Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Targeting peripheral cannabinoid receptors CB2 as a novel therapy to treat osteoarthritis

2014/13/B/NZ7/02311

Keywords:

cannabinoid receptor type 2 (CB2) osteoarthritis pain regeneration novel therapy biomarkers

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_4: Prevention in population health

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

INSTYTUT FARMAKOLOGII PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Katarzyna Starowicz-Bubak 

Number of co-investigators in the project: 7

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 1 553 250 PLN

Project start date (Y-m-d): 2015-02-02

Project end date (Y-m-d): 2020-02-01

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer przenośny do pracy naukowej.
  2. Urządzenie do analizy śladów i obiążenia łap w czasie rzeczywistym podczas ruchu (120 000 PLN)

Information in the final report

  • Publication in academic press/journals (11)
  • Articles in post-conference publications (28)
  • Book publications / chapters in book publications (1)
  1. Joint problems arising from lack of repair mechanisms: can cannabinoids help?
    Authors:
    Malek N., Starowicz K.
    Academic press:
    Br J Pharmacol (rok: 2019, tom: 176(10), strony: 1412-1420), Wydawca: Br J Pharmacol
    Status:
    Published
    DOI:
    10.1111/bph.14204 - link to the publication
  2. Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis.
    Authors:
    KOROSTYNSKI M, MALEK N, PIECHOTA M, STAROWICZ K.
    Academic press:
    Int J Genomics. (rok: 2017, tom: 2017, strony: 1746426), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2017/1746426 - link to the publication
  3. Cannabinoid-based therapy as a future for joint degeneration. Focus on the role of CB 2 receptor in the arthritis progression and pain: an updated review
    Authors:
    Bryk M, Starowicz K.
    Academic press:
    Pharmacol Rep (rok: 2021, tom: 73, strony: 681–699), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-021-00270-y - link to the publication
  4. Cell-type-specific gene expression patterns in the knee cartilage in an osteoarthritis rat model
    Authors:
    Korostynski M., Małek N., Piechota M., Starowicz K.
    Academic press:
    Functional & Integrative Genomics (rok: 2018, tom: 18, strony: 79-87), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10142-017-0576-6 - link to the publication
  5. Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo.
    Authors:
    Mugnaini C, Kostrzewa M, Bryk M, Mahmoud AM, Brizzi A, Lamponi S, Giorgi G, Ferlenghi F, Vacondio F, Maccioni P, Colombo G, Mor M, Starowicz K, Di Marzo V, Ligresti A, Corelli F.
    Academic press:
    J Med Chem (rok: 2020, tom: 63 (13), strony: 7369–7391), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.0c00595 - link to the publication
  6. Potencjał terapeutyczny układu endokanabinoidowego w leczeniu bólu ostrego i przewlekłego
    Authors:
    KOSTRZEWA M., STAROWICZ K.
    Academic press:
    Ból (rok: 2015, tom: 16(2), strony: 44-55), Wydawca: Index Copernicus Sp. z o.o.
    Status:
    Published
    DOI:
    brak - link to the publication
  7. Zioło, które leczy.
    Authors:
    MLOST J, KOSTRZEWA M, STAROWICZ K.
    Academic press:
    Wszechświat (rok: 2017, tom: t. 117, nr 1–3, strony: 45425), Wydawca: POLSKIE TOWARZYSTWO PRZYRODNIKÓW IM. KOPERNIKA
    Status:
    Published
    DOI:
    brak - link to the publication
  8. CB2 agonism controls pain and subchondral bone degeneration induced by mono-iodoacetate: Implications GPCR functional bias and tolerance development.
    Authors:
    Mlost J, Kostrzewa M, Borczyk M, Bryk M, Chwastek J, Korostyński M, Starowicz K.
    Academic press:
    Biomed Pharmacother (rok: 2021, tom: 136, strony: 111283), Wydawca: Science Direct
    Status:
    Published
    DOI:
    10.1016/j.biopha.2021.111283 - link to the publication
