Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Effect of peritoneal mesothelium senescence on the functionality of intercellular junctions and the inducibility of epithelial-mesenchymal transition of malignant cells, in the context of the identification of a new mechanism of transmesothelial invasiveness of ovarian cancer

2014/15/B/NZ3/00421

Keywords:

cancer cell invasiveness cellular senescence mesothelial cells ovarian cancer peritoneal cavity

Descriptors:

  • NZ3_4: Ageing
  • NZ3_1: Cell biology
  • NZ3_14: Other related subjects

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski II

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Krzysztof Książek 

Number of co-investigators in the project: 6

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 677 320 PLN

Project start date (Y-m-d): 2015-07-24

Project end date (Y-m-d): 2018-07-23

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Autoklaw do klatek dla zwierząt (70 000 PLN)
  2. Loża z laminarnym przepływem powietrza do badań na zwierzętach (40 000 PLN)
  3. Mikroskop fluorescencyjny odwrócony.
  4. System oczyszczania wody.
  5. Sterylizator na suche gorące powietrze.

Information in the final report

  • Publication in academic press/journals (12)
  • Articles in post-conference publications (9)
  1. A unique pattern of mesothelial-mesenchymal transition induced in the normal peritoneal mesothelium by high-grade serous ovarian cancer
    Authors:
    Pakuła M, Uruski P, Niklas A., Woźniak A, Szpurek D., Tykarski A., Mikuła-Pietrasik J., Książek K
    Academic press:
    Cancers (rok: 2019, tom: 11, strony: 662), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11050662 - link to the publication
  2. Malignant ascites determine the transmesothelial invasion of ovarian cancer cells
    Authors:
    Mikuła-Pietrasik J, Uruski P, Szubert S, Szpurek D, Sajdak S., Tykarski A, Książek K
    Academic press:
    International Journal of Biochemistry and Cell Biology (rok: 2017, tom: 92, strony: 45456), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2017.09.002 - link to the publication
  3. Mitochondria-related oxidative stress contributes to ovarian cancer-promoting activity of mesothelial cells subjected to malignant ascites.
    Authors:
    Pakuła M, Mikuła-Pietrasik J, Stryczyński Ł, Uruski P, Szubert S, Moszyński R, Szpurek D, Sajdak S, Tykarski A, Książek K.
    Academic press:
    International Journal of Biochemistry and Cell Biology (rok: 2018, tom: 98, strony: 82-88), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2018.03.011 - link to the publication
  4. Procancerogenic activity of senescent cells: A case of the peritoneal mesothelium
    Authors:
    Mikuła-Pietrasik J, Stryczyński Ł, Uruski P, Tykarski A, Książek K
    Academic press:
    Ageing Research Reviews (rok: 2018, tom: 43, strony: 45300), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.arr.2018.01.002 - link to the publication
  5. Biochemical composition of malignant ascites determines high aggressiveness of undifferentiated ovarian tumors
    Authors:
    Mikuła-Pietrasik J., Uruski P., Szubert S., Moszyński R., Szpurek D., Sajdak S., Tykarski A., Książek K
    Academic press:
    Medical Oncology (rok: 2016, tom: 33, strony: 94), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12032-016-0810-4 - link to the publication
  6. Senescence-related deterioration of intercellular junctions in the peritoneal mesothelium promotes the transmesothelial invasion of ovarian cancer cells
    Authors:
    Pakuła M, Witucka A, Uruski P, Radziemski A, Moszyński R, Szpurek D, Maksin K, Woźniak A, Sajdak S, Tykarski A, Mikuła-Pietrasik J, Książek K
    Academic press:
    Scientific Reports (rok: 2019, tom: 20, strony: 7587), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-44123-4 - link to the publication
  7. Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases
    Authors:
    Mikuła-Pietrasik J, Uruski P, Sosińska P, Maksin K, Piotrowska-Kempisty H, Kucińska M, Murias M, Szubert S, Woźniak A, Szpurek D, Sajdak S, Piwocka K, Tykarski A, Książek K
    Academic press:
    Cell Death Dis (rok: 2016, tom: 7, strony: e2565), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/cddis.2016.417 - link to the publication
  8. Ovarian cancer-derived ascitic fluids induce a senescence-dependent pro-cancerogenic phenotype in normal peritoneal mesothelial cells
    Authors:
    Mikuła-Pietrasik J., Uruski P., Matuszkiewicz K., Szubert S., Moszyński R., Szpurek D., Sajdak S., Tykarski A., Książek K
    Academic press:
    Cellular Oncology (rok: 2016, tom: 39, strony: 473-481), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s13402-016-0289-1 - link to the publication
  9. Oxidative stress contributes to hepatocyte growth factor-dependent pro-senescence activity of ovarian cancer cells.
    Authors:
    Mikuła-Pietrasik J, Uruski P, Pakuła M, Maksin K, Szubert S, Woźniak A, Naumowicz E, Szpurek D, Tykarski A, Książek K
    Academic press:
    Free Radical Biology & Medicine (rok: 2017, tom: 110, strony: 270-279), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2017.06.015 - link to the publication
