Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Genom-wide siRNA screenings for identification of new factors and pathways of human mitochondrial RNA degradation

2014/13/D/NZ2/01114

Keywords:

RNA degradation mitochondria double-stranded RNA high-throughput siRNA screening

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ3_1: Cell biology
  • NZ2_1: Molecular genetics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Biochemii i Biofizyki PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Roman Szczęsny 

Number of co-investigators in the project: 5

Call: SONATA 7 - announced on 2014-03-17

Amount awarded: 898 638 PLN

Project start date (Y-m-d): 2015-01-23

Project end date (Y-m-d): 2018-01-22

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (3)
  1. Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria.
    Authors:
    Pietras Z, Wojcik MA, Borowski LS, Szewczyk M, Kulinski TM, Cysewski D, Stepien PP, Dziembowski A, Szczesny RJ
    Academic press:
    Nature Communications (rok: 2018, tom: 9 (1), 2558, strony: www.nature.com/articles/s41467-018-05007-9), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41467-018-05007-9 - link to the publication
  2. Versatile approach for functional analysis of human proteins and efficient stable cell line generation using FLP-mediated recombination system
    Authors:
    Roman J. Szczesny, Katarzyna Kowalska, Kamila Klosowska-Kosicka, Aleksander Chlebowski, Ewelina P. Owczarek, Zbigniew Warkocki, Tomasz M. Kulinski, Dorota Adamska, Kamila Affek, Agata Jedroszkowiak, Anna V. Kotrys, Rafal Tomecki, Pawel S. Krawczyk, Lukasz S. Borowski, Andrzej Dziembowski
    Academic press:
    PLOS One (rok: 2018, tom: nie dotyczy, strony: https://journals.plos.org/plosone/), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0194887 - link to the publication
  3. Mitochondrial double stranded RNA triggers antiviral signalling in humans
    Authors:
    Ashish Dhir, Somdutta Dhir, Lukasz S. Borowski, Laura Jimenez, Michael Teitell, Agnès Rötig, Yanick J Crow, Gillian I. Rice, Darragh Duffy, Christelle Tamby, Takayuki Nojima, Arnold Munnich, Manuel Schiff, Claudia Ribeiro de Almeida, Jan Rehwinkel, Andrzej Dziembowski, Roman J. Szczesny, Nicholas J. Proudfoot
    Academic press:
    Nature (rok: 2018, tom: nie dotyczy, strony: https://www.nature.com/), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41586-018-0363-0 - link to the publication

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