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Information on the principal investigator and host institution

Information of the project and the call

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The role of heme oxygenase-1 in cardiomyocyte differentiation from induced pluripotent stem cells (Hox-Card)

2014/14/M/NZ1/00010

Keywords:

stem cells cardiomyocytes pluripotency heme oxygenase-1 microRNAs

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_5: Genetic engineering
  • NZ1_9: Biotechnology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Józef Dulak 

Number of co-investigators in the project: 11

Call: HARMONIA 6 - announced on 2014-06-16

Amount awarded: 1 778 400 PLN

Project start date (Y-m-d): 2015-06-08

Project end date (Y-m-d): 2019-06-07

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (5)
  1. Editing DNA Methylation in the Mammalian Genome.
    Authors:
    Liu XS, Wu H, Ji X, Stelzer Y, Wu X, Czauderna Szymon, Shu J, Dadon D, Young RA, Jaenisch R.
    Academic press:
    Cell (rok: 2016, tom: 167, strony: 233-247), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cell.2016.08.056 - link to the publication
  2. Heme oxygenase-1 affects generation and spontaneous cardiac differentiation of induced pluripotent stem cells.
    Authors:
    Stepniewski J, Pacholczak T, Skrzypczyk A, Ciesla M, Szade A, Szade K, Bidanel R, Langrzyk A, Grochowski R, Vandermeeren F, Kachamakova-Trojanowska N, Jez M, Drabik G, Nakanishi M, Jozkowicz A, Dulak J.
    Academic press:
    IUBMB Life (rok: 2018, tom: 70, strony: 129-142), Wydawca: Wiley, International Union of Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1002/iub.1711 - link to the publication
  3. Pharmacological versu genetic inhibition of heme oxygenase-1 - the comparison of metalloprphyrins, shRNA and CRISPR/Cas 9 system
    Authors:
    Olga Mucha, Paulina Podkalicka, Maria Czarnek, Anna Biela, Mateusz Mieczkowski, Neli Kachamakova-Trojanowska, Jacek Stepniewski, Alicja Józkowicz, Józef Dulak, Agnieszka Łoboda
    Academic press:
    Acta Biochimica Polonica (rok: 2017, tom: 65, strony: 287-286), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/abp.2017_2542 - link to the publication
  4. Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism
    Authors:
    Łoboda Agnieszka , Damulewicz M, Pyza E, Józkowicz Alicja , Dulak Józef
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2016, tom: 73, strony: 3221-47), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-016-2223-0 - link to the publication
  5. Variability in Cardiac miRNA-122 Level Determines Therapeutic Potential of miRNA-Regulated AAV Vectors
    Authors:
    Izabela Kraszewska, Mateusz Tomczyk, Kalina Andrysiak, Monika Biniecka, Anja Geisler, Henry Fechner, Michał Zembala, Jacek Stępniewski, Józef Dulak, Agnieszka Jaźwa-Kusior
    Academic press:
    Molecular Therapy Mehods and Clinical Development (rok: 2020, tom: 17, strony: 1190-1201), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.omtm.2020.05.006. - link to the publication

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