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Information on the principal investigator and host institution

Information of the project and the call

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Efficacy, toxicity and immunogenicity of carriers made of bioengineered spider silk for targeted drug delivery

2014/15/B/NZ7/00903

Keywords:

targeted therapy bioengineered spider silk toxicity immunogenicity

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology
  • NZ1_9: Biotechnology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Hanna Dams-Kozłowska 

Number of co-investigators in the project: 8

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 695 130 PLN

Project start date (Y-m-d): 2015-09-04

Project end date (Y-m-d): 2020-09-03

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wysokoprecyzyjna waga analityczna (25 000 PLN)
  2. System oczyszczania wody (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (15)
  • Articles in post-conference publications (2)
  1. Silk Materials Functionalized via Genetic Engineering for Biomedical Applications
    Authors:
    Tomasz Deptuch and Hanna Dams-Kozlowska
    Academic press:
    Materials (rok: 2017, tom: 10, strony: 1417), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma10121417 - link to the publication
  2. Bioengineering the spider silk sequence to modify its affinity for drugs
    Authors:
    Kamil Kucharczyk, Marek Weiss, Katarzyna Jastrzebska, Magdalena Luczak, Arkadiusz Ptak, Maciej Kozak, Andrzej Mackiewicz, Hanna Dams-Kozlowska
    Academic press:
    International Journal of Nanomedicine (rok: 2018, tom: 13, strony: 4247-4261), Wydawca: DOVE MEDICAL PRESS LTD
    Status:
    Published
    DOI:
    10.2147/IJN.S168081 - link to the publication
  3. Blending two bioengineered spider silks to develop cancer targeting spheres
    Authors:
    Anna Florczak, Katarzyna Jastrzebska, Andrzej Mackiewicz and Hanna Dams-Kozlowska
    Academic press:
    Journal of Materials Chemistry B (rok: 2017, tom: 5, strony: 3000-3011), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c7tb00233e - link to the publication
  4. Composite spheres made of bioengineered spider silk and iron oxide nanoparticles for theranostics applications
    Authors:
    Kamil Kucharczyk, Jakub Dalibor Rybka, Michael Hilgendorff, Michal Krupinski, Mariusz Slachcinski, Andrzej Mackiewicz, Michael Giersig, Hanna Dams- Kozlowska
    Academic press:
    PlosOne (rok: 2019, tom: 14(7), strony: e0219790), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal. - link to the publication
  5. Delivery of chemotherapeutics using spheres made of bioengineered spider silks derived from MaSp1 and MaSp2 proteins.
    Authors:
    Jastrzebska K, Florczak A, Kucharczyk K, Lin Y, Wang Q, Mackiewicz A, Kaplan DL, Dams-Kozlowska H.
    Academic press:
    Nanomedicine (Lond). (rok: 2018, tom: 13, strony: 439-454), Wydawca: Future Medicine
    Status:
    Published
    DOI:
    10.2217/nnm-2017-0276 - link to the publication
  6. MS1-type bioengineered spider silk nanoparticles do not exhibit toxicity in an in vivo mouse model
    Authors:
    Tomasz Deptuch, Anna Florczak, Anna Lewandowska, Ewa Leporowska, Karolina Penderecka, Andrzej Marszalek, Andrzej Mackiewicz, Hanna Dams-Kozlowska
    Academic press:
    Nanomedicine (Lond) (rok: 2021, tom: 16, strony: 1553-1565), Wydawca: Future Medicine Ltd
    Status:
    Published
    DOI:
    10.2217/nnm-2021-0029 - link to the publication
  7. The method of purifying bioengineered spider silk determines the silk sphere properties.
    Authors:
    Jastrzebska K, Felcyn E, Kozak M, Szybowicz M, Buchwald T, Pietralik Z, Jesionowski T, Mackiewicz A, Dams-Kozlowska H.
    Academic press:
    Scientific reports (rok: 2016, tom: 6, strony: 6:28106), Wydawca: London : Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep28106 - link to the publication
  8. Functionalized Silk Spheres Selectively and Effectively Deliver a Cytotoxic Drug to Targeted Cancer Cells In Vivo.
    Authors:
    Anna Florczak, Tomasz Deptuch, Anna Lewandowska, Karolina Penderecka, Elzbieta Kramer, Andrzej Marszalek, Andrzej Mackiewicz, Hanna Dams-Kozlowska
