: 1611-1618), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acschembio.9b00337 - link to the publication
  4. Unbinding Kinetics of Syndecans by Single-Molecule Force Spectroscopy
    Authors:
    K. Herman, M.Lekka, A.Ptak
    Academic press:
    Journal of Physical Chemistry Letters (rok: 2018, tom: 9, strony: 1509-1515), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpclett.7b03420 - link to the publication
  5. Probing the recognition specificity of alphaVbeta1 integrin and syndecan-4 using force spectroscopy
    Authors:
    M. Lekka, K. Herman, J. Zemla, L. Bodek, G. Pyka-Fościak, D. Gil, J. Dulinska-Litewka, A. Ptak, P.Laidler
    Academic press:
    Micron , Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Measuring Elastic Properties of Single Cancer Cells by AFM
    Authors:
    Małgorzata Lekka, Joanna Pabijan
    Book:
    Methods in Molecular Biology (rok: 2019, tom: 1886, strony: 315-324), Wydawca: Springer
    Status:
    Published
    DOI:
    link to the publication

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