Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Dysregulation of miRNA molecules responsible for maturation of oligodendrocyte precursor cells/progenitors (OPCs) as a key element of impaired remyelination in multiple sclerosis

2014/13/B/NZ6/00235

Keywords:

multiple sclerosis oligodendrocyte precursor cell/progenitor miRNA

Descriptors:

  • NZ3_6: Cell neurobiology
  • NZ5_3: Pathogenesis of human diseases
  • NZ6_1: Adaptive and innate immunity

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Przemysław Lewkowicz 

Number of co-investigators in the project: 7

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 907 900 PLN

Project start date (Y-m-d): 2015-01-23

Project end date (Y-m-d): 2019-01-22

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komora laminarna (44 000 PLN)
  2. zestaw do ilościowego oznaczania transkryptu (digital PCR) QX200, współfinansowanie.
  3. Biurowe urządzenie wielofuncyjne Kyocera M2540.
  4. Doposażenie mikroskopu contrastowo-fazowego Zeiss Axiovert 200 w moduł do analizy konfokalnej i obserwacji hodowli w czasie rzeczywistym (100 000 PLN)
  5. Komputer osobisty typu notebook (6 000 PLN)
  6. drukarka Kyocera P2040.

Information in the final report

  • Publication in academic press/journals (3)
  1. Dysregulated RNA-Induced Silencing Complex (RISC) Assembly within CNS Corresponds with Abnormal miRNA Expression during Autoimmune Demyelination
    Authors:
    Lewkowicz P, Cwiklińska H, Mycko MP, Cichalewska M, Domowicz M, Lewkowicz N, Jurewicz A, Selmaj KW
    Academic press:
    Journal Neuroscience (rok: 2015, tom: 13; 35, strony: 7521-37), Wydawca: Stanford University's HighWire Press®
    Status:
    Published
    DOI:
    10.1523/JNEUROSCI.4794-14.2015 - link to the publication
  2. MS CD49d+CD154+ Lymphocytes Reprogram Oligodendrocytes into Immune Reactive Cells Affecting CNS Regeneration
    Authors:
    Piatek P, Namiecinska M, Domowicz M, Przygodzka P, Wieczorek M, Michlewska S, Lewkowicz N, Tarkowski M and Lewkowicz P
    Academic press:
    Cells (rok: 2019, tom: 25, strony: 1508), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8121508 - link to the publication
  3. Multiple Sclerosis CD49d+CD154+ As Myelin-Specific Lymphocytes Induced During Remyelination
    Authors:
    Paweł Piatek , Magdalena Namiecinska, Małgorzata Domowicz, Marek Wieczorek, Sylwia Michlewska, Mariola Matysiak, Natalia Lewkowicz, Maciej Tarkowski and Przemysław Lewkowicz
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 15), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9010015 - link to the publication

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