  9. Allodynia Lowering Induced by Cannabinoids and Endocannabinoids (ALICE)
    Authors:
    LUONGO L, STAROWICZ K, MAIONE S, DI MARZO V.
    Academic press:
    Pharmacological Research (rok: 2017, tom: 119, strony: 272-277), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.phrs.2017.02.019. - link to the publication
  10. Alterations in Anandamide Synthesis and Degradation during Osteoarthritis Progression in an Animal Model.
    Authors:
    Bryk M, Chwastek J, Kostrzewa M, Mlost J, Pędracka A, Starowicz K.
    Academic press:
    Int J Mol Sci. (rok: 2020, tom: 21(19), strony: 7381), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21197381 - link to the publication
  11. Sodium Monoiodoacetate Dose-Dependent Changes in Matrix Metalloproteinases and Inflammatory Components as Prognostic Factors for the Progression of Osteoarthritis
    Authors:
    Bryk M, Chwastek J, Mlost J, Kostrzewa M, Starowicz K.
    Academic press:
    Front Pharmacol (rok: 2021, tom: 12, strony: 643605), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphar.2021.643605 - link to the publication
  1. Characterization of chronic pain development in the animal model of osteoarthritis
    Authors:
    MALEK N., KOSTRZEWA M., STAROWICZ K.
    Conference:
    36th European Winter Conference on Brain Research & EBBS Winter Conference (rok: 2016, ), Wydawca: EWCBR
    Data:
    konferencja 5-12.03
    Status:
    Published
  2. Global analysis of local endocanna‐ binoid system expression in experimental model of knee osteoarthritis in OA pathogenesis.
    Authors:
    PAJĄK A., KOSTRZEWA M., MAŁEK N., Korostynski M., STAROWICZ K.
    Conference:
    The 25th Annual Symposium of the International Cannabinoid Research Society (ICRS) (rok: 2015, ), Wydawca: ICRS
    Data:
    konferencja 28.06-3.07
    Status:
    Published
    DOI:
    link to the publication
  3. Role of endocannabinoid system in the pathogenesis of osteoarthritic pain.
    Authors:
    MALEK N., STAROWICZ K.
    Conference:
    The 25th Annual Symposium of the International Cannabinoid Research Society (ICRS) (rok: 2015, ), Wydawca: ICRS
    Data:
    konferencja 28.06-3.07
    Status:
    Published
    DOI:
    link to the publication
  4. Cannabinoid Receptor Type 2 Modulation to Improve Outcomes for Cartilage Repair in the Osteoarthritic Joint.
    Authors:
    MLOST J., KAC P., BRYK M., STAROWICZ K.
    Conference:
    EFMC-ACSMEDI MedChem Frontiers (rok: 2019, ), Wydawca: EFMC-ACSMEDI MedChem Frontiers
    Data:
    konferencja 10-13.06.
    Status:
    Published
  5. Characterization of molecular changes in ascending pain pathways in the animal model of osteoarthritis
    Authors:
    MALEK N, KOSTRZEWA M, KOROSTYNSKI M, STAROWICZ K.
    Conference:
    16th World Congress on Pain (IASP) (rok: 2016, ), Wydawca: IASP
    Data:
    konferencja 26-30.09
    Status:
    Published
  6. Local administration of CB2 agonists for prevention and treatment of osteoarthritis (OA) – studies in MIA model of OA"
    Authors:
    MALEK N., KOSTRZEWA M., PAJAK A., Borowczyk J., Drukala J., STAROWICZ K.
    Conference:
    26th Annual Symposium of the International Cannabinoid Research Society (ICRS2016) (rok: 2016, ), Wydawca: ICRS
    Data:
    konferencja 26.06.-1.07.
    Status:
    Published
  7. New approaches to treating osteoarthritis implications for the endocannabinoid system in osteoblast metabolism.
    Authors:
    KOSTRZEWA M, MALEK N, PAJAK A, Borowczyk J, Madeja Z, Drukala J, Binkowski M, Czaja M, Staron J, STAROWICZ K
    Conference:
    26th Annual Symposium of the International Cannabinoid Research Society (ICRS 2016) (rok: 2016, ), Wydawca: ICRS
    Data:
    konferencja 26.06.-1.07.
    Status:
    Published
  8. The role of dorsal root ganglia neurons innervating the rat knee joints during osteoarthritis development: implications for the endocannabinoid system.
