Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Pharmacokinetics and organ distribution of treosulfan and its biologically active epoxy-transformers in rats

2014/13/D/NZ7/00278

Keywords:

hematopoietic stem cell transplantation tissues toxicity HPLC-MS/MS

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Michał Romański 

Number of co-investigators in the project: 4

Call: SONATA 7 - announced on 2014-03-17

Amount awarded: 187 500 PLN

Project start date (Y-m-d): 2015-01-28

Project end date (Y-m-d): 2018-01-27

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Homogenizator tkankowy (2 szt.) (25 000 PLN)
  2. Spektrofotometr.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (4)
  1. In Vivo Red Blood Cells/Plasma Partition Coefficient of Treosulfan and Its Active Monoepoxide in Rats
    Authors:
    M. Romański, A. Zacharzewska, A. Teżyk, F.K. Główka
    Academic press:
    European Journal of Drug Metabolism and Pharmacokinetics (rok: 2018, tom: 43, strony: 565-571), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s13318-018-0469-7 - link to the publication
  2. Treosulfan Pharmacokinetics and its Variability in Pediatric and Adult Patients Undergoing Conditioning Prior to Hematopoietic Stem Cell Transplantation: Current State of the Art, In-Depth Analysis, and Perspectives
    Authors:
    M. Romański, J. Wachowiak, F.K. Główka
    Academic press:
    Clinical Pharmacokinetics (rok: 2018, tom: 57, strony: 1255-1265), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/ - link to the publication
  3. Clinical bioanalysis of treosulfan and its epoxides: The importance of collected blood processing for valid pharmacokinetic results
    Authors:
    M. Romański, F. Główka
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2018, tom: 153, strony: 199-203), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.jpba.2018.02.049 - link to the publication
  4. Determination of prodrug treosulfan and its biologically active monoepoxide in rat plasma, liver, lungs, kidneys, muscle, and brain by HPLC-ESI-MS/MS method
    Authors:
    M. Romański, A. Kasprzyk, A. Teżyk, A. Widerowska, C. Żaba, F.K. Główka
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2017, tom: 140, strony: 122-129), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.jpba.2017.03.023 - link to the publication
  5. Disposition of treosulfan and its active monoepoxide in a bone marrow, liver, lungs, brain, and muscle: studies in a rat model with clinical relevance
    Authors:
    M. Romański, A. Kasprzyk, M. Walczak, A. Ziółkowska, F. Główka.
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2017, tom: 109, strony: 616-623), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.ejps.2017.09.011 - link to the publication
  1. HPLC-ESI-MS/MS analysis of prodrug treosulfan and its active monoepoxide in rat plasma, bone marrow, liver, lungs, brain, kidneys, and muscle
    Authors:
    M. Romański, A. Kasprzyk, A. Teżyk, C. Żaba, F. Główka.
    Conference:
    XXVIII International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2017) (rok: 2017, ), Wydawca: Scientific Committee and Local Organizing Committee of the XXVIII International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2017)
    Data:
    konferencja 2-5 lipca
    Status:
    Published
  2. Metoda HPLC-MS/MS oznaczania treosulfanu i jego monoepoksypochodnej w tkankach u szczurów
    Authors:
    Anna Kasprzyk, Michał Romański, Agnieszka Widerowska, Franciszek Główka
    Conference:
    Współczesna analityka farmaceutyczna i biomedyczna w ochronie zdrowia (rok: 2015, ), Wydawca: Komitet Terapii i Nauk o Leku PAN, Komisja Analizy Leku Polskie Towarzystwo Farmaceutyczne Uniwersytet Medyczny im. K. Marcinkowskiego w Poznaniu
    Data:
    konferencja 17-18 września
    Status:
    Published
  3. Distribution of treosulfan and its active monoepoxide into liver, lungs, femoral muscle, and brain in a rat model
    Authors:
    M. Romański, A. Kasprzyk, M. Walczak, F.K. Główka
    Conference:
    9th Polish-German Symposium on Pharmaceutical Sciences "Towards novel concepts in pharmaceutical sciences" (rok: 2017, ), Wydawca: Jagiellonian University Medical College, Polish Academy of Science, Polish Pharmaceutical Society
    Data:
    konferencja 26-27 maja
    Status:
    Published
  4. Organ distribution of treosulfan and its biologically active monoepoxy-transformer in rats
    Authors:
    Anna Kasprzyk, Michał Romański, Franciszek Główka
    Conference:
    8th Polish-German Symposium on Pharmaceutical Sciences "Retrospects, insights and prospects" (rok: 2015, ), Wydawca: Kiel University (Christian-Albrechts-Universität zu Kiel)
    Data:
    konferencja 29-30 maja
    Status:
    Published

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