  10. The epithelial-mesenchymal transition initiated by malignant ascites underlies the transmesothelial invasion of ovarian cancer cells
    Authors:
    Pakuła M., Mikuła-Pietrasik J., Witucka A., Kostka-Jeziorny K., Uruski P., Moszyński R., Naumowicz E., Sajdak S., Tykarski A., Książek K.
    Academic press:
    Int J Molec Sci (rok: 2019, tom: 20, 137, strony: 45301), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20010137 - link to the publication
  11. The peritoneal "soil" for a cancerous "seed": a comprehensive review of the pathogenesis of intraperitoneal cancer metastases
    Authors:
    Mikuła-Pietrasik J, Uruski P, Tykarski A, Książek K
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2018, tom: 75, strony: 509-525), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-017-2663-1 - link to the publication
  12. The proangiogenic capabilities of malignant ascites generated by aggressive ovarian tumors
    Authors:
    Mikuła-Pietrasik J, Uruski P, Szubert S., Maksin K., Moszyński R., Szpurek D., Woźniak A, Sajdak S, Tykarski A, Książek K
    Academic press:
    BioMed Research International (rok: 2017, tom: ID 2592496, strony: 45300), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2017/2592496 - link to the publication
  1. A new mechanism of transmesothelial invasion of ovarian cancer cells involving senescence of normal peritoneal mesothelium
    Authors:
    Mikuła-Pietrasik J., Książek K.
    Conference:
    2nd Congress Bio2016 (rok: 2016, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 13-16 Sept
    Status:
    Published
  2. Ovarian Cancer-derived hepatocyte growth factor (HGF), insulin-like growth factor and transforming growth factor beta1 induce epithelial-mesenchymal transition in peritoneal mesothelium in Smad2/3-dependent mechanism, improving the progression of the cancer cells
    Authors:
    Mikuła-Pietrasik J., Pakuła M., Szubert S., Szpurek D., Książek K
    Conference:
    27th Congress of the Polish Physiological Society (rok: 2017, ), Wydawca: Wydawnictwo Uniwersytetu Jagiellońskiego
    Data:
    konferencja 21-27 września
    Status:
    Published
  3. Transmesothelial invasiveness of ovarian cancer cells is associated with their ability to induce premature senescence and EMT in normal peritoneal mesothelium
    Authors:
    Mikuła-Pietrasik J., Maksin K., Szubert S., Moszyński R., Wozniak A., Szpurek D., Sajdak S., Książek K
    Conference:
    2nd Congress Bio2016 (rok: 2016, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 13-16 Sept
    Status:
    Published
  4. Intraperitoneal invasiveness of ovarian cancer cells is facilitated by their ability to promote senescence and EMT in normal peritoneal mesothelium
    Authors:
    Mikuła-Pietrasik J., Maksin K., Szubert S., Wozniak A., Szpurek D., Książek K.
    Conference:
    International Charite-Mayo Conference (rok: 2017, ), Wydawca: Charite
    Data:
    konferencja 3-6 maja
    Status:
    Published
  5. Ovarian cancer cells induce senescence in the peritoneal mesothelium which facilitates their transmesothelial invasion
    Authors:
    Mikuła-Pietrasik J., Maksin K., Szubert S., Moszyński R., Wozniak A., Szpurek D., Sajdak S., Książek K
    Conference:
    10th European Congress of Biogerontology and 6th Meeting at the Nencki Institute (rok: 2016, ), Wydawca: Instytut Nenckiego PAN
    Data:
    konferencja Sept 23-24
    Status:
    Published
  6. Senescence of peritoneal mesothelial cells from a mechanistic and clinical perspective
    Authors:
    Mikuła-Pietrasik J., Książek K
    Conference:
    10th European Congress of Biogerontology and 6th Meeting at the Nencki Institute (rok: 2016, ), Wydawca: Instytut Nenckiego PAN
    Data:
    konferencja Sept 23-24
    Status:
    Published
  7. Transmesothelial invasion of ovarian cancer cells is stimulated by malignant ascites in a mechanism involving oxidative stress-dependent deterioration of intercellular junctions in peritoneal mesothelium
    Authors:
    Mikuła-Pietrasik J., Szubert S., Moszyński R., Szpurek D., Sajdak S., Książek K.
    Conference:
    9. International Charite-Mayo Conference (rok: 2017, ), Wydawca: Charite
    Data:
    konferencja 3-6 maja
    Status:
    Published
  8. Cancer cell-derived hepatocyte growth factor triggers senescence of peritoneal mesothelium contributing to increased transmesothelial invasion of ovarian cancer cells.
    Authors:
    Mikuła-Pietrasik J., Pakuła M., Maksin K., Szubert S., Wozniak A., Szpurek D., Książek K
    Conference:
    27th Congress of the Polish Physiological Society (rok: 2017, ), Wydawca: Wydawnictwo Uniwersytetu Jagiellońskiego
    Data:
    konferencja 21-27 września
    Status:
    Published
  9. Malignant ascites from aggressive type II ovarian tumors promote angiogenesis more efficiently than those from less aggressive type I cancers
    Authors:
    Mikuła-Pietrasik J., Szubert S., Maksin K. Moszyński R., Wozniak A., Szpurek D., Sajdak S., Książek K
    Conference:
    9. International Charite-Mayo Conference (rok: 2017, ), Wydawca: Charite
    Data:
    konferencja 3-6 maja
    Status:
    Published

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