    Academic press:
    Journal of Nanobiotechnology (rok: 2020, tom: 18, strony: 177), Wydawca: BMC Part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12951-020-00734-y - link to the publication
  9. Functionalized bioengineered spider silk spheres improve nuclease resistance and activity of oligonucleotide therapeutics providing a strategy for cancer treatment
    Authors:
    Anna Karolina Kozlowska, Anna Florczak, Maciej Smialek, Ewelina Dondajewska, Andrzej Mackiewicz, Marcin Kortylewski, Hanna Dams-Kozlowska
    Academic press:
    Acta Biomaterialia (rok: 2017, tom: 59, strony: 221-233), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.actbio.2017.07.014 - link to the publication
  10. Optimization of spider silk sphere formation processing conditions to obtain carriers with controlled characteristics.
    Authors:
    Florczak A, Jastrzebska K, Bialas W, Mackiewicz A, Dams-Kozlowska H.
    Academic press:
    Journal of Biomedical Materials Research Part A (rok: 2018, tom: 106, strony: 3211-3221), Wydawca: John Wiley & Sons
    Status:
    Published
    DOI:
    10.1002/jbm.a.36516. - link to the publication
  11. In Vivo Study of the Immune Response to the MS1-type Bioengineered Spider Silk Spheres
    Authors:
    Tomasz Deptuch, Karolina Penderecka, Hanna Dams-Kozlowska
    Academic press:
    NanoImpact (rok: 2021, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    nie - link to the publication
  12. Cellular uptake, intracellular distribution and degradation of Her2-targeting silk nanospheres.
    Authors:
    Florczak A, Mackiewicz A, Dams-Kozlowska H.
    Academic press:
    International Journal of Nanomedicine (rok: 2019, tom: 14, strony: 6855-6865), Wydawca: DOVE MEDICAL PRESS LTD
    Status:
    Published
    DOI:
    10.2147/IJN.S217854 - link to the publication
  13. Drug affinity and targeted delivery: double functionalization of silk spheres for controlled doxorubicin delivery into Her2‑positive cancer cells
    Authors:
    Kamil Kucharczyk, Anna Florczak, Tomasz Deptuch, Karolina Penderecka, Katarzyna Jastrzebska, Andrzej Mackiewicz, and Hanna Dams‑Kozlowska
    Academic press:
    Journal of Nanobiotechnology (rok: 2020, tom: 18, strony: 56), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12951-020-00609-2 - link to the publication
  14. Hyperthermia treatment of cancer cells by the application of targeted silk/iron oxide composite spheres
    Authors:
    Kamil Kucharczyk, Katarzyna Kaczmarek, Arkadiusz Jozefczak, Mariusz Slachcinski, Andrzej Mackiewicz, Hanna Dams-Kozlowska
    Academic press:
    Materials Science and Engineering: C (rok: 2021, tom: 120, strony: 120:111654), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.msec.2020.111654 - link to the publication
  15. Silk Particles as Carriers of Therapeutic Molecules for Cancer Treatment
    Authors:
    Anna Florczak , Inga Grzechowiak, Tomasz Deptuch, Kamil Kucharczyk, Alicja Kaminska, Hanna Dams-Kozlowska
    Academic press:
    Materials (rok: 2020, tom: 13, strony: 4946), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma13214946 - link to the publication
  1. Bioengineered silk spheres for targeted drug delivery in Her2-positive breast cancer model.
    Authors:
    Anna Florczak, Tomasz Deptuch, Anna Lewandowska, Konstanty Korski, Andrzej Mackiewicz, Hanna Dams-Kozłowska.
    Conference:
    8th International Conference of Contemporary Oncology "Integrated oncology: genomics, immunotherapies, and molecular targets". (rok: 2016, ), Wydawca: Termedia sp. z o.o.
    Data:
    konferencja 16-18 March 2016.
    Status:
    Published
  2. Efficacy of carriers made of biotechnologically produced bioengineered silk for targeted drug delivery – in vivo study
    Authors:
    Anna Florczak, Tomasz Deptuch, Konstanty Korski, Andrzej Mackiewicz, Hanna Dams-Kozlowska
    Conference:
    Bio2016 – Expanding beyond the limits (rok: 2016, ), Wydawca: Polish Biochemical Society
    Data:
    konferencja 13-16 Sept
    Status:
    Published

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