    Authors:
    PAJAK A, Dudek K, STAROWICZ K.
    Conference:
    26th Annual Symposium of the International Cannabinoid Research Society (ICRS 2016) (rok: 2016, ), Wydawca: ICRS
    Data:
    konferencja 26.06.-1.07.
    Status:
    Published
  9. ANALGESIC EFFECT OF (E)-Β-CARYOPHYLLENE IN RAT MODEL OF OSTEOARTHRITIS.
    Authors:
    KAC P., BRYK M., MLOST J., STAROWICZ K.
    Conference:
    28th Annual Symposium on the Cannabinoids (rok: 2018, ), Wydawca: 2018 International Cannabinoid Research Society
    Data:
    konferencja 30.06-05.07.2018 Leiden, Holandia
    Status:
    Published
  10. CB2 receptor as emerging target to prevent and treat osteoarthritis.
    Authors:
    KOSTRZEWA M., MALEK N., PAJAK A., Borowczyk J., Madeja Z., Drukała J., STAROWICZ K.
    Conference:
    Neuronus 2016, Ibro&Irun Neuroscience Forum Kraków (rok: 2016, ), Wydawca: Neuronus
    Data:
    konferencja 22-24.04.
    Status:
    Published
  11. CB2 receptors as a target for novel‐ analgetic and regenerative – therapy of osteoarthritis.
    Authors:
    MAŁEK N., KOSTRZEWA M., KOROSTYŃSKI M., Borowczyk J., Madeja Z., Drukala J., STAROWICZ K.
    Conference:
    Translational Pain Research"From Lab to clinic", European Pain Federation Krakow Pain School (rok: 2015, ), Wydawca: Krakow Pain School
    Data:
    konferencja 5-9.07
    Status:
    Published
  12. Molecular understandings on the activation of CB1 and blockade of TRPV1 receptors: implications for novel treatment strategy in osteoarthritis
    Authors:
    MLOST J, KOSTRZEWA M, MALEK N, STAROWICZ K.
    Conference:
    26th Annual Symposium of the International Cannabinoid Research Society (ICRS 2016) (rok: 2016, ), Wydawca: ICRS
    Data:
    konferencja 26.06.-1.07.
    Status:
    Published
  13. Novel pyrazolyl-pyridine based scaffolds targating CB2 receptors in treatment osteoarthritis-related pain.
    Authors:
    BRYK M., Kostrzewa M., Ligresti A., Corelli F., STAROWICZ K.
    Conference:
    Neuronus 2018 IBRO Neuroscience Forum (rok: 2018, ), Wydawca: Neuronus
    Data:
    konferencja 20-22.04.2018
    Status:
    Published
  14. The dissection of gene patterns altered in knee cartilage in a rat model of osteoarthritis.
    Authors:
    KOROSTYNSKI M., MALEK N., PIECHOTA M., STAROWICZ K.
    Conference:
    World Congress on Osteoarthritis (rok: 2017, ), Wydawca: OARSI
    Data:
    konferencja 27-30.04.
    Status:
    Published
  15. Therapeutic benefits of targeting CB2 receptors in the MIA model of osteoarthritis.
    Authors:
    KOSTRZEWA M, MALEK N, PAJAK A, STAROWICZ K
    Conference:
    16th World Congress on Pain (IASP) (rok: 2016, ), Wydawca: IASP
    Data:
    konferencja 26-30.09
    Status:
    Published
  16. New tool to assess walking patterns in the development of OA pain: kinetic weight bearing.
    Authors:
    MALEK N., MLOST J., KOSTRZEWA M., STAROWICZ K.
    Conference:
    World Congress on Osteoarthritis, (rok: 2017, ), Wydawca: OARSI
    Data:
    konferencja 27-30.04.
    Status:
    Published
  17. Endocannabinoid system in the MIA model of OA pain‐implications for CB2 receptors' agonists.
    Authors:
    KOSTRZEWA M., MAŁEK N., PAJĄK A., STAROWICZ K.
    Conference:
    The 25th Annual Symposium of the International Cannabinoid Research Society (ICRS) (rok: 2015, ), Wydawca: ICRS
    Data:
    konferencja 28.06-3.07
    Status:
    Published
    DOI:
    link to the publication
  18. Kinetic weight bearing: a unique and innovative instrument for osteoarthritis research
    Authors:
    MALEK N., MLOST J., KOSTRZEWA M., STAROWICZ K.
    Conference:
    16th World Congress on Pain (IASP) (rok: 2016, ), Wydawca: IASP
    Data:
    konferencja 26-30.09
    Status:
    Published
  19. Molecular basis of OA to guide the identification of new therapeutic targets
    Authors:
    STAROWICZ K.
    Conference:
    2nd Central European Biomedical Congress (CEBC) "From emerging biochemical strategies to personalized medicine" (rok: 2016, ), Wydawca: CEBC
    Data:
    konferencja 15-18.06
    Status:
    Published
  20. Targeting peripheral cannabinoid receptors CB2 as a novel therapy to treat osteoarthritis.
    Authors:
    MAŁEK N., KOSTRZEWA M., KOROSTYŃSKI M., Borowczyk J., Madeja Z., Drukala J., STAROWICZ K.
    Conference:
    The 25th Annual Symposium of the International Cannabinoid Research Society (ICRS) (rok: 2015, ), Wydawca: ICRS
    Data:
    konferencja 28.06-3.07
    Status:
    Published
    DOI:
    link to the publication
  21. (E)-Β-caryophyllene, natural compound with analge¬sic properties in rat model of osteoarthritis
    Authors:
    KAC P., BRYK M., MLOST J., STAROWICZ K.
    Conference:
    8th Annual Conference Aspects of Neuroscience (rok: 2018, ), Wydawca: Faculty of biology University of Warsaw
    Data:
    konferencja 23.11-25.11.2018 Warszawa
    Status:
    Published
  22. Analgesic effects of new pyrazolyl-pyridine based scaffolds targeting CB2 receptors in osteoarthritis-related pain.
    Authors:
    BRYK M., MLOST J., Ligresti A., Corelli F., STAROWICZ K.
    Conference:
    28th Annual Symposium on the Cannabinoids (rok: 2018, ), Wydawca: 2018 International Cannabinoid Research Society
    Data:
    konferencja 30.06-05.07.2018 Leiden, Holandia
    Status:
    Published
  23. Bone and joint problems arising from lack of repair mechanisms: can cannabinoids help?
    Authors:
    STAROWICZ K.
    Conference:
    European Workshop on Cannabinoid Research (rok: 2017, ), Wydawca: BPS
    Data:
    konferencja 31.08-2.09.
    Status:
    Published
    DOI:
    link to the publication
  24. CB2 biased agonists and their therapeutic potential in osteoarthritis.
    Authors:
    MLOST J.,BRYK M., KOSTRZEWA M., STAROWICZ K.
    Conference:
    The 29th Annual ICRS Symposium on the Cannabinoids. (rok: 2019, ), Wydawca: International Cannabinoid Research Society
    Data:
    konferencja 29.06.2019-04.07.
    Status:
    Published
  25. Evaluation of anti-nociceptive potential of dual-target compound OMDM198 in the animal model of osteoarthritis.
    Authors:
    MLOST J., KOSTRZEWA M., MALEK N., STAROWICZ K.
    Conference:
    Neuronus 2016, Ibro&Irun Neuroscience Forum Kraków (rok: 2016, ), Wydawca: Neuronus
    Data:
    konferencja 22-24.04.
    Status:
    Published
  26. Molecular foundations of OMDM198, dual-target FAAH inhibitor and TRPV1 antagonist, analgesic potential: role of TRPV1 upregulation and sensitization in osteoarthritis
    Authors:
    MLOST J., MALEK N., KOSTRZEWA M., STAROWICZ K.
    Conference:
    European Workshop on Cannabinoid Research (rok: 2017, ), Wydawca: British Pharmacological Society
    Data:
    konferencja 30.08-2.09
    Status:
    Published
  27. TRPV1 and FAAH dual blocker modulates bone mass by endocannabinoid/ endovanilloid interaction.
    Authors:
    KOSTRZEWA M., Piscitelli F., Di Marzo V., STAROWICZ K.
    Conference:
    7th Annual Symposium on the Cannabinoids (rok: 2017, ), Wydawca: ICRS
    Data:
    konferencja 22-27.06.
    Status:
    Published
    DOI:
    link to the publication
  28. Targeting endocannabinoid system with dual target FAAH inhibitor and TRPV1 antagonist in osteoarthritis treatment: novel insight into molecular mechanism of TRPV1 upregulation and sensitization.
    Authors:
    MLOST J., Malek N., Kostrzewa M., STAROWICZ K.
    Conference:
    Neuronus 2018 IBRO Neuroscience Forum (rok: 2018, ), Wydawca: Neuronus
    Data:
    konferencja 20-22.04.2018
    Status:
    Published
  1. Cannabinoids and Pain: Sites and Mechanisms of Action.
    Authors:
    STAROWICZ K, FINN D.
    Book:
    Adv Pharmacol. (rok: 2017, tom: 80, strony: 437-475), Wydawca: Elsevier
    Status:
    